Hairy Cell Leukemia Questions & Answers

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10. Getta BM, Woo KM, Devlin S, Park JH, Abdel-Wahab O, Saven A, et al. Treatment outcomes and secondary cancer incidence in young patients with hairy cell leukaemia. Br J Haematol. 2016 Nov. 175 (3):402-409. [QxMD MEDLINE Link]. [Full Text].

11. Au WY, Klasa RJ, Gallagher R, et al. Second malignancies in patients with hairy cell leukemia in british columbia: a 20-year experience. Blood. 1998 Aug 15. 92(4):1160-4. [QxMD MEDLINE Link]. [Full Text].

12. Kurzrock R, Strom SS, Estey E, et al. Second cancer risk in hairy cell leukemia: analysis of 350 patients. J Clin Oncol. 1997 May. 15(5):1803-10. [QxMD MEDLINE Link].

13. Troussard X, Cornet E. Hairy cell leukemia 2018: Update on diagnosis, risk-stratification, and treatment. Am J Hematol. 2017 Dec. 92 (12):1382-1390. [QxMD MEDLINE Link]. [Full Text].

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15. [Guideline] National Comprehensive Cancer Network. NCCN Guidelines: Hairy Cell Leukemia. National Comprehensive Cancer Network. Available at https://www.nccn.org/professionals/physician_gls/pdf/hairy_cell.pdf. Version 1.2023 — August 30,2022; Accessed: October 22, 2022.

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17. [Guideline] Grever MR, Abdel-Wahab O, Andritsos LA, et al. Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia. Blood. 2017 Feb 2. 129 (5):553-560. [QxMD MEDLINE Link]. [Full Text].

18. Shao H, Calvo KR, Grönborg M, Tembhare PR, Kreitman RJ, Stetler-Stevenson M, et al. Distinguishing hairy cell leukemia variant from hairy cell leukemia: development and validation of diagnostic criteria. Leuk Res. 2013 Apr. 37 (4):401-409. [QxMD MEDLINE Link]. [Full Text].

19. Arcaini L, Zibellini S, Boveri E, et al. The BRAF V600E mutation in hairy cell leukemia and other mature B-cell neoplasms. Blood. 2012 Jan 5. 119(1):188-91. [QxMD MEDLINE Link].

20. Taylor J, Xiao W, Abdel-Wahab O. Diagnosis and classification of hematologic malignancies on the basis of genetics. Blood. 2017 Jul 27. 130 (4):410-423. [QxMD MEDLINE Link]. [Full Text].

21. Tiacci E, Schiavoni G, Forconi F, et al. Simple genetic diagnosis of hairy cell leukemia by sensitive detection of the BRAF-V600E mutation. Blood. 2012 Jan 5. 119(1):192-5. [QxMD MEDLINE Link].

22. Durham BH, Getta B, Dietrich S, Taylor J, Won H, Bogenberger JM, et al. Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations. Blood. 2017 Oct 5. 130 (14):1644-1648. [QxMD MEDLINE Link]. [Full Text].

23. Grever MR. How I treat hairy cell leukemia. Blood. 2010 Jan 7. 115(1):21-8. [QxMD MEDLINE Link].

24. Madanat YF, Rybicki L, Radivoyevitch T, Jagadeesh D, Dean R, Pohlman B, et al. Long-Term Outcomes of Hairy Cell Leukemia Treated With Purine Analogs: A Comparison With the General Population. Clin Lymphoma Myeloma Leuk. 2017 Dec. 17 (12):857-862. [QxMD MEDLINE Link].

25. Piro LD, Carrera CJ, Carson DA, Beutler E. Lasting remissions in hairy-cell leukemia induced by a single infusion of 2-chlorodeoxyadenosine. N Engl J Med. 1990 Apr 19. 322(16):1117-21. [QxMD MEDLINE Link].

26. Jehn U, Bartl R, Dietzfelbinger H, Haferlach T, Heinemann V. An update: 12-year follow-up of patients with hairy cell leukemia following treatment with 2-chlorodeoxyadenosine. Leukemia. 2004 Sep. 18(9):1476-81. [QxMD MEDLINE Link].

27. Saven A, Burian C, Adusumalli J, Koziol JA. Filgrastim for cladribine-induced neutropenic fever in patients with hairy cell leukemia. Blood. 1999 Apr 15. 93(8):2471-7. [QxMD MEDLINE Link].

28. Habermann TM, Andersen JW, Cassileth PA, Bennett JM, Oken MM. Sequential administration of recombinant interferon alpha and deoxycoformycin in the treatment of hairy cell leukaemia. Br J Haematol. 1992 Apr. 80(4):466-71. [QxMD MEDLINE Link].

29. Piro LD, Carrera CJ, Carson DA, Beutler E. Lasting remissions in hairy-cell leukemia induced by a single infusion of 2-chlorodeoxyadenosine. N Engl J Med. 1990 Apr 19. 322(16):1117-21. [QxMD MEDLINE Link].

30. Goodman GR, Burian C, Koziol JA, Saven A. Extended follow-up of patients with hairy cell leukemia after treatment with cladribine. J Clin Oncol. 2003 Mar 1. 21(5):891-6. [QxMD MEDLINE Link]. [Full Text].

31. Ganzel C, Gatt ME, Maly A, Ben-Yehuda D, Goldschmidt N. High incidence of skin rash in patients with hairy cell leukemia treated with cladribine. Leuk Lymphoma. 2011 Oct 31. [QxMD MEDLINE Link].

32. Chadha P, Rademaker AW, Mendiratta P, et al. Treatment of hairy cell leukemia with 2-chlorodeoxyadenosine (2-CdA): long-term follow-up of the Northwestern University experience. Blood. 2005 Jul 1. 106(1):241-6. [QxMD MEDLINE Link]. [Full Text].

33. Ravandi F, Jorgensen JL, O'Brien SM, et al. Eradication of minimal residual disease in hairy cell leukemia. Blood. 2006 Jun 15. 107(12):4658-62. [QxMD MEDLINE Link]. [Full Text].

34. Kreitman RJ, Arons E, Stetler-Stevenson M, Fitzgerald DJ, Wilson WH, Pastan I. Recombinant immunotoxins and other therapies for relapsed/refractory hairy cell leukemia. Leuk Lymphoma. 2011 Jun. 52 Suppl 2:82-6. [QxMD MEDLINE Link].

35. Flinn IW, Kopecky KJ, Foucar MK, et al. Long-term follow-up of remission duration, mortality, and second malignancies in hairy cell leukemia patients treated with pentostatin. Blood. 2000 Nov 1. 96(9):2981-6. [QxMD MEDLINE Link]. [Full Text].

36. Kreitman RJ, Dearden C, Zinzani PL, Delgado J, Karlin L, Robak T, et al. Moxetumomab pasudotox in relapsed/refractory hairy cell leukemia. Leukemia. 2018 Aug. 32 (8):1768-1777. [QxMD MEDLINE Link]. [Full Text].

37. Kreitman RJ, Fitzgerald DJ, Pastan I. Approach to the patient after relapse of hairy cell leukemia. Leuk Lymphoma. 2009 Oct. 50 Suppl 1:32-7. [QxMD MEDLINE Link].

38. Tiacci E, Park JH, De Carolis L, et al. Targeting Mutant BRAF in Relapsed or Refractory Hairy-Cell Leukemia. N Engl J Med. 2015 Oct 29. 373 (18):1733-47. [QxMD MEDLINE Link].

39. Rogers KA, Andritsos LA, Wei L, et al. Phase 2 study of ibrutinib in classic and variant hairy cell leukemia. Blood. 2021 Jun 24. 137 (25):3473-3483. [QxMD MEDLINE Link]. [Full Text].

40. [Guideline] Grever M, Andritsos L, Banerji V, et al. Hairy cell leukemia and COVID-19 adaptation of treatment guidelines. Leukemia. 2021 Jul. 35 (7):1864-1872. [QxMD MEDLINE Link]. [Full Text].

Emmanuel C Besa, MD Professor Emeritus, Department of Medicine, Division of Hematologic Malignancies and Hematopoietic Stem Cell Transplantation, Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University

Emmanuel C Besa, MD is a member of the following medical societies: American Association for Cancer Education, American Society of Clinical Oncology, American College of Clinical Pharmacology, American Federation for Medical Research, American Society of Hematology, New York Academy of Sciences

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Sara J Grethlein, MD, MBA, FACP Executive Medical Director and Medical Oncologist, Swedish Cancer Institute

Sara J Grethlein, MD, MBA, FACP is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians, American Medical Women's Association, American Society of Clinical Oncology, American Society of Hematology, Gold Humanism Honor Society, Leukemia and Lymphoma Society

Disclosure: Nothing to disclose.

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