Alpha2-Plasmin Inhibitor Deficiency Questions & Answers

Updated: Feb 24, 2022
  • Author: Olga Kozyreva, MD; Chief Editor: Perumal Thiagarajan, MD  more...
  • Print
Questions & Answers

Overview

What is alpha 2-plasmin inhibitor deficiency?

What is the pathophysiology of alpha 2-plasmin inhibitor deficiency?

What is the prevalence of alpha 2-plasmin inhibitor deficiency in the US?

What is the mortality and morbidity associated with alpha 2-plasmin inhibitor deficiency?

What are the racial predilections of alpha 2-plasmin inhibitor deficiency?

What are the sexual predilections of alpha 2-plasmin inhibitor deficiency?

At what age do the clinical manifestations of alpha 2-plasmin inhibitor deficiency typically appear?

Presentation

Which clinical history findings are characteristic of alpha 2-plasmin inhibitor deficiency?

Which physical findings are characteristic of alpha 2-plasmin inhibitor deficiency?

What causes alpha 2-plasmin inhibitor deficiency?

What are the genetic causes of alpha 2-plasmin inhibitor deficiency?

What causes acquired alpha 2-plasmin inhibitor deficiency?

What causes acquired alpha 2-plasmin inhibitor deficiency in neonates?

What causes alpha 2-plasmin inhibitor deficiency during pregnancy?

What is the role of liver disease in the etiology of alpha 2-plasmin inhibitor deficiency?

What is the role of thrombolytic therapy in the etiology of alpha 2-plasmin inhibitor deficiency?

What is the role of cardiopulmonary bypass surgery in the etiology of alpha 2-plasmin inhibitor deficiency?

What is the role of supraceliac aortic clamping in the etiology of alpha 2-plasmin inhibitor deficiency?

What is the role of lung cancer in the etiology of alpha 2-plasmin inhibitor deficiency?

What is the role of arterial disease and atherosclerosis in the etiology of alpha 2-plasmin inhibitor deficiency?

What is the role of trauma in the etiology of alpha 2-plasmin inhibitor deficiency?

What is the role of hemodialysis in the etiology of alpha 2-plasmin inhibitor deficiency?

What is the role of acute leukemia in the etiology of alpha 2-plasmin inhibitor deficiency?

DDX

Which conditions are included in the differential diagnoses of alpha 2-plasmin inhibitor deficiency?

What are the differential diagnoses for Alpha2-Plasmin Inhibitor Deficiency?

Workup

What is the role of lab tests in the workup of alpha 2-plasmin inhibitor deficiency?

Which lab tests are performed in the initial routine workup for alpha 2-plasmin inhibitor deficiency include?

Which specialized lab tests are performed in the workup of alpha 2-plasmin inhibitor deficiency?

What is the role of imaging studies in the workup of alpha 2-plasmin inhibitor deficiency?

What should be evaluated prior to surgery in patients with alpha 2-plasmin inhibitor deficiency?

Treatment

How is alpha 2-plasmin inhibitor deficiency treated?

What is the role of antifibrinolytic drugs in the treatment of alpha 2-plasmin inhibitor deficiency?

What is the role of prophylactic platelet transfusion in the treatment of alpha 2-plasmin inhibitor deficiency?

What is the role of surgery in the treatment of alpha 2-plasmin inhibitor deficiency?

Which specialist consultations are beneficial to patients with alpha 2-plasmin inhibitor deficiency?

Which dietary modifications are used in the treatment of alpha 2-plasmin inhibitor deficiency?

Which activity modifications are used in the treatment of alpha 2-plasmin inhibitor deficiency?

Medications

What is the role of FFP in the treatment of alpha 2-plasmin inhibitor deficiency?

What is the role of PLAS+SD in the treatment of alpha 2-plasmin inhibitor deficiency?

What is the role of EACA in the treatment of alpha 2-plasmin inhibitor deficiency?

Which medications in the drug class Antihemophilic Agents are used in the treatment of Alpha2-Plasmin Inhibitor Deficiency?

Follow-up

What is included in the long-term monitoring of alpha 2-plasmin inhibitor deficiency?

When is inpatient care indicated for the treatment of alpha 2-plasmin inhibitor deficiency?

What is the role of oral antifibrinolytics in the treatment of alpha 2-plasmin inhibitor deficiency?

When is patient transfer indicated in the treatment of alpha 2-plasmin inhibitor deficiency?

How is alpha 2-plasmin inhibitor deficiency prevented?

What are the possible complications of alpha 2-plasmin inhibitor deficiency?

What is the prognosis of alpha 2-plasmin inhibitor deficiency?

What is included in patient education about alpha 2-plasmin inhibitor deficiency?