Chronic Myelogenous Leukemia (CML) Questions & Answers

Updated: May 23, 2021
  • Author: Emmanuel C Besa, MD; Chief Editor: Sara J Grethlein, MD, FACP  more...
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Questions & Answers

Overview

How is chronic myelogenous leukemia (CML) characterized?

What are the signs and symptoms of chronic myelogenous leukemia (CML)?

What are the signs and symptoms of progressive myelogenous leukemia (CML)?

How is chronic myelogenous leukemia (CML) diagnosed?

Which lab tests are performed in the workup of chronic myelogenous leukemia (CML)?

Which blood count and peripheral smear findings suggest chronic myelogenous leukemia (CML)?

Which bone marrow findings suggest chronic myelogenous leukemia (CML)?

What are the goals of treatment of chronic myelogenous leukemia (CML)?

Which medications are used in the treatment of chronic myelogenous leukemia (CML)?

What is the role of allogeneic bone marrow transplantation (BMT) or stem cell transplantation in the treatment of chronic myelogenous leukemia (CML)?

What is supportive care for chronic myelogenous leukemia (CML)?

What is chronic myelogenous leukemia (CML)?

What is the pathophysiology of chronic myelogenous leukemia (CML)?

What is the prevalence of chronic myelogenous leukemia (CML)?

What is the prognosis of chronic myelogenous leukemia (CML)?

How is chronic myelogenous leukemia (CML) staged?

Which scores are used to determine the prognosis for chronic myelogenous leukemia (CML)?

What a combined prognostic model for chronic myelogenous leukemia (CML)?

What are the clinical and lab poor prognostic factors for chronic myelogenous leukemia (CML)?

Which therapy-associated factors may indicate a poor prognosis of chronic myelogenous leukemia (CML)?

What is the median survival according to treatment used in chronic myelogenous leukemia (CML)?

What is the efficacy of imatinib in the treatment of chronic myelogenous leukemia (CML)?

How do additional chromosomal abnormalities (ACAs) affect the prognosis of chronic myelogenous leukemia (CML)?

Where can patients find information about chronic myelogenous leukemia (CML)?

Presentation

Which clinical history findings are characteristic of chronic myelogenous leukemia (CML)?

Which physical findings are characteristic of chronic myelogenous leukemia (CML)?

DDX

Which conditions are included in the differential diagnoses of chronic myelogenous leukemia (CML)?

What are the differential diagnoses for Chronic Myelogenous Leukemia (CML)?

Workup

How is chronic myelogenous leukemia (CML) diagnosed?

What is the role of blood count and peripheral smear in the workup of chronic myelogenous leukemia (CML)?

What is the role of bone marrow analysis in the workup of chronic myelogenous leukemia (CML)?

Treatment

What is the goal of treatment for chronic myelogenous leukemia (CML)?

How is chronic myelogenous leukemia (CML) treated?

What is the role of imatinib mesylate in the treatment of chronic myelogenous leukemia (CML)?

How is the choice of (TKI) made for the treatment of chronic myelogenous leukemia (CML)?

What is the role of second-generation TKIs in the treatment of chronic myelogenous leukemia (CML)?

What is the role of dasatinib in the treatment of chronic myelogenous leukemia (CML)?

What is the role of nilotinib in the treatment of chronic myelogenous leukemia (CML)?

What is the role of bosutinib in the treatment of chronic myelogenous leukemia (CML)?

What is the role of ponatinib in the treatment of chronic myelogenous leukemia (CML)?

Which factors should be weighed in the selection of in the selection of a specific tyrosine kinase inhibitor (TKI) to treat chronic myelogenous leukemia (CML)?

What is the role of protein translation inhibitors in the treatment of chronic myelogenous leukemia (CML)?

What is the role of myelosuppressive therapy in the treatment of chronic myelogenous leukemia (CML)?

What is the role of hydroxyurea in the treatment of chronic myelogenous leukemia (CML)?

What is the role of busulfan in the treatment of chronic myelogenous leukemia (CML)?

What is the role of leukapheresis in the treatment of chronic myelogenous leukemia (CML)?

What is the role of interferon alfa in the treatment of chronic myelogenous leukemia (CML)?

What is the role of allogeneic bone marrow transplantation (BMT) in the treatment of chronic myelogenous leukemia (CML)?

What are the mortality rates for chronic myelogenous leukemia (CML) following allogeneic BMT?

What is the role of splenectomy in the treatment of chronic myelogenous leukemia (CML)?

What causes the BCR-ABL PCR result to rise in patients with chronic myelogenous leukemia (CML)?

What is included in long-term monitoring of chronic myelogenous leukemia (CML)?

What are the standard therapeutic milestones achieved following treatment of chronic myelogenous leukemia (CML)?

What are the indications for BCR/ABL mutation screening in patients with chronic myelogenous leukemia (CML)?

What is the recommended interval for peripheral blood testing in patients with chronic myelogenous leukemia (CML)?

When should tyrosine kinase inhibitor (TKI) therapy be discontinued for chronic myelogenous leukemia (CML)?

Guidelines

What organizations have issued guidelines on the treatment of chronic myelogenous leukemia (CML)?

What are treatment guidelines for chronic-phase chronic myelogenous leukemia (CML)?

What are the treatment guidelines for accelerated-phase chronic myelogenous leukemia (CML)?

What are the treatment guidelines for blast-phase chronic myelogenous leukemia (CML)?

Which tests are recommended by the guidelines for monitoring response to tyrosine kinase inhibitor (TKI) therapy of chronic myelogenous leukemia (CML)?

What are the NCCN guidelines desired responses to first-line treatment for chronic myelogenous leukemia (CML)?

What are the ELN guidelines optimal responses to first-line treatment of chronic myelogenous leukemia (CML)?

What are the ESMO guidelines concerning optimal responses to first-line treatment of chronic myelogenous leukemia (CML)?

Medications

What is the role of medications in the treatment of chronic myelogenous leukemia (CML)?

Which medications in the drug class Interferons are used in the treatment of Chronic Myelogenous Leukemia (CML)?

Which medications in the drug class Tyrosine Kinase Inhibitors are used in the treatment of Chronic Myelogenous Leukemia (CML)?

Which medications in the drug class Antineoplastic Agents are used in the treatment of Chronic Myelogenous Leukemia (CML)?