Erythromelalgia Medication

Updated: Jul 31, 2017
  • Author: Antoine N Saliba, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Medication

Medication Summary

Platelet inhibition is helpful in patients with thrombocytosis. Aspirin is most often used, but anagrelide may also be effective. [39] The optimal pharmacologic therapy in primary erythromelalgia is still unknown.

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Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

Class Summary

Aspirin is preferred because it provides relief lasting longer than that of indomethacin or other nonsteroidal anti-inflammatory drugs (NSAIDs), presumably because of irreversible platelet inhibition.

Aspirin

Aspirin inhibits prostaglandin synthesis, which prevents formation of platelet-aggregating thromboxane A2.

Anagrelide (Agrylin)

Anagrelide may inhibit cyclic nucleotide phosphodiesterase and the release of arachidonic acid from phospholipase possibly by inhibiting phospholipase A2. A decrease in megakaryocyte hypermaturation may result in a reduction in platelet production.

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