Glanzmann Thrombasthenia Clinical Presentation

Updated: Dec 29, 2017
  • Author: Zonera Ashraf Ali, MBBS; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Presentation

History

The clinical history of Glanzmann thrombasthenia may include the following:

  • Excessive bleeding after dental extraction (this may often be the first sign of the disease)
  • Petechiae and ecchymoses (although spontaneous petechiae are uncommon)
  • Menorrhagia, often worse at menarche
  • Gingival bleeding (which is worse with poor dental hygiene)
  • Hemarthroses (rare)
  • Family history of a bleeding disorder may or may not exist
  • Gastrointestinal bleeding or hematuria is less common
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Physical

See the list below:

  • In patients suspected with of Glanzmann thrombasthenia, examine the skin and oral mucosa for petechiae, ecchymoses, and any current bleeding.
  • The spleen should normally be nonpalpable.
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Causes

See the list below:

  • Glanzmann thrombasthenia is a genetic condition. The disease is clinically apparent in patients who are homozygous. Glanzmann thrombasthenia is normally of no clinical significance in patients who are heterozygous for this condition.
  • Rare acquired forms caused by antibodies against αIIb β3 integrin have been described. One such affected patient developed non-Hodgkin lymphoma, [2, 11] and another had no underlying cause. [11] It has also been described with hairy cell leukemia. [12]
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