Primary Myelofibrosis Differential Diagnoses

Updated: Jan 30, 2017
  • Author: Asheesh Lal, MBBS, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Diagnostic Considerations

Diagnose primary myelofibrosis with caution in patients with another malignancy. The bone marrow involvement in carcinomas or lymphomas may be associated with marrow fibrosis. In these situations, the fibrosis reverses after effective treatment of the underlying disease. Similarly, marrow fibrosis may result in cases of granulomatous involvement of the bone marrow, as in histoplasmosis and tuberculosis.

Performing testing for bcr:abl gene rearrangements is important to exclude chronic myelogenous leukemia. JAK2V617F mutation can be detected in approximately 50–60% of patients with primary myelofibrosis. [19, 20, 21]

Differential Diagnoses