Fractional Flow Reserve (FFR) Measurement Medication

Updated: Dec 30, 2019
  • Author: Eiman Jahangir, MD, FACC; Chief Editor: Karlheinz Peter, MD, PhD  more...
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Medication Summary

The goal of pharmacotherapy is to measure the fractional flow reserve (FFR) to decide whether a coronary intervention would be beneficial.


Diagnostic agents

Class Summary

A hyperemic agent such as adenosine may be used to evaluate FFR.

Adenosine (Adenocard, Adenoscan)

Adenosine slows conduction time through the AV node. It can interrupt atrioventricular reentrant tachycardia (AVRT) by blocking conduction in the AV node to restore normal sinus rhythm in paroxysmal supraventricular tachycardia (PSVT), including PSVT associated with Wolff-Parkinson-White (WPW) syndrome. It should not be given to patients with preexcitation unless by a cardiac electrophysiologist.

Locate the pressure sensor adjacent to the tip of the guide catheter, and perform a normalization procedure with the instrument. Advance the sensor to the desired measurement location, and perform measurements with the instrument. If the FFR is greater than 0.75 at baseline, proceed with administering a hyperemic stimulus (eg, intracoronary adenosine in a dose of 15-40 µg or IV adenosine at 140 µg/kg/min), and monitor measurements.

Finally, withdraw the pressure sensor and verify that pressures are equal.