Lactose Intolerance Differential Diagnoses

1. Vesa TH, Marteau P, Korpela R. Lactose intolerance. J Am Coll Nutr. 2000 Apr. 19(2 Suppl):165S-175S. [QxMD MEDLINE Link].

2. Newcomer AD, McGill DB, Thomas PJ, et al. Tolerance to lactose among lactase-deficient American Indians. Gastroenterology. 1978 Jan. 74(1):44-6. [QxMD MEDLINE Link].

3. Di Stefano M, Miceli E, Mazzocchi S, et al. Visceral hypersensitivity and intolerance symptoms in lactose malabsorption. Neurogastroenterol Motil. 2007 Nov. 19(11):887-95. [QxMD MEDLINE Link].

4. Micic D, Rao VL, Rubin DT. Clinical approach to lactose intolerance. JAMA. 2019 Sep 26. [QxMD MEDLINE Link].

5. Malik TF, Panuganti KK. Lactose intolerance. Stat Pearls. 2019 Jan. [QxMD MEDLINE Link]. [Full Text].

6. Zhong Y, Priebe MG, Vonk RJ, et al. The role of colonic microbiota in lactose intolerance. Dig Dis Sci. 2004 Jan. 49(1):78-83. [QxMD MEDLINE Link].

7. Ponte PR, de Medeiros PH, Havt A, et al. Clinical evaluation, biochemistry and genetic polymorphism analysis for the diagnosis of lactose intolerance in a population from northeastern Brazil. Clinics (Sao Paulo). 2016 Feb. 71(2):82-9. [QxMD MEDLINE Link]. [Full Text].

8. Delacour H, Leduc A, Loucano-Perdriat A, Plantamura J, Ceppa F. Diagnosis of genetic predisposition for lactose intolerance by high resolution melting analysis. Ann Biol Clin (Paris). 2017 Feb 1. 75(1):67-74. [QxMD MEDLINE Link].

9. Auricchio S, Rubino A, Landolt M, Semenza G, Prader A. Isolated intestinal lactase deficiency in the adult. Lancet. 1963 Aug 17. 2(7303):324-6. [QxMD MEDLINE Link].

10. Upton J, Mackay R, George P. A simple gene test for lactose intolerance/adult hypolactasia. N Z Med J. 2007 Nov 9. 120(1265):U2817. [QxMD MEDLINE Link].

11. Corgneau M, Scher J, Ritie-Pertusa L, et al. Recent advances on lactose intolerance: tolerance thresholds and currently available answers. Crit Rev Food Sci Nutr. 2017 Oct 13. 57(15):3344-56. [QxMD MEDLINE Link].

12. Xiong L, Wang Y, Gong X, Chen M. Prevalence of lactose intolerance in patients with diarrhea-predominant irritable bowel syndrome: data from a tertiary center in southern China. J Health Popul Nutr. 2017 Nov 21. 36(1):38. [QxMD MEDLINE Link]. [Full Text].

13. Harvey L, Ludwig T, Hou AQ, et al. Prevalence, cause and diagnosis of lactose intolerance in children aged 1-5 years: a systematic review of 1995-2015 literature. Asia Pac J Clin Nutr. 2018. 27(1):29-46. [QxMD MEDLINE Link]. [Full Text].

14. Kern F Jr, Struthers JE Jr. Intestinal lactase deficiency and lactose intolerance in adults. JAMA. 1966 Mar 14. 195(11):927-30. [QxMD MEDLINE Link].

15. Kudlacek S, Freudenthaler O, Weissboeck H, et al. Lactose intolerance: a risk factor for reduced bone mineral density and vertebral fractures?. J Gastroenterol. 2002. 37(12):1014-9. [QxMD MEDLINE Link].

16. Di Stefano M, Veneto G, Malservisi S, et al. Lactose malabsorption and intolerance and peak bone mass. Gastroenterology. 2002 Jun. 122(7):1793-9. [QxMD MEDLINE Link].

17. Alharbi O, El-Sohemy A. Lactose intolerance (LCT-13910C>T) genotype is associated with plasma 25-hydroxyvitamin D concentrations in caucasians: a Mendelian randomization study. J Nutr. 2017 Jun. 147(6):1063-9. [QxMD MEDLINE Link].

18. Bayless TM, Rothfeld B, Massa C, et al. Lactose and milk intolerance: clinical implications. N Engl J Med. 1975 May 29. 292(22):1156-9. [QxMD MEDLINE Link].

19. Deng Y, Misselwitz B, Dai N, Fox M. Lactose intolerance in adults: biological mechanism and dietary management. Nutrients. 2015 Sep 18. 7(9):8020-35. [QxMD MEDLINE Link]. [Full Text].

20. Mishkin S. Dairy sensitivity, lactose malabsorption, and elimination diets in inflammatory bowel disease. Am J Clin Nutr. 1997 Feb. 65(2):564-7. [QxMD MEDLINE Link].

21. Portincasa P, Bonfrate L, de Bari O, Lembo A, Ballou S. Irritable bowel syndrome and diet. Gastroenterol Rep (Oxf). 2017 Feb. 5(1):11-9. [QxMD MEDLINE Link]. [Full Text].

22. Beyerlein L, Pohl D, Delco F, et al. Correlation between symptoms developed after the oral ingestion of 50 g lactose and results of hydrogen breath testing for lactose intolerance. Aliment Pharmacol Ther. 2008 Apr. 27(8):659-65. [QxMD MEDLINE Link].

23. Hermans MM, Brummer RJ, Ruijgers AM, et al. The relationship between lactose tolerance test results and symptoms of lactose intolerance. Am J Gastroenterol. 1997 Jun. 92(6):981-4. [QxMD MEDLINE Link].

24. Arola H. Diagnosis of hypolactasia and lactose malabsorption. Scand J Gastroenterol Suppl. 1994. 202:26-35. [QxMD MEDLINE Link].

25. Carroccio A, Montalto G, Cavera G, et al. Lactose intolerance and self-reported milk intolerance: relationship with lactose maldigestion and nutrient intake. Lactase Deficiency Study Group. J Am Coll Nutr. 1998 Dec. 17(6):631-6. [QxMD MEDLINE Link].

26. Suarez FL, Savaiano DA, Levitt MD. A comparison of symptoms after the consumption of milk or lactose-hydrolyzed milk by people with self-reported severe lactose intolerance. N Engl J Med. 1995 Jul 6. 333(1):1-4. [QxMD MEDLINE Link].

27. Patel YT, Minocha A. Lactose intolerance: diagnosis and management. Compr Ther. 2000 Winter. 26(4):246-50. [QxMD MEDLINE Link].

28. Suarez FL, Savaiano DA, Levitt MD. Review article: the treatment of lactose intolerance. Aliment Pharmacol Ther. 1995 Dec. 9(6):589-97. [QxMD MEDLINE Link].

29. Sethi S, Tyagi SK, Anurag RK. Plant-based milk alternatives an emerging segment of functional beverages: a review. J Food Sci Technol. 2016 Sep. 53(9):3408-23. [QxMD MEDLINE Link]. [Full Text].

30. Paul AA, Kumar S, Kumar V, Sharma R. Milk analog: plant based alternatives to conventional milk, production, potential and health concerns. Crit Rev Food Sci Nutr. 2019 Oct 16. 1-19. [QxMD MEDLINE Link].

31. Pakdaman MN, Udani JK, Molina JP, Shahani M. The effects of the DDS-1 strain of lactobacillus on symptomatic relief for lactose intolerance - a randomized, double-blind, placebo-controlled, crossover clinical trial. Nutr J. 2016 May 20. 15(1):56. [QxMD MEDLINE Link]. [Full Text].

32. Shi LH, Balakrishnan K, Thiagarajah K, Mohd Ismail NI, Yin OS. Beneficial properties of probiotics. Trop Life Sci Res. 2016 Aug. 27(2):73-90. [QxMD MEDLINE Link]. [Full Text].

33. Vonk RJ, Priebe MG, Koetse HA, et al. Lactose intolerance: analysis of underlying factors. Eur J Clin Invest. 2003 Jan. 33(1):70-5. [QxMD MEDLINE Link].

34. Suarez FL, Savaiano D, Arbisi P, et al. Tolerance to the daily ingestion of two cups of milk by individuals claiming lactose intolerance. Am J Clin Nutr. 1997 May. 65(5):1502-6. [QxMD MEDLINE Link].

35. Jarvinen RM, Loukaskorpi M, Uusitupa MI. Tolerance of symptomatic lactose malabsorbers to lactose in milk chocolate. Eur J Clin Nutr. 2003 May. 57(5):701-5. [QxMD MEDLINE Link].

36. Beja-Pereira A, Luikart G, England PR, et al. Gene-culture coevolution between cattle milk protein genes and human lactase genes. Nat Genet. 2003 Dec. 35(4):311-3. [QxMD MEDLINE Link].

37. Born P, Sekatcheva M, Rosch T, et al. Carbohydrate malabsorption in clinical routine: a prospective observational study. Hepatogastroenterology. 2006 Sep-Oct. 53(71):673-7. [QxMD MEDLINE Link].

38. Hammer HF, Hammer J. Diarrhea caused by carbohydrate malabsorption. Gastroenterol Clin North Am. 2012 Sep. 41(3):611-27. [QxMD MEDLINE Link].

39. Lomer MC, Parkes GC, Sanderson JD. Review article: lactose intolerance in clinical practice--myths and realities. Aliment Pharmacol Ther. 2008 Jan 15. 27(2):93-103. [QxMD MEDLINE Link].

40. Mattar R, de Campos Mazo DF, Carrilho FJ. Lactose intolerance: diagnosis, genetic, and clinical factors. Clin Exp Gastroenterol. 2012. 5:113-21. [QxMD MEDLINE Link]. [Full Text].

41. Bayless TM, Brown E, Paige DM. Lactase non-persistence and lactose intolerance. Curr Gastroenterol Rep. 2017 May. 19(5):23. [QxMD MEDLINE Link].

42. Szilagyi A, Galiatsatos P, Xue X. Systematic review and meta-analysis of lactose digestion, its impact on intolerance and nutritional effects of dairy food restriction in inflammatory bowel diseases. Nutr J. 2016 Jul 13. 15(1):67. [QxMD MEDLINE Link]. [Full Text].

43. Szilagyi A. Adult lactose digestion status and effects on disease. Can J Gastroenterol Hepatol. 2015 Apr. 29(3):149-56. [QxMD MEDLINE Link]. [Full Text].

Praveen K Roy, MD, MSc Clinical Assistant Professor of Medicine, University of New Mexico School of Medicine

Praveen K Roy, MD, MSc is a member of the following medical societies: Alaska State Medical Association, American Gastroenterological Association

Disclosure: Nothing to disclose.

Sarah D Komanapalli, MBBS Resident Physician in Internal Medicine, Marshfield Clinic

Sarah D Komanapalli, MBBS is a member of the following medical societies: American College of Physicians

Disclosure: Nothing to disclose.

Homayoun Shojamanesh, MD Former Fellow, Digestive Diseases Branch, National Institutes of Health

Homayoun Shojamanesh, MD is a member of the following medical societies: American College of Gastroenterology, American Gastroenterological Association, American Society for Gastrointestinal Endoscopy

Disclosure: Nothing to disclose.

Showkat Bashir, MD Assistant Professor, Department of Medicine, Division of Gastroenterology, George Washington University, Washington, DC

Showkat Bashir, MD is a member of the following medical societies: American College of Gastroenterology, American College of Physicians, American Gastroenterological Association, American Medical Association

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

BS Anand, MD Professor, Department of Internal Medicine, Division of Gastroenterology, Baylor College of Medicine

BS Anand, MD is a member of the following medical societies: American Association for the Study of Liver Diseases, American College of Gastroenterology, American Gastroenterological Association, American Society for Gastrointestinal Endoscopy

Disclosure: Nothing to disclose.

Burt Cagir, MD, FACS Associate Regional Dean and Professor of Surgery, Geisinger Commonwealth School of Medicine; Director, General Surgery Residency Program, Executive Director, Donald Guthrie Foundation for Research and Education, Guthrie Robert Packer Hospital; Medical Director, Guthrie/RPH Skills and Simulation Lab; Associate in Surgery, Guthrie Robert Packer Hospital and Corning Hospital

Burt Cagir, MD, FACS is a member of the following medical societies: American College of Surgeons, Association of Program Directors in Surgery, Society for Surgery of the Alimentary Tract

Disclosure: Nothing to disclose.

Ronnie Fass, MD, FACP, FACG Chief of Gastroenterology, Head of Neuroenteric Clinical Research Group, Southern Arizona Veterans Affairs Health Care System; Professor of Medicine, Division of Gastroenterology, University of Arizona School of Medicine

Ronnie Fass, MD, FACP, FACG is a member of the following medical societies: American College of Gastroenterology, American College of Physicians-American Society of Internal Medicine, American Gastroenterological Association, American Neurogastroenterology and Motility Society, American Society for Gastrointestinal Endoscopy, Israeli Medical Association

Disclosure: Received grant/research funds from Takeda Pharmaceuticals for conducting research; Received consulting fee from Takeda Pharmaceuticals for consulting; Received honoraria from Takeda Pharmaceuticals for speaking and teaching; Received consulting fee from Vecta for consulting; Received consulting fee from XenoPort for consulting; Received honoraria from Eisai for speaking and teaching; Received grant/research funds from Wyeth Pharmaceuticals for conducting research; Received grant/research funds f.

Douglas M Heuman, MD, FACP, FACG, AGAF Chief of Hepatology, Hunter Holmes McGuire Department of Veterans Affairs Medical Center; Professor, Department of Internal Medicine, Division of Gastroenterology, Virginia Commonwealth University School of Medicine

Douglas M Heuman, MD, FACP, FACG, AGAF is a member of the following medical societies: American Association for the Study of Liver Diseases, American College of Physicians, American Gastroenterological Association

Disclosure: Received grant/research funds from Novartis for other; Received grant/research funds from Bayer for other; Received grant/research funds from Otsuka for none; Received grant/research funds from Bristol Myers Squibb for other; Received none from Scynexis for none; Received grant/research funds from Salix for other; Received grant/research funds from MannKind for other.

Abhishek Choudhary, MD Resident Physician, Department of Internal Medicine, University Hospital of Missouri-Columbia

Abhishek Choudhary, MD is a member of the following medical societies: American College of Physicians

Disclosure: Nothing to disclose.

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