Alpha2-Plasmin Inhibitor Deficiency Differential Diagnoses

Updated: Feb 24, 2022
  • Author: Olga Kozyreva, MD; Chief Editor: Perumal Thiagarajan, MD  more...
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Diagnostic Considerations

Other acquired causes of bleeding disorders are as follows:

  • Excess plasmin generated by use of thrombolytic drugs (tissue plasminogen activator [tPA], modified tPA, streptokinase, modified streptokinase, urokinase)

  • Excess plasmin generated by tumors that make activators (ie, acute promyelocytic leukemia, some lung cancers)

  • Acquired coagulopathies

  • Acquired platelet disorders

  • Hemophilias

  • Factor XIII deficiency

  • Disease leading to reductions in alpha 2-plasmin inhibitor (alpha 2-PI, a2-PI) levels (see Causes)

Differential Diagnoses