Acute Myeloid Leukemia Staging 

Updated: Dec 30, 2015
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
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FAB and WHO Classifications for Acute Myeloid Leukemia

Two staging systems are commonly used for acute myeloid leukemia (AML). The French-American-British (FAB) classification system is based on morphology to define specific immunotypes. The World Health Organization (WHO) classification reviews chromosome translocations and evidence of dysplasia. [1]

Table. FAB classification of AML (Open Table in a new window)

FAB subtype

Name

Adult AML patients (%)

M0

Undifferentiated acute myeloblastic leukemia

5%

M1

Acute myeloblastic leukemia with minimal maturation

15%

M2

Acute myeloblastic leukemia with maturation

25%

M3

Acute promyelocytic leukemia

10%

M4

Acute myelomonocytic leukemia

20%

M4eos

Acute myelomonocytic leukemia with eosinophilia

5%

M5

Acute monocytic leukemia

10%

M6

Acute erythroid leukemia

5%

M7

Acute megakaryocytic leukemia

5%

WHO classification of AML and related neoplasms

AML with recurrent genetic abnormalities [2, 3] :

  • AML with t(8;21)(q22;q22); RUNX1-RUNX1T1

  • AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBEB-MYH11

  • Acute promyelocytic leukemia (APL) with t(15;17)(q22;q12); PML-RARA

  • AML with t(9;11)(p22;q23); MLLT3-MLL

  • AML with t(6;9)(p23;q34); DEK-NUP214

  • AML with inv(3)(q21q26.2) or t(3;3)(q21;q26.2); RPN1-EVI1

  • AML (megakaryoblastic) with t(1;22)(p13;q13); RBM15-MKL1

  • Provisional entity: AML with mutated NPM1

  • Provisional entity: AML with mutated CEBPA

AML with myelodysplasia-related change

Therapy-related myeloid neoplasms

AML, not otherwise specified:

  • Undifferentiated AML (M0)

  • AML with minimal differentiation (M1)

  • AML without maturation (M2)

  • AML with maturation (M2)

  • Acute myelomonocytic leukemia (M3)

  • Acute monoblastic/monocytic leukemia (M4)

  • Acute erythroid leukemia (M5)

  • Pure erythroid leukemia (M6)

  • Erythroleukemia, erythroid/myeloid (M6)

  • Acute megakaryoblastic leukemia (M7)

  • Acute basophilic leukemia

  • Acute panmyelosis with myelofibrosis

Myeloid sarcoma

Myeloid proliferations related to Down syndrome:

  • Transient abnormal myelopoiesis

  • Myeloid leukemia associated with Down syndrome

Blastic plasmacytoid dendritic cell neoplasm