Mu Heavy Chain Disease Follow-up

Updated: Oct 13, 2017
  • Author: Jessica Katz, MD, PhD, FACP; Chief Editor: Emmanuel C Besa, MD  more...
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Further Outpatient Care

Once the diagnosis of mu heavy chain disease (mu-HCD) is established, any accompanying lymphoproliferative disorder should be treated. Typically, this involves chemotherapy administered in an outpatient setting.

If no overt lymphoproliferative disorder is found, the patient should be evaluated every few months to assess the abnormal protein. Reasonable follow-up intervals are every 3 months in the first year following diagnosis, every 4 months for the next year, and every 6 months thereafter. The patient should be evaluated earlier if symptoms occur. If the patient is symptomatic in any way, then radiologic assessment and other diagnostic procedures for lymphoproliferative disorders are essential.



See the list below:

  • Possible complications include pathologic fracture secondary to osteolytic lesions.

  • Renal insufficiency occasionally is associated with mu-HCD. Etiologies include cast glomerulopathy, nodular glomerulosclerosis, and amyloidosis.

  • Cytopenias requiring transfusion are possible in advanced disease.