Systems for staging diffuse large B-cell lymphoma (DLBCL) are provided below, including the World Health Organization (WHO) classification[1, 2] and the Cotswolds modification of the Ann Arbor system. Risk stratification with the International Prognostic Index (IPI) score is also provided.[3]
DLBCL, not otherwise specified (NOS) includes the following:
Other forms include the following:
Table. Cotswolds modification of Ann Arbor staging system (Open Table in a new window)
Stage |
Area of Involvement |
I |
Single lymph node group |
II |
Multiple lymph node groups on same side of diaphragm |
II |
Multiple lymph node groups on both sides of diaphragm |
IV |
Multiple extranodal sites or lymph nodes and extranodal disease |
X |
Bulk > 10 cm |
E |
Extranodal extension or single isolated site of extranodal disease |
A/B |
B symptoms: weight loss > 10%, fever, drenching night sweats |
Factors (1 point for each factor present):
Risk category (factors):
See also the following calculators: