Phyllodes Tumor (Cystosarcoma Phyllodes) Questions & Answers

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2. Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, et al. Phyllodes tumours of the breast: a consensus review. Histopathology. 2016 Jan. 68 (1):5-21. [QxMD MEDLINE Link].

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4. Jones AM, Mitter R, Poulsom R, Gillett C, Hanby AM, Tomlinson IP, et al. mRNA expression profiling of phyllodes tumours of the breast: identification of genes important in the development of borderline and malignant phyllodes tumours. J Pathol. 2008 Dec. 216 (4):408-17. [QxMD MEDLINE Link].

5. Abe M, Miyata S, Nishimura S, Iijima K, Makita M, Akiyama F, et al. Malignant transformation of breast fibroadenoma to malignant phyllodes tumor: long-term outcome of 36 malignant phyllodes tumors. Breast Cancer. 2011 Oct. 18 (4):268-72. [QxMD MEDLINE Link].

6. Brooks HL, Priolo S, Waxman. Cystosarcoma phylloides: a case report of an 11-year survival and review of surgical experience. Contemp Surg. 1998. 53:169-72.

7. Yohe S, Yeh IT. "Missed" diagnoses of phyllodes tumor on breast biopsy: pathologic clues to its recognition. Int J Surg Pathol. 2008 Apr. 16 (2):137-42. [QxMD MEDLINE Link].

8. Pezner RD, Schultheiss TE, Paz IB. Malignant phyllodes tumor of the breast: local control rates with surgery alone. Int J Radiat Oncol Biol Phys. 2008 Jul 1. 71 (3):710-3. [QxMD MEDLINE Link].

9. Jones AM, Mitter R, Springall R, Graham T, Winter E, Gillett C, et al. A comprehensive genetic profile of phyllodes tumours of the breast detects important mutations, intra-tumoral genetic heterogeneity and new genetic changes on recurrence. J Pathol. 2008 Apr. 214 (5):533-44. [QxMD MEDLINE Link].

10. Wei J, Tan YT, Cai YC, Yuan ZY, Yang D, Wang SS, et al. Predictive factors for the local recurrence and distant metastasis of phyllodes tumors of the breast: a retrospective analysis of 192 cases at a single center. Chin J Cancer. 2014 Oct. 33 (10):492-500. [QxMD MEDLINE Link].

11. Rodrigues MF, Truong PT, McKevitt EC, Weir LM, Knowling MA, Wai ES. Phyllodes tumors of the breast: The British Columbia Cancer Agency experience. Cancer Radiother. 2018 Apr. 22 (2):112-119. [QxMD MEDLINE Link].

12. Nabi J, Akhter SM, Authoy FN. A case of large phyllodes tumor causing "rupture" of the breast: a unique presentation. Case Rep Oncol Med. 2013. 2013:871292. [QxMD MEDLINE Link]. [Full Text].

13. Jung YY, Lee YK, Koo JS. Expression of lipid metabolism-related proteins in breast phyllodes tumors. Neoplasma. 2016. 63 (2):254-62. [QxMD MEDLINE Link].

14. Bellezza G, Prosperi E, Del Sordo R, Colella R, Rulli A, Sidoni A. IMP3 Is Strongly Expressed in Malignant Phyllodes Tumors of the Breast: An Immunohistochemical Study. Int J Surg Pathol. 2016 Feb. 24 (1):37-42. [QxMD MEDLINE Link].

15. Al-Masri M, Darwazeh G, Sawalhi S, Mughrabi A, Sughayer M, Al-Shatti M. Phyllodes tumor of the breast: role of CD10 in predicting metastasis. Ann Surg Oncol. 2012 Apr. 19 (4):1181-4. [QxMD MEDLINE Link].

16. Jardim DL, Conley A, Subbiah V. Comprehensive characterization of malignant phyllodes tumor by whole genomic and proteomic analysis: biological implications for targeted therapy opportunities. Orphanet J Rare Dis. 2013 Jul 30. 8:112. [QxMD MEDLINE Link]. [Full Text].

17. Catanzariti F, Avendano D, Cicero G, Garza-Montemayor M, Sofia C, Venanzi Rullo E, et al. High-risk lesions of the breast: concurrent diagnostic tools and management recommendations. Insights Imaging. 2021 May 26. 12 (1):63. [QxMD MEDLINE Link]. [Full Text].

18. Cole-Beuglet C, Soriano R, Kurtz AB, Meyer JE, Kopans DB, Goldberg BB. Ultrasound, x-ray mammography, and histopathology of cystosarcoma phylloides. Radiology. 1983 Feb. 146 (2):481-6. [QxMD MEDLINE Link]. [Full Text].

19. Kawashima H, Miyati T, Ohno N, Ohno M, Inokuchi M, Ikeda H, et al. Differentiation between phyllodes tumours and fibroadenomas using intravoxel incoherent motion magnetic resonance imaging: comparison with conventional diffusion-weighted imaging. Br J Radiol. 2018 Apr. 91 (1084):20170687. [QxMD MEDLINE Link].

20. Niu S, Huang J, Li J, Liu X, Wang D, Wang Y, et al. Differential diagnosis between small breast phyllodes tumors and fibroadenomas using artificial intelligence and ultrasound data. Quant Imaging Med Surg. 2021 May. 11 (5):2052-2061. [QxMD MEDLINE Link]. [Full Text].

21. Yasir S, Gamez R, Jenkins S, Visscher DW, Nassar A. Significant histologic features differentiating cellular fibroadenoma from phyllodes tumor on core needle biopsy specimens. Am J Clin Pathol. 2014 Sep. 142 (3):362-9. [QxMD MEDLINE Link].

22. Efared B, Ebang GA, Tahiri L, Sidibé IS, Erregad F, Hammas N, et al. Phyllodes tumors of the breast: clinicopathological analysis of 106 cases from a single institution. Breast Dis. 2018. 37 (3):139-145. [QxMD MEDLINE Link].

23. Yom CK. Malignant Phyllodes of Breast. Adv Exp Med Biol. 2021. 1187:601-612. [QxMD MEDLINE Link].

24. Johnson HM, Mohamed A, Hassan MM, Geradts J, Geisel L, Vohra NA, et al. Race-Related Differences in the Clinical Presentation and Histopathologic Features of Phyllodes Tumor. Am Surg. 2021 Jun 30. 31348211029841. [QxMD MEDLINE Link].

25. [Guideline] Bendifallah S, Canlorbe G. [Common benign breast tumors including fibroadenoma, phyllodes tumors, and papillary lesions: Guidelines]. J Gynecol Obstet Biol Reprod (Paris). 2015 Dec. 44 (10):1017-29. [QxMD MEDLINE Link].

26. Adam MJ, Bendifallah S, Kalhorpour N, Cohen-Steiner C, Ropars L, Mahmood A, et al. Time to revise classification of phyllodes tumors of breast? Results of a French multicentric study. Eur J Surg Oncol. 2018 Nov. 44 (11):1743-1749. [QxMD MEDLINE Link].

27. Chen WH, Cheng SP, Tzen CY, Yang TL, Jeng KS, Liu CL, et al. Surgical treatment of phyllodes tumors of the breast: retrospective review of 172 cases. J Surg Oncol. 2005 Sep 1. 91 (3):185-94. [QxMD MEDLINE Link].

28. Contarini O, Urdaneta LF, Hagan W, Stephenson SE Jr. Cystosarcoma phylloides of the breast: a new therapeutic proposal. Am Surg. 1982 Apr. 48 (4):157-66. [QxMD MEDLINE Link].

29. Onkendi EO, Jimenez RE, Spears GM, Harmsen WS, Ballman KV, Hieken TJ. Surgical treatment of borderline and malignant phyllodes tumors: the effect of the extent of resection and tumor characteristics on patient outcome. Ann Surg Oncol. 2014 Oct. 21 (10):3304-9. [QxMD MEDLINE Link].

30. [Guideline] Lavoué V, Fritel X, Antoine M, Beltjens F, Bendifallah S, Boisserie-Lacroix M, et al. Clinical practice guidelines from the French College of Gynecologists and Obstetricians (CNGOF): benign breast tumors - short text. Eur J Obstet Gynecol Reprod Biol. 2016 May. 200:16-23. [QxMD MEDLINE Link].

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Donald R Lannin, MD Professor, Department of Surgery, Section of Oncology, Director Emeritus, Yale-New Haven Breast Center

Donald R Lannin, MD is a member of the following medical societies: Alpha Omega Alpha, American Cancer Society, American College of Surgeons

Disclosure: Nothing to disclose.

Anastasios K Konstantakos, MD Clinical Associate Surgeon, Department of Cardiovascular Surgery, Billings Clinic

Disclosure: Nothing to disclose.

John H Raaf, MD, PhD (Retired) Professor, Department of Surgery, Case Western Reserve University School of Medicine

John H Raaf, MD, PhD is a member of the following medical societies: American Association for Cancer Research, American College of Surgeons, Central Surgical Association, Society of Surgical Oncology, American Association of Endocrine Surgeons, American Society of Clinical Oncology

Disclosure: Nothing to disclose.

John Geibel, MD, MSc, DSc, AGAF Vice Chair and Professor, Department of Surgery, Section of Gastrointestinal Medicine, Professor, Department of Cellular and Molecular Physiology, Yale University School of Medicine; Director of Surgical Research, Department of Surgery, Yale-New Haven Hospital; American Gastroenterological Association Fellow; Fellow of the Royal Society of Medicine

John Geibel, MD, MSc, DSc, AGAF is a member of the following medical societies: American Gastroenterological Association, American Physiological Society, American Society of Nephrology, Association for Academic Surgery, International Society of Nephrology, New York Academy of Sciences, Society for Surgery of the Alimentary Tract

Disclosure: Nothing to disclose.

Brian James Daley, MD, MBA, FACS Associate Program Director, Professor, Department of Surgery, Division of Trauma and Critical Care, University of Tennessee School of Medicine

Brian James Daley, MD, MBA, FACS is a member of the following medical societies: American Association for the Surgery of Trauma, American College of Chest Physicians, American College of Surgeons, American Medical Association, Association for Academic Surgery, Association for Surgical Education, Eastern Association for the Surgery of Trauma, Shock Society, Society of Critical Care Medicine, Southeastern Surgical Congress, andTennessee Medical Association

Disclosure: Nothing to disclose.

Michael A Grosso, MD Consulting Staff, Department of Cardiothoracic Surgery, St Francis Hospital

Michael A Grosso, MD is a member of the following medical societies: American College of Surgeons, Society of Thoracic Surgeons, and Society of University Surgeons

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD, Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Reference Salary Employment

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