Glanzmann Thrombasthenia Differential Diagnoses

1. Krause KA, Graham BC. Glanzmann Thrombasthenia. 2021 Jan. [QxMD MEDLINE Link]. [Full Text].

2. Nurden AT. Acquired Glanzmann thrombasthenia: From antibodies to anti-platelet drugs. Blood Rev. 2019 Jul. 36:10-22. [QxMD MEDLINE Link].

3. Mohan G, Malayala SV, Mehta P, Balla M. A Comprehensive Review of Congenital Platelet Disorders, Thrombocytopenias and Thrombocytopathies. Cureus. 2020 Oct 31. 12 (10):e11275. [QxMD MEDLINE Link]. [Full Text].

4. Huang J, Li X, Shi X, Zhu M, Wang J, Huang S, et al. Platelet integrin αIIbβ3: signal transduction, regulation, and its therapeutic targeting. J Hematol Oncol. 2019 Mar 7. 12 (1):26. [QxMD MEDLINE Link]. [Full Text].

5. Nurden AT, Fiore M, Nurden P, Pillois X. Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models. Blood. 2011 Dec 1. 118(23):5996-6005. [QxMD MEDLINE Link].

6. Nurden AT. Acquired Glanzmann thrombasthenia: From antibodies to anti-platelet drugs. Blood Rev. 2019 Jul. 36:10-22. [QxMD MEDLINE Link].

7. Nurden AT, Pillois X. ITGA2B and ITGB3 gene mutations associated with Glanzmann thrombasthenia. Platelets. 2018 Jan. 29 (1):98-101. [QxMD MEDLINE Link]. [Full Text].

8. Tholouli E, Hay CR, O'Gorman P, Makris M. Acquired Glanzmann's thrombasthenia without thrombocytopenia: a severe acquired autoimmune bleeding disorder. Br J Haematol. 2004 Oct. 127(2):209-13. [QxMD MEDLINE Link].

9. Kannan M, Chatterjee T, Ahmad F, Kumar R, Choudhry VP, Saxena R. Acquired Glanzmann's thrombasthenia associated with Hairy cell leukaemia. Eur J Clin Invest. 2009 Dec. 39(12):1110-1. [QxMD MEDLINE Link].

10. Fiore M, Pillois X, Nurden P, Nurden AT, Austerlitz F. Founder effect and estimation of the age of the French Gypsy mutation associated with Glanzmann thrombasthenia in Manouche families. Eur J Hum Genet. 2011 Sep. 19(9):981-7. [QxMD MEDLINE Link]. [Full Text].

11. Siddiq S, Clark A, Mumford A. A systematic review of the management and outcomes of pregnancy in Glanzmann thrombasthenia. Haemophilia. 2011 Sep. 17(5):e858-69. [QxMD MEDLINE Link].

12. King LJ, Huff J, Heber D, Miller MA, Marshall B. Management of Refractory Menstrual Bleeding in an Adolescent with Glanzmann Thrombasthenia: A Case Report and Review. Case Rep Obstet Gynecol. 2020. 2020:8848763. [QxMD MEDLINE Link]. [Full Text].

13. Chitlur M, Rajpurkar M, Recht M, Tarantino MD, Yee DL, Cooper DL, et al. Recognition and management of platelet-refractory bleeding in patients with Glanzmann's thrombasthenia and other severe platelet function disorders. Int J Gen Med. 2017. 10:95-99. [QxMD MEDLINE Link]. [Full Text].

14. Rajpurkar M, Chitlur M, Recht M, Cooper DL. Use of recombinant activated factor VII in patients with Glanzmann's thrombasthenia: a review of the literature. Haemophilia. 2014 Jul. 20(4):464-71. [QxMD MEDLINE Link].

15. Poon MC, Di Minno G, d'Oiron R, Zotz R. New Insights Into the Treatment of Glanzmann Thrombasthenia. Transfus Med Rev. 2016 Apr. 30 (2):92-9. [QxMD MEDLINE Link]. [Full Text].

16. Di Minno G, Zotz RB, d'Oiron R, Bindslev N, Di Minno MN, Poon MC, et al. The international, prospective Glanzmann Thrombasthenia Registry: treatment modalities and outcomes of non-surgical bleeding episodes in patients with Glanzmann thrombasthenia. Haematologica. 2015 Aug. 100 (8):1031-7. [QxMD MEDLINE Link]. [Full Text].

17. Poon MC, d'Oiron R, Zotz RB, Bindslev N, Di Minno MN, Di Minno G, et al. The international, prospective Glanzmann Thrombasthenia Registry: treatment and outcomes in surgical intervention. Haematologica. 2015 Aug. 100 (8):1038-44. [QxMD MEDLINE Link]. [Full Text].

18. Fiore M, d'Oiron R, Pillois X, Alessi MC. Anti-α_IIb β₃ immunization in Glanzmann thrombasthenia: review of literature and treatment recommendations. Br J Haematol. 2018 Apr. 181 (2):173-182. [QxMD MEDLINE Link]. [Full Text].

19. Bannow BS, Konkle BA. Inherited Bleeding Disorders in the Obstetric Patient. Transfus Med Rev. 2018 Oct. 32 (4):237-243. [QxMD MEDLINE Link].

20. George JN, Caen JP, Nurden AT. Glanzmann's thrombasthenia: the spectrum of clinical disease. Blood. 1990 Apr 1. 75(7):1383-95. [QxMD MEDLINE Link]. [Full Text].

21. Nurden AT. Glanzmann thrombasthenia. Orphanet J Rare Dis. 2006 Apr 6. 1:10. [QxMD MEDLINE Link]. [Full Text].

22. Poon MC, Zotz R, Di Minno G, et al. Glanzmann's thrombasthenia treatment: a prospective observational registry on the use of recombinant human activated factor VII and other hemostatic agents. Semin Hematol. 2006 Jan. 43(1 suppl 1):S33-6. [QxMD MEDLINE Link].

23. Poon MC. Clinical use of recombinant human activated factor VII (rFVIIa) in the prevention and treatment of bleeding episodes in patients with Glanzmann's thrombasthenia. Vasc Health Risk Manag. 2007. 3(5):655-64. [QxMD MEDLINE Link]. [Full Text].

24. Saxena R, Kannan M. Glanzmann's thrombasthenia: an overview. Clin Appl Thromb Hemost. 2008 Oct 16. epub ahead of print. [QxMD MEDLINE Link].

25. van de Vijver E, De Cuyper IM, Gerrits AJ, Verhoeven AJ, Seeger K, Gutiérrez L, et al. Defects in Glanzmann thrombasthenia and LAD-III (LAD-1/v) syndrome: the role of integrin ß1 and ß3 in platelet adhesion to collagen. Blood. 2011 Nov 7. [QxMD MEDLINE Link].

26. Ali N, Moiz B, Shaikh U, et al. Diagnostic tool for Glanzmann's thrombasthenia clinicopathologic spectrum. J Coll Physicians Surg Pak. 2008 Feb. 18(2):91-4. [QxMD MEDLINE Link].

27. Jin PP, Shen WZ, Yang F, et al. [Analysis of clinical features and genotype in three Chinese pedigrees with Glanzmann thrombasthenia]. Zhonghua Xue Ye Xue Za Zhi. 2008 Mar. 29(3):149-53. [QxMD MEDLINE Link].

28. Lombardo VT, Sottilotta G. Recombinant activated factor VII combined with desmopressin in preventing bleeding from dental extraction in a patient with Glanzmann's thrombasthenia. Clin Appl Thromb Hemost. 2006 Jan. 12(1):115-6. [QxMD MEDLINE Link].

29. Shen WZ, Ding QL, Jin PP, et al. A novel Pro126His beta propeller mutation in integrin alphaIIb causes Glanzmann thrombasthenia by impairing progression of pro-alphaIIbbeta3 from endoplasmic reticulum to Golgi. Blood Cells Mol Dis. 2008 Oct 29. epub ahead of print. [QxMD MEDLINE Link].

30. Solh M, Mescher C, Klappa A, Shah S, Zantek N, Datta Y. Acquired Glanzmann's thrombasthenia with optimal response to rituximab therapy. Am J Hematol. 2011 Aug. 86(8):715-6. [QxMD MEDLINE Link].

31. Vuckovic SA. Glanzmann's thrombasthenia revisited. J Emerg Med. 1996 May-Jun. 14(3):299-303. [QxMD MEDLINE Link].

Zonera Ashraf Ali, MBBS Consulting Staff, Main Line Oncology Hematology Associates, Lankenau Cancer Center

Zonera Ashraf Ali, MBBS is a member of the following medical societies: American Society of Clinical Oncology

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Marcel E Conrad, MD Distinguished Professor of Medicine (Retired), University of South Alabama College of Medicine

Marcel E Conrad, MD is a member of the following medical societies: Alpha Omega Alpha, American Association for the Advancement of Science, American Association of Blood Banks, American Chemical Society, American College of Physicians, American Physiological Society, American Society for Clinical Investigation, American Society of Hematology, Association of American Physicians, Association of Military Surgeons of the US, International Society of Hematology, Society for Experimental Biology and Medicine, SWOG

Disclosure: Partner received none from No financial interests for none.

Srikanth Nagalla, MD, MS, FACP Chief of Benign Hematology, Miami Cancer Institute, Baptist Health South Florida; Clinical Professor of Medicine, Florida International University, Herbert Wertheim College of Medicine

Srikanth Nagalla, MD, MS, FACP is a member of the following medical societies: American Society of Hematology, Association of Specialty Professors

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: Alexion; Alnylam; Kedrion; Sanofi; Dova; Apellis; Pharmacosmos<br/>Serve(d) as a speaker or a member of a speakers bureau for: Sobi; Sanofi; Rigel.

Wadie F Bahou, MD Chief, Division of Hematology, Hematology/Oncology Fellowship Director, Professor, Department of Internal Medicine, State University of New York at Stony Brook

Wadie F Bahou, MD is a member of the following medical societies: American Society of Hematology

Disclosure: Nothing to disclose.

Mark J Shumate, MD, MPH Assistant Professor, Department of Internal Medicine, Division of Hematology/Oncology, Emory University School of Medicine

Mark J Shumate, MD, MPH is a member of the following medical societies: American Society of Hematology

Disclosure: Nothing to disclose.

• Print this section
• Print the entire contents of
• Print the entire contents of article