Zollinger-Ellison Syndrome Medication

Updated: Aug 05, 2015
  • Author: Praveen K Roy, MD, AGAF; Chief Editor: Philip O Katz, MD, FACP, FACG  more...
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Medication

Medication Summary

Medical therapy is aimed at control of gastric acid hypersecretion. Proton-pump inhibitors (PPIs) have been the medications of choice in managing patients with Zollinger-Ellison syndrome (ZES).

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Proton pump inhibitors

Class Summary

Drugs of choice in ZES. Inhibit gastric acid secretion by inhibition of the H+/K+/ATP-ase enzyme system in the gastric parietal cells.

Omeprazole (Prilosec)

Decreases gastric acid secretion by inhibiting parietal cell H+/K+ ATP pump. Aim of therapy is to maintain BAO < 10 mmol 1 h prior to next dose.

Lansoprazole (Prevacid)

Decreases gastric acid secretion by inhibiting parietal cell H+/K+ ATP pump. Aim of therapy is to maintain BAO < 10 mmol 1 h prior to next dose.

Pantoprazole (Protonix)

Decreases gastric acid secretion by inhibiting parietal cell H+/K+ ATP pump. Aim of therapy is to maintain BAO < 10 mmol 1 h prior to next dose.

Esomeprazole magnesium (Nexium)

S-isomer of omeprazole used for symptomatic GERD. Inhibits gastric acid secretion by inhibiting H+/K+ ATP pump at secretory surface of gastric parietal cells.

Rabeprazole sodium (Aciphex)

Decreases gastric acid secretion by inhibiting the parietal cell H+/K+ ATP pump. For short-term (4-8 wk) treatment and relief of symptomatic erosive or ulcerative GERD. In patients not healed after 8 wk, consider an additional 8-wk course.

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