Fractional Flow Reserve (FFR) Measurement Questions & Answers

1. Pijls NH, De Bruyne B, Peels K, et al. Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses. N Engl J Med. 1996 Jun 27. 334(26):1703-8. [Medline].

2. Lo EW, Menezes LJ, Torii R. On outflow boundary conditions for CT-based computation of FFR: examination using PET images. Med Eng Phys. 2019 Dec 19. [Medline].

3. Silber S, Albertsson P, Aviles FF, et al. Guidelines for percutaneous coronary interventions. The Task Force for Percutaneous Coronary Interventions of the European Society of Cardiology. Eur Heart J. 2005 Apr. 26(8):804-47. [Medline].

4. Bartunek J, Sys SU, Heyndrickx GR, Pijls NH, De Bruyne B. Quantitative coronary angiography in predicting functional significance of stenoses in an unselected patient cohort. J Am Coll Cardiol. 1995 Aug. 26(2):328-34. [Medline].

5. Fischer JJ, Samady H, McPherson JA, et al. Comparison between visual assessment and quantitative angiography versus fractional flow reserve for native coronary narrowings of moderate severity. Am J Cardiol. 2002 Aug 1. 90(3):210-5. [Medline].

6. Pijls NH, van Schaardenburgh P, Manoharan G, et al. Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of the DEFER Study. J Am Coll Cardiol. 2007 May 29. 49(21):2105-11. [Medline].

7. Tonino PA, De Bruyne B, Pijls NH, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med. 2009 Jan 15. 360(3):213-24. [Medline].

8. Stundl A, Shamekhi J, Bernhardt S, et al. Fractional flow reserve in patients with coronary artery disease undergoing TAVI: a prospective analysis. Clin Res Cardiol. 2019 Nov 2. [Medline].

9. Coronary physiology: overview. Volcano Corporation. Available at http://www.volcanocorp.com/products/functional-measurement.asp. Accessed: 5/28/2010.

10. St Jude Medical. Available at http://www.radi.se/kc_home.aspx?n=start&r=1. Accessed: 5/28/2010.

11. Diletti R, Van Mieghem NM, Valgimigli M, et al. Rapid exchange ultra-thin microcatheter using fibre-optic sensing technology for measurement of intracoronary fractional flow reserve. EuroIntervention. 2015 Aug. 11(4):428-32. [Medline].

12. Verdier-Watts F, Rioufol G, Mewton N, et al. Influence of arterial hypotension on fractional flow reserve measurements. EuroIntervention. 2015 Aug. 11(4):416-20. [Medline].

Eiman Jahangir, MD, FACC Cardiologist

Eiman Jahangir, MD, FACC is a member of the following medical societies: American College of Cardiology, American Heart Association

Disclosure: Nothing to disclose.

John A McPherson, MD, FACC, FACP Professor of Medicine, Sol and Marvin Rosenblum Chair in Medical Education, Vice-Chair for Education, Department of Medicine, Vanderbilt University Medical Center

John A McPherson, MD, FACC, FACP is a member of the following medical societies: Alpha Omega Alpha, American College of Cardiology, American College of Physicians, American Heart Association, Association of Program Directors in Internal Medicine

Disclosure: Nothing to disclose.

Karlheinz Peter, MD, PhD Professor of Medicine, Monash University; Head of Centre of Thrombosis and Myocardial Infarction, Head of Division of Atherothrombosis and Vascular Biology, Associate Director, Baker Heart Research Institute; Interventional Cardiologist, The Alfred Hospital, Australia

Karlheinz Peter, MD, PhD is a member of the following medical societies: American Heart Association, German Cardiac Society, Cardiac Society of Australia and New Zealand

Disclosure: Nothing to disclose.

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