Knee Injection Questions & Answers

1. Boon AJ, Smith J, Dahm DL, Sorenson EJ, Larson DR, Fitz-Gibbon PD, et al. Efficacy of intra-articular botulinum toxin type A in painful knee osteoarthritis: a pilot study. PM R. 2010 Apr. 2 (4):268-76. [QxMD MEDLINE Link].

2. Wang-Saegusa A, Cugat R, Ares O, Seijas R, Cuscó X, Garcia-Balletbó M. Infiltration of plasma rich in growth factors for osteoarthritis of the knee short-term effects on function and quality of life. Arch Orthop Trauma Surg. 2011 Mar. 131 (3):311-7. [QxMD MEDLINE Link].

3. Sampson S, Reed M, Silvers H, Meng M, Mandelbaum B. Injection of platelet-rich plasma in patients with primary and secondary knee osteoarthritis: a pilot study. Am J Phys Med Rehabil. 2010 Dec. 89 (12):961-9. [QxMD MEDLINE Link].

4. Chou CL, Lee SH, Lu SY, Tsai KL, Ho CY, Lai HC. Therapeutic effects of intra-articular botulinum neurotoxin in advanced knee osteoarthritis. J Chin Med Assoc. 2010 Nov. 73 (11):573-80. [QxMD MEDLINE Link].

5. Conti F, Priori R, Chimenti MS, Coari G, Annovazzi A, Valesini G, et al. Successful treatment with intraarticular infliximab for resistant knee monarthritis in a patient with spondylarthropathy: a role for scintigraphy with 99mTc-infliximab. Arthritis Rheum. 2005 Apr. 52 (4):1224-6. [QxMD MEDLINE Link].

6. Hinton R, Moody RL, Davis AW, Thomas SF. Osteoarthritis: diagnosis and therapeutic considerations. Am Fam Physician. 2002 Mar 1. 65 (5):841-8. [QxMD MEDLINE Link].

7. Ward EE, Jacobson JA, Fessell DP, Hayes CW, van Holsbeeck M. Sonographic detection of Baker's cysts: comparison with MR imaging. AJR Am J Roentgenol. 2001 Feb. 176 (2):373-80. [QxMD MEDLINE Link].

8. Schumacher HR Jr. Aspiration and injection therapies for joints. Arthritis Rheum. 2003 Jun 15. 49 (3):413-20. [QxMD MEDLINE Link].

9. Schumacher HR, Chen LX. Injectable corticosteroids in treatment of arthritis of the knee. Am J Med. 2005 Nov. 118 (11):1208-14. [QxMD MEDLINE Link].

10. Bellamy N, Campbell J, Robinson V, Gee T, Bourne R, Wells G. Intraarticular corticosteroid for treatment of osteoarthritis of the knee. Cochrane Database Syst Rev. 2006 Apr 19. CD005328. [QxMD MEDLINE Link].

11. Eder L, Chandran V, Ueng J, Bhella S, Lee KA, Rahman P, et al. Predictors of response to intra-articular steroid injection in psoriatic arthritis. Rheumatology (Oxford). 2010 Jul. 49 (7):1367-73. [QxMD MEDLINE Link].

12. McMahon AM, Tattersall R. Diagnosing juvenile idiopathic arthritis. Paediatrics and Child Health. 2011. 21:12:552-557.

13. Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO 3rd, et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 2010 Sep. 62 (9):2569-81. [QxMD MEDLINE Link].

14. Eggebeen AT. Gout: an update. Am Fam Physician. 2007 Sep 15. 76 (6):801-8. [QxMD MEDLINE Link].

15. [Guideline] Ringold S, Angeles-Han ST, Beukelman T, Lovell D, Cuello CA, Becker ML, et al. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Non-Systemic Polyarthritis, Sacroiliitis, and Enthesitis. Arthritis Rheumatol. 2019 Jun. 71 (6):846-863. [QxMD MEDLINE Link]. [Full Text].

16. McAlindon TE, LaValley MP, Harvey WF, Price LL, Driban JB, Zhang M, et al. Effect of Intra-articular Triamcinolone vs Saline on Knee Cartilage Volume and Pain in Patients With Knee Osteoarthritis: A Randomized Clinical Trial. JAMA. 2017 May 16. 317 (19):1967-1975. [QxMD MEDLINE Link].

17. Briem K, Axe MJ, Snyder-Mackler L. Functional and perceived response to intra-articular hyaluronan injection in patients with knee osteoarthritis: persistence of treatment effects over 5 months. Knee Surg Sports Traumatol Arthrosc. 2009 Jul. 17 (7):763-9. [QxMD MEDLINE Link].

18. Akeda K, An HS, Okuma M, Attawia M, Miyamoto K, Thonar EJ, et al. Platelet-rich plasma stimulates porcine articular chondrocyte proliferation and matrix biosynthesis. Osteoarthritis Cartilage. 2006 Dec. 14 (12):1272-80. [QxMD MEDLINE Link].

19. Kon E, Mandelbaum B, Buda R, Filardo G, Delcogliano M, Timoncini A, et al. Platelet-rich plasma intra-articular injection versus hyaluronic acid viscosupplementation as treatments for cartilage pathology: from early degeneration to osteoarthritis. Arthroscopy. 2011 Nov. 27 (11):1490-501. [QxMD MEDLINE Link].

20. Lockman LE. Practice tips. Knee joint injections and aspirations: the triangle technique. Can Fam Physician. 2006 Nov. 52 (11):1403-4. [QxMD MEDLINE Link].

21. Richette P, Chevalier X, Ea HK, Eymard F, Henrotin Y, Ornetti P, et al. Hyaluronan for knee osteoarthritis: an updated meta-analysis of trials with low risk of bias. RMD Open. 2015. 1 (1):e000071. [QxMD MEDLINE Link].

22. Jüni P, Hari R, Rutjes AW, Fischer R, Silletta MG, Reichenbach S, et al. Intra-articular corticosteroid for knee osteoarthritis. Cochrane Database Syst Rev. 2015 Oct 22. 10:CD005328. [QxMD MEDLINE Link].

23. Meheux CJ, McCulloch PC, Lintner DM, Varner KE, Harris JD. Efficacy of Intra-articular Platelet-Rich Plasma Injections in Knee Osteoarthritis: A Systematic Review. Arthroscopy. 2016 Mar. 32 (3):495-505. [QxMD MEDLINE Link].

24. Filardo G, Kon E, Pereira Ruiz MT, Vaccaro F, Guitaldi R, Di Martino A, et al. Platelet-rich plasma intra-articular injections for cartilage degeneration and osteoarthritis: single- versus double-spinning approach. Knee Surg Sports Traumatol Arthrosc. 2012 Oct. 20 (10):2082-91. [QxMD MEDLINE Link].

25. Mazzocca AD, McCarthy MB, Chowaniec DM, Cote MP, Romeo AA, Bradley JP, et al. Platelet-rich plasma differs according to preparation method and human variability. J Bone Joint Surg Am. 2012 Feb 15. 94 (4):308-16. [QxMD MEDLINE Link].

26. Rifat SF, Moeller JL. Site-specific techniques of joint injection. Useful additions to your treatment repertoire. Postgrad Med. 2001 Mar. 109 (3):123-6, 129-30, 135-6. [QxMD MEDLINE Link].

27. Rifat SF, Moeller JL. Basics of joint injection. General techniques and tips for safe, effective use. Postgrad Med. 2001 Jan. 109 (1):157-60, 165-6. [QxMD MEDLINE Link].

28. McNeil JD. Intra-articular hyaluronic acid preparations for use in the treatment of osteoarthritis. Int J Evid Based Healthc. 2011 Sep. 9 (3):261-4. [QxMD MEDLINE Link].

Quan Dang Le, MD Pain Fellow, Louisiana State University School of Medicine in New Orleans; Former Clinical Assistant Professor, Department of Medicine, Section of Physical Medicine and Rehabilitation, Louisiana State University School of Medicine in New Orleans

Quan Dang Le, MD is a member of the following medical societies: American Academy of Physical Medicine and Rehabilitation

Disclosure: Nothing to disclose.

Stephen Kishner, MD, MHA Clinical Professor, Louisiana State University School of Medicine in New Orleans

Stephen Kishner, MD, MHA is a member of the following medical societies: American Academy of Physical Medicine and Rehabilitation, American Association of Neuromuscular and Electrodiagnostic Medicine

Disclosure: Nothing to disclose.

Christian D Clasby, MD Resident Physician, Department of Physician Medicine and Rehabilitation, Louisiana State University School of Medicine in New Orleans

Disclosure: Nothing to disclose.

Navneet Sharma, MD Physician, Department of Physical Medicine and Rehabilitation, Louisiana State University School of Medicine in New Orleans

Navneet Sharma, MD is a member of the following medical societies: American Academy of Physical Medicine and Rehabilitation, American Medical Association, Louisiana State Medical Society

Disclosure: Nothing to disclose.

Thomas M DeBerardino, MD, FAAOS, FAOA Professor of Orthopaedic Surgery, University of Texas Health Science Center at San Antonio, Joe R and Teresa Lozano Long School of Medicine; Professor of Orthopaedic Surgery and Faculty of Sports Medicine Fellowship, Baylor College of Medicine; Sports Medicine Orthopaedic Surgeon, Department of Orthopaedics, UT Health San Antonio; Consulting Surgeon, Sports Medicine, Arthroscopy and Reconstruction of the Knee, Hip and Shoulder

Thomas M DeBerardino, MD, FAAOS, FAOA is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American Orthopaedic Association, American Orthopaedic Society for Sports Medicine, Arthroscopy Association of North America, Clinical Orthopaedic Society, Herodicus Society, International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: Arthrex, Inc.; MTF; Aesculap; Conmed; JRF<br/>Received research grant from: Arthrex, Inc.; MTF.

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