Gastric Outlet Obstruction Treatment & Management

Updated: Jun 11, 2018
  • Author: Andres E Castellanos, MD; Chief Editor: John Geibel, MD, DSc, MSc, AGAF  more...
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Treatment

Approach Considerations

Once the diagnosis of gastric outlet obstruction (GOO) is suspected, request a surgical consultation. GOO due to benign ulcer disease may be treated medically if results of imaging studies or endoscopy determine that acute inflammation and edema are the principal causes of the outlet obstruction (as opposed to scarring and fibrosis, which may be fixed).

If medical therapy conducted for a reasonable period fails to alleviate the obstruction, then surgical intervention becomes appropriate. Typically, if resolution or improvement is not seen within 48-72 hours, surgical intervention is necessary. The choice of surgical procedure depends upon the patient's particular circumstances; however, vagotomy and antrectomy should be considered the criterion standard against which the efficacy of other procedures is measured.

In cases of malignant obstruction, weigh the extent of surgical intervention for the relief of GOO against the malignancy's type and extent, as well as the patient's anticipated long-term prognosis. As a guiding principle, undertake major tumor resections in the absence of metastatic disease in a patient who can withstand such a procedure from a nutritional standpoint. In patients with largely metastatic disease, determine the degree of surgical intervention for palliation in light of the patient's realistic prognosis and personal wishes.

Contraindications for surgery relate to the underlying medical condition. Most patients benefit from an initial period of gastric decompression, hydration, and correction of electrolyte imbalances. In patients who are severely malnourished, postponing surgical intervention until the nutritional status has been optimized may be wise. In selective cases, some patients may benefit from total parenteral nutrition (TPN) or distal tube feeding (eg, placed via a percutaneous jejunostomy).

One of the relative contraindications for surgery is the presence of advanced malignancy; in these cases, in which life expectancy may be limited to a few months, palliation via endoscopically placed stents should be considered.

Overall, every patient with GOO deserves evaluation by a surgeon. Even if the patient has unresectable disease, palliative surgical measures may improve the quality of life.

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Medical Therapy

Initial management of GOO should be the same regardless of the primary cause. After a diagnosis is made, admit patients for hydration and correction of electrolyte abnormalities. Remembering that the metabolic alkalosis of GOO responds to the administration of chloride is important; therefore, sodium chloride solution should be the initial intravenous (IV) fluid of choice. Potassium deficits are corrected after repletion of volume status and after replacement of chloride.

Place a nasogastric (NG) tube to decompress the stomach. Occasionally, a large tube is required because the undigested food blocks tubes with small diameters.

When acute peptic ulcer disease (PUD) has been identified as a primary cause of GOO, focus treatment on the reduction of acid production. Histamine-2 (H2) blockers and proton pump inhibitors are the mainstay of treatment.

Treat H pylori infection, when identified, according to current recommendations. Although most patients improve temporarily with treatment, scarring and fibrosis may worsen over time. Pneumatic balloon dilatation of a chronic, benign stricture can be performed via endoscopy. Patients who are candidates for balloon dilatation are likely to present with recurrent GOO.

Published series using this technique report success rates of over 76% after multiple dilatations, [3]  though the rate of failure and recurrent obstruction is higher in patients treated with balloon dilatation who have not also been treated for H pylori infection. [4] Patients who are negative for H pylori do not respond favorably to balloon dilatation and should be considered for surgical treatment early in the process. [5]

Further treatment is tailored to the underlying cause; this is where the distinction between benign and malignant disease becomes important.

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Surgical Therapy

Preparation for surgery

Perform standard preoperative evaluation in these patients. Correct fluid and electrolyte abnormalities prior to surgery. Perform gastric decompression by NG tube and suction and alert the anesthesiologist to the potential risk for aspiration upon induction.

Perform a preoperative nutritional evaluation and initiate appropriate nutritional therapy (ie, TPN or enteral feedings via a percutaneous jejunostomy placed distal to the obstruction) as soon as possible. Maximizing preoperative nutrition can greatly reduce or eliminate postoperative complications related to delayed healing.

Management of benign disease

More than 75% of patients presenting with GOO eventually require surgical intervention. [6] Surgical intervention usually provides definitive treatment of GOO, but it may result in its own comorbid consequences. Operative management should offer relief of obstruction and correction of the acid problem.

The most common surgical procedures performed for GOO related to PUD are vagotomy and antrectomy, vagotomy and pyloroplasty, truncal vagotomy and gastrojejunostomy, pyloroplasty, and laparoscopic variants [7] of the aforementioned procedures. The video below demonstrates robotic-assisted pyloroplasty.

Robotic-assisted esophagectomy pyloroplasty. Courtesy of Memorial Sloan-Kettering Cancer Center, featuring Inderpal S. Sarkaria, MD.

Vagotomy and antrectomy with Billroth II reconstruction (gastrojejunostomy) seem to offer the best results. Vagotomy and pyloroplasty and pyloroplasty alone, although used with some success, can be technically difficult to perform due to scarring at the gastric outlet. A combination of balloon dilatation and highly selective vagotomy has been described, but it is associated with gastroparesis and a high recurrence rate.

Placement of a jejunostomy tube at the time of surgery should be considered. This provides temporary feeding access in already malnourished patients. Also, in chronically dilated partial obstructions, the stomach may be slow to recover a normal rate of emptying.

The role of the laparoscopic approach in the treatment of GOO is under investigation and may represent a valid form of therapy with low morbidity. The experience of several international centers has been published. One group in China performed laparoscopic truncal vagotomy and gastrojejunostomy for GOO related to PUD, with nearly complete resolution of symptomatology. The investigators reported no conversions to open procedure or mortalities. Twenty-seven percent of patients did experience transiently delayed gastric emptying, which resolved with conservative measures. [8]

Kim et al also reported good results from the use of laparoscopic truncal vagotomy with gastrojejunostomy, including shorter operating times and hospital stays in comparison with the open procedure. [9]

Hall et al performed a double-blind, multicenter, randomized, controlled trial comparing patient recovery following laparoscopic pyloromyotomy to that after open pyloromyotomy in infants with pyloric stenosis. [10] (See image below.) The investigators found that among the 87 infants who underwent the laparoscopic procedure, the median (interquartile range) postoperative time needed to achieve full enteral feeding was 18.5 hours, compared with 23.9 hours in the 93 infants who underwent open pyloromyotomy. The median postoperative length of stay in the laparoscopic and open pyloromyotomy groups were 33.6 hours and 43.8 hours, respectively.

Completed myotomy in open pyloromyotomy for hypert Completed myotomy in open pyloromyotomy for hypertropic pylotic stenosis.

The study also found that the incidence of postoperative vomiting was similar in the open and laparoscopic groups, as was the frequency of intraoperative and postoperative complications. The authors suggested that open and laparoscopic pyloromyotomy are safe means of treating infantile pyloric stenosis. Because of its apparent advantages, however, they recommended that in centers with suitable laparoscopic experience, the laparoscopic form of the procedure be used.

Management of malignant disease

The management of GOO secondary to malignancy is controversial. Of patients with periampullary cancer, 30-50% present with nausea and vomiting at the time of diagnosis. [11, 12] Most of these tumors are unresectable (approximately 40% of gastric cancers and 80-90% of periampullary cancers). [13, 14] When tumors are found to be unresectable, 13-20% of patients eventually develop GOO before they succumb to their disease. The 1-year survival rate is poor.

Gastrojejunostomy remains the surgical treatment of choice for GOO secondary to malignancy. Although surgeons traditionally have preferred an antecolic anastomosis to prevent further obstruction by advancing tumor growth, a publication evaluating the retrocolic anastomosis in this setting challenges conventional wisdom. [15] Results demonstrate that a retrocolic anastomosis may be associated with decreased incidences of delayed gastric emptying (6% vs 17%) and late GOO (2% vs 9%).

Other groups have illustrated that partial stomach-partitioning gastrojejunostomy decreases the rates of delayed gastric emptying as compared with traditional gastrojejunostomy. [16] Feeding jejunostomy should again be considered to combat malnutrition and slow recovery of gastric emptying.

Internationally, studies are under way using laparoscopic gastrojejunostomy instead of the open procedure. In the United States, critics cite a nearly 20% conversion rate and a delay in the return of gut function as reasons to not perform the procedure laparoscopically. Comparisons of laparoscopic GI anastomosis versus the open procedure have revealed less morbidity and mortality, shorter hospital stays, fewer blood transfusions, and faster GI transit recovery time. [17, 18]

Researchers at Johns Hopkins Hospital have attempted endoscopic transgastric approaches to create a gastrojejunostomy in a porcine model. [19] As natural orifice transluminal surgery gains more widespread interest, these novel approaches may become more popular.

Chopita et al reported on the use of magnetic endoscopic gastroenteric anastomosis in 15 patients with malignant gastroenteric obstruction. The procedure had an 86.7% success rate, with the authors noting the additional benefits of shorter duration of hospital stay and good quality of life in patients. [20] Although still experimental, this procedure may one day be a surgical option.

No et al reported that gastrojejunostomy was preferable to metal stent placement in providing palliation of GOO caused by unresectable or metastatic cancer in patients with a good performance status. [21]

Self-expandable metallic stents also have been used for the treatment of GOO in a malignant setting. [22, 23] Metallic stents have previously been used successfully to treat stenosis of such areas as the blood vessels, bile duct, esophagus, and trachea. With the development of newer stents and delivery systems, metallic stents may have a role in the nonsurgical treatment of gastroduodenal obstruction. Stents may allow the physician to avoid complicated surgical procedures.

Currently, only the Wallstent has FDA approval for palliation in malignant gastroduodenal obstruction. Significant complications include the following: malposition, misdeployment, tumor ingrowth or overgrowth, migration, bleeding, and perforation. [24]

A review of 19 studies published in 2004 quoted clinical success rates of 80-90%. [25] Subsequent multicenter trials using the enteral Wallstent in 176 patients with malignant GOO resulted in 89% of patients tolerating oral intake for a median of 219 days postprocedure. Of the 84% in whom the stent was successful after the initial procedure, 22% required restenting to tolerate an oral diet. In addition, as other studies have demonstrated, chemotherapy was independently associated with an increased tolerance in oral intake. [26]

One proposed solution uses covered metallic stents that have a lower incidence of tumor ingrowth. A 60% rate of tumor ingrowth in uncovered stents versus a 10% rate of tumor ingrowth in covered stents has been reported. Furthermore, with the double stent technique, that is, simultaneous placement of both covered stents and uncovered stents, lower early restenosis rates have been achieved. A stent patency of 21.5 days for uncovered stents versus 150 days for double stents has been achieved. [27]

Of the 62 patients studied by Maetani et al, half received uncovered stents and half covered stents. The authors found no statistical differency in patency, but the triple-covered stent resulted in less frequent dysfunction four weeks after stenting. [28]

Several retrospective studies have been performed to compare the results of stenting withm those of surgical intervention. Survival rates are equivalent; however, costs, length of stay, and number of subsequent procedures are all decreased following stenting. [29, 30] In addition, a delay of gastric emptying and morbidity decrease with the use of metallic stents. [31] These promising results suggest that stents may eventually replace surgery as palliative intervention for unresectable periampullary malignancies.

A 2011 study from the Netherlands discusses the use of a D-Weave Niti-S nitinol stent specifically for the duodenum. A key outcome in this palliative procedure was a significant improvement in global health status and median 82-day survival. The authors report a marvelous technical and robust clinical success rate with patency up to 190 days, and a 25% complication rate. [32]

In a 2014 study designed to compare the outcomes of endoscopic enteral stent insertion for malignant gastric outlet obstruction in older (≥65 years; n = 26) versus younger (n = 56) patients, Mansoor and Zeb reported comparable rates of technical success (100% in older patients vs 97% in younger patients) and clinical success in the two groups. [33] The complication rates were also comparable (27% in older patients vs 23% in younger patients).

The role of prophylactic gastrojejunostomy in cases of malignant GOO is a question that remains to be answered. Some surgeons argue that prophylactic gastrojejunostomy may increase postoperative morbidity, primarily due to delayed gastric emptying.

This issue was addressed in a study by Lillemoe and Cameron, [15]  in which 87 patients with unresectable periampullary cancer were randomized to receive or not receive a prophylactic gastrojejunostomy. Although there were no significant differences in morbidity, length of hospital stay, and survival rates, the prophylactic gastrojejunostomy group had a 0% (0/44) incidence of GOO versus 19% (8/43) in the other group. The authors concluded that prophylactic gastrojejunostomy significantly decreased the incidence of late GOO and should be performed routinely when a patient is undergoing surgical palliation for periampullary cancer. Comparable data are supported by other series.

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Postoperative Care

Admit patients to a monitor unit after the procedure. Pay special attention to fluid and electrolyte status.

Most surgeons agree that perioperative antibiotics are advisable but may be limited to use during the immediate perioperative period in the absence of intervening infection.

If a gastric reconstruction is performed, NG intubation is recommended. How long the tube should remain in place is controversial; however, it is important to remember that a previously dilated stomach, the performance of a vagotomy, and the presence of metastatic cancer may all contribute to decreased gastric motility. An anatomically patent gastrojejunostomy may fail to empty for days. This syndrome of delayed gastric emptying is a well-known entity and requires surgical patience. Again, preoperative planning for feeding access becomes important during this immediate postoperative period.

Aggressive pulmonary toilet, prophylaxis for gastritis and deep vein thrombosis (DVT), and early ambulation are advisable.

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Complications

Although the risk is small, patients undergoing endoscopic treatment with either balloon dilatation or stenting are at risk for perforation. Several literature reports exist regarding migration of the stents and reocclusion requiring further intervention.

Operative complications in patients undergoing surgery for GOO often are related to the nutritional status of the patients. Commencing nutritional support upon recognition of the presence of GOO is important. If surgery is anticipated, delaying the surgery or any intervention until TPN has been instituted for at least 1 week is often prudent.

Acute intervention may be technically difficult because of significant gastric dilatation and gastric wall edema. This circumstance may increase the rate of anastomotic leak. On occasion, delaying surgical intervention for several days while the stomach is decompressed by nasogastric suction may be prudent.

Alert patients undergoing gastric resection for benign or malignant disease to the possibility of well-known postgastrectomy syndromes, such as dumping, alkaline gastritis, and afferent loop syndrome. Severe symptoms may be present in 1-2% of patients.

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Long-Term Monitoring

Closely monitor patients after surgery and upon discharge. [34] After relief of GOO, patients may continue to experience gastric dysmotility and may require medication to stimulate gastric emptying and motility.

In patients with malignancy, the potential for progressive and recurrent disease always remains. These patients should be monitored by a surgeon or an oncologist.

Closely monitor patients whose treatment consisted of balloon dilatation; most of these patients require subsequent dilatations to achieve satisfactory results.

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