Overview
What is alpha 2-plasmin inhibitor deficiency?
What is the pathophysiology of alpha 2-plasmin inhibitor deficiency?
What is the prevalence of alpha 2-plasmin inhibitor deficiency in the US?
What is the mortality and morbidity associated with alpha 2-plasmin inhibitor deficiency?
What are the racial predilections of alpha 2-plasmin inhibitor deficiency?
What are the sexual predilections of alpha 2-plasmin inhibitor deficiency?
At what age do the clinical manifestations of alpha 2-plasmin inhibitor deficiency typically appear?
Presentation
Which clinical history findings are characteristic of alpha 2-plasmin inhibitor deficiency?
Which physical findings are characteristic of alpha 2-plasmin inhibitor deficiency?
What causes alpha 2-plasmin inhibitor deficiency?
What are the genetic causes of alpha 2-plasmin inhibitor deficiency?
What causes acquired alpha 2-plasmin inhibitor deficiency?
What causes acquired alpha 2-plasmin inhibitor deficiency in neonates?
What causes alpha 2-plasmin inhibitor deficiency during pregnancy?
What is the role of liver disease in the etiology of alpha 2-plasmin inhibitor deficiency?
What is the role of thrombolytic therapy in the etiology of alpha 2-plasmin inhibitor deficiency?
What is the role of lung cancer in the etiology of alpha 2-plasmin inhibitor deficiency?
What is the role of trauma in the etiology of alpha 2-plasmin inhibitor deficiency?
What is the role of hemodialysis in the etiology of alpha 2-plasmin inhibitor deficiency?
What is the role of acute leukemia in the etiology of alpha 2-plasmin inhibitor deficiency?
DDX
Which conditions are included in the differential diagnoses of alpha 2-plasmin inhibitor deficiency?
What are the differential diagnoses for Alpha2-Plasmin Inhibitor Deficiency?
Workup
What is the role of lab tests in the workup of alpha 2-plasmin inhibitor deficiency?
Which specialized lab tests are performed in the workup of alpha 2-plasmin inhibitor deficiency?
What is the role of imaging studies in the workup of alpha 2-plasmin inhibitor deficiency?
What should be evaluated prior to surgery in patients with alpha 2-plasmin inhibitor deficiency?
Treatment
How is alpha 2-plasmin inhibitor deficiency treated?
What is the role of antifibrinolytic drugs in the treatment of alpha 2-plasmin inhibitor deficiency?
What is the role of surgery in the treatment of alpha 2-plasmin inhibitor deficiency?
Which specialist consultations are beneficial to patients with alpha 2-plasmin inhibitor deficiency?
Which dietary modifications are used in the treatment of alpha 2-plasmin inhibitor deficiency?
Which activity modifications are used in the treatment of alpha 2-plasmin inhibitor deficiency?
Medications
What is the role of FFP in the treatment of alpha 2-plasmin inhibitor deficiency?
What is the role of PLAS+SD in the treatment of alpha 2-plasmin inhibitor deficiency?
What is the role of EACA in the treatment of alpha 2-plasmin inhibitor deficiency?
Follow-up
What is included in the long-term monitoring of alpha 2-plasmin inhibitor deficiency?
When is inpatient care indicated for the treatment of alpha 2-plasmin inhibitor deficiency?
What is the role of oral antifibrinolytics in the treatment of alpha 2-plasmin inhibitor deficiency?
When is patient transfer indicated in the treatment of alpha 2-plasmin inhibitor deficiency?
How is alpha 2-plasmin inhibitor deficiency prevented?
What are the possible complications of alpha 2-plasmin inhibitor deficiency?
What is the prognosis of alpha 2-plasmin inhibitor deficiency?
What is included in patient education about alpha 2-plasmin inhibitor deficiency?
-
The role of alpha2-plasmin inhibitor (alpha2-antiplasmin) in fibrinolysis.