Hairy Cell Leukemia Questions & Answers

Updated: Sep 16, 2018
  • Author: Emmanuel C Besa, MD; Chief Editor: Koyamangalath Krishnan, MD, FRCP, FACP  more...
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Questions & Answers

Overview

What is hairy cell leukemia (HCL)?

What is the pathophysiology of hairy cell leukemia (HCL)?

What is the prevalence of hairy cell leukemia (HCL)?

What is the prognosis of hairy cell leukemia (HCL)?

Presentation

Which clinical history findings are characteristic of hairy cell leukemia (HCL)?

Which systemic immunologic disorders are associated with hairy cell leukemia (HCL)?

Which physical findings are characteristic of hairy cell leukemia (HCL)?

DDX

How is hairy cell leukemia (HCL) differentiated from other peripheral small B-cell lymphoid neoplasms?

Which conditions are included in the differential diagnoses of hairy cell leukemia (HCL)?

What are the differential diagnoses for Hairy Cell Leukemia?

Workup

How is hairy cell leukemia (HCL) diagnosed?

What is the role of complete blood cell count (CBC) in the workup of hairy cell leukemia (HCL)?

What is the role of bone marrow aspiration in the diagnosis of hairy cell leukemia (HCL)?

What is the role of imaging studies in the workup of hairy cell leukemia (HCL)?

Which histologic findings are characteristic of hairy cell leukemia (HCL)?

Treatment

How is hairy cell leukemia (HCL) treated?

What are the indications for treatment of hairy cell leukemia (HCL)?

What is the role of cladribine in the treatment of hairy cell leukemia (HCL)?

How is refractory hairy cell leukemia (HCL) treated?

How is hairy cell leukemia (HCL) relapse treated?

What is the role of vemurafenib in the treatment of hairy cell leukemia (HCL)?

What is the role of surgery in the treatment of hairy cell leukemia (HCL)?

What is included in long-term monitoring of patients with hairy cell leukemia (HCL)?

Guidelines

Which organizations have released treatment guidelines for hairy cell leukemia (HCL)?

What are the NCCN diagnostic guidelines for hairy cell leukemia (HCL)?

What does the ESMO guidelines consider prognostic indicators for hairy cell leukemia (HCL)?

What are the NCCN guidelines for hairy cell leukemia (HCL) treatment?

What are the ESMO guidelines for hairy cell leukemia (HCL) treatment?

Medications

Which medications are used in the treatment of hairy cell leukemia (HCL)?

Which medications in the drug class Antineoplastics, Monoclonal Antibody are used in the treatment of Hairy Cell Leukemia?

Which medications in the drug class Recombinant Granulocyte Colony-Stimulating Factors (G-CSFs) are used in the treatment of Hairy Cell Leukemia?

Which medications in the drug class Interferons are used in the treatment of Hairy Cell Leukemia?

Which medications in the drug class Purine Analogues are used in the treatment of Hairy Cell Leukemia?