Cervicitis Empiric Therapy 

Updated: Mar 09, 2016
  • Author: Thomas E Herchline, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Empiric Therapy Regimens

Empiric therapeutic regimens for cervicitis are outlined below, including presumptive treatment, treatment for recurrent and persistent cervicitis, and treatment for pregnant patients with nongonococcal cervicitis. [1, 2, 3, 4, 5, 6, 7, 8]

Presumptive treatment

See the list below:

Consider the addition of concurrent treatment for gonococcal infection if prevalence of gonorrhea is high in the patient population under assessment:

  • Ceftriaxone 250 mg IM in a single dose (strongly preferred) or

  • Ceftizoxime 500 mg IM in a single dose or

  • Cefotaxime 500 mg IM in a single dose or

  • Cefoxitin 2 g IM plus probenecid 1 g PO in a single dose

  • Fluoroquinolones should not be used as empiric therapy because of increasing resistance of Neisseria gonorrhoeae isolates [2, 4]

  • Oral cephalosporins are no longer recommended for gonococcal infections [6]

Recurrent and persistent cervicitis

See the list below:

  • Reevaluate for possible reexposure to a sexually transmitted disease, and reassess patient for potential bacterial vaginosis

  • Important to assess, manage, and treat partners

  • Management of persistent cervicitis of unknown etiology is undefined

Management of pregnant patients with nongonococcal cervicitis

See the list below: