Glanzmann Thrombasthenia Clinical Presentation

Updated: Mar 18, 2021
  • Author: Zonera Ashraf Ali, MBBS; Chief Editor: Srikanth Nagalla, MD, MS, FACP  more...
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The history in patients with Glanzmann thrombasthenia may include the following:

  • Excessive bleeding after dental extraction (this may often be the first sign of the disease)
  • Petechiae and ecchymoses (although spontaneous petechiae are uncommon)
  • Menorrhagia, often worse at menarche
  • Gingival bleeding (worse with poor dental hygiene)
  • Hemarthroses (rare)
  • Family history of a bleeding disorder may or may not exist
  • Gastrointestinal bleeding or hematuria is less common

In patients suspected of Glanzmann thrombasthenia, examine the skin and oral mucosa for petechiae, ecchymoses, and any current bleeding. The spleen should normally be nonpalpable.