Gastrinoma Differential Diagnoses

Updated: Dec 03, 2021
  • Author: Jennifer Lynn Bonheur, MD; Chief Editor: BS Anand, MD  more...
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Diagnostic Considerations

Antral G-cell hyperfunction and massive small intestine resection are other diagnostic considerations.

In a retrospective study, Rosentraeger et al noted the differences in the pathologic features and biologic behavior between gastrinomas and non-syndromic duodenal gastrin-producing neuroendocrine tumors (ns-gas-NETs) from 41 patients with gastrin-producing duodenal tumors. [7] Gastrinomas exhibited the following characteristics [7] :

  • Higher Ki-67 index (1.74%) than ns-gas-NETs (0.85%)
  • Increased incidence of lymph node metastases (75%) than ns-gas-NETs (6%)
  • Showed liver metastasis, resulting in more advanced disease (75%)—staged at TNM III or higher—than ns-gas-NETs (6%)
  • More often underwent surgical resection, whereas ns-gas-NETs were removed endoscopically

Differential Diagnoses