Whipple Disease Differential Diagnoses

Updated: Dec 30, 2017
  • Author: Ingram M Roberts, MD, MBA; Chief Editor: Burt Cagir, MD, FACS  more...
  • Print

Diagnostic Considerations

Maintain a high clinical suspicion for Whipple disease in patients diagnosed with chronic inflammatory rheumatism that is partially or not controlled by treatment with anti-tumor necrosis factor-alpha (anti-TNF-a) agents, and whose condition worsens after such therapy. [27]

The following conditions should also be considered in the differential diagnosis of patients with suspected Whipple disease:

  • Acquired immunodeficiency (AIDS)–related complex
  • Endocarditis, bacterial and nonbacterial
  • Human immunodeficiency virus (HIV) enteropathy
  • Macroglobulinemia
  • Mycobacterium avium intracellulare infection
  • Abetalipoproteinemia and hypobetalipoproteinemia

Differential Diagnoses