Wilson Disease Differential Diagnoses

Updated: Feb 14, 2019
  • Author: Richard K Gilroy, MBBS, FRACP; Chief Editor: Praveen K Roy, MD, AGAF  more...
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DDx

Diagnostic Considerations

Clinicians must maintain a high index of suspicion for Wilson disease, particularly in the presence of only mild elevation of transaminases, or isolated neuropsychiatric involvement. [2]

Conditions to consider in the differential diagnosis of Wilson disease might include the following:

  • Autoimmune chronic active hepatitis

  • Aceruloplasminemia

  • Glycogen-storage disease type 0

  • Glycogen-storage disease type I

  • Glycogen-storage disease type II

  • Glycogen-storage disease type III

  • Glycogen-storage disease type IV

  • Glycogen-storage disease type V

  • Glycogen-storage disease type VI

  • Glycogen-storage disease type VII

  • Hepatocellular adenoma

  • Cirrhosis

  • Multiple sclerosis

  • Huntington disease

  • Depression

  • Antisocial personality disorder

  • Parkinson disease

  • Leukodystrophy

  • CNS vasculitis

  • Leigh disease

  • Neurodegenerative disease

  • α1-antitrypsin deficiency

  • Chronic anemia

  • Hereditary hemochromatosis

Differential Diagnoses