Glanzmann Thrombasthenia Clinical Presentation

Updated: Dec 29, 2017
  • Author: Zonera Ashraf Ali, MBBS; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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The clinical history of Glanzmann thrombasthenia may include the following:

  • Excessive bleeding after dental extraction (this may often be the first sign of the disease)

  • Petechiae and ecchymoses (although spontaneous petechiae are uncommon)

  • Menorrhagia, often worse at menarche

  • Gingival bleeding (which is worse with poor dental hygiene)

  • Hemarthroses (rare)

  • Family history of a bleeding disorder may or may not exist

  • Gastrointestinal bleeding or hematuria is less common



See the list below:

  • In patients suspected with of Glanzmann thrombasthenia, examine the skin and oral mucosa for petechiae, ecchymoses, and any current bleeding.

  • The spleen should normally be nonpalpable.



See the list below:

  • Glanzmann thrombasthenia is a genetic condition. The disease is clinically apparent in patients who are homozygous. Glanzmann thrombasthenia is normally of no clinical significance in patients who are heterozygous for this condition.

  • Rare acquired forms caused by antibodies against αIIb β3 integrin have been described. One such affected patient developed non-Hodgkin lymphoma, [2, 11] and another had no underlying cause. [11] It has also been described with hairy cell leukemia. [12]