Primary Sclerosing Cholangitis Questions & Answers

Updated: Nov 21, 2019
  • Author: Vikas Khurana, MD, FACP, FACG; Chief Editor: Vinay Kumar Kapoor, MBBS, MS, FRCS, FAMS  more...
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Questions & Answers

Overview

What is primary sclerosing cholangitis (PSC)?

What is the pathogenesis of primary sclerosing cholangitis (PSC)?

What is the prevalence of primary sclerosing cholangitis (PSC) and which patient groups are at highest risk?

What is the prognosis of primary sclerosing cholangitis (PSC)?

What is the revised Mayo Clinic model for survival probability in primary sclerosing cholangitis (PSC)?

What is the Child-Turcotte-Pugh scale for primary sclerosing cholangitis (PSC)?

How does alkaline phosphatase levels affect the prognosis of primary sclerosing cholangitis (PSC)?

What are the complications of primary sclerosing cholangitis (PSC)?

Presentation

How frequently is inflammatory bowel disease (IBD) comorbid with primary sclerosing cholangitis (PSC)?

What are the signs and symptoms of primary sclerosing cholangitis (PSC)?

Which physical findings are characteristic of primary sclerosing cholangitis (PSC)?

DDX

Which conditions should be included in the differential diagnoses of primary sclerosing cholangitis (PSC)?

What are the differential diagnoses for Primary Sclerosing Cholangitis?

Workup

Which tests are performed in the evaluation for primary sclerosing cholangitis (PSC)?

What is the role of lab studies in the workup of primary sclerosing cholangitis (PSC)?

What is the role of imaging studies in the workup of primary sclerosing cholangitis (PSC)?

Which histologic findings are characteristic of primary sclerosing cholangitis (PSC)?

What are the stages of primary sclerosing cholangitis (PSC)?

Treatment

What are the treatment options for primary sclerosing cholangitis (PSC)?

What is the role of ursodeoxycholic acid (UDCA) in the treatment of primary sclerosing cholangitis (PSC)?

What is the role of liver transplantation in the treatment of primary sclerosing cholangitis (PSC)?

What is the role of dietary and activity modifications in the treatment of primary sclerosing cholangitis (PSC)?

Which specialist consultations are beneficial in the management of primary sclerosing cholangitis (PSC)?

What is included in the long-term monitoring of patients with primary sclerosing cholangitis (PSC)?

Medications

What is the role of pharmacologic therapy for primary sclerosing cholangitis (PSC)?

Which medications in the drug class Lipid-Lowering Agents, Other are used in the treatment of Primary Sclerosing Cholangitis?

Which medications in the drug class Gallstone Solubilizing Agents are used in the treatment of Primary Sclerosing Cholangitis?

Which medications in the drug class Chelators are used in the treatment of Primary Sclerosing Cholangitis?

Which medications in the drug class Immunosuppressant agents are used in the treatment of Primary Sclerosing Cholangitis?