Hemolytic-Uremic Syndrome Questions & Answers

Updated: Dec 13, 2018
  • Author: Malvinder S Parmar, MBBS, MS, FRCPC, FACP, FASN; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Questions & Answers

Overview

What is hemolytic-uremic syndrome (HUS)?

When was hemolytic-uremic syndrome (HUS) first described?

What is the pathogenesis of atypical (non-Stx-associated) hemolytic-uremic syndrome (HUS)?

What is the pathogenesis of familial non-Stx-associated hemolytic-uremic syndrome (HUS)?

What is the primary event in the pathogenesis of hemolytic-uremic syndrome (HUS)?

How is hemolytic-uremic syndrome (HUS) categorized?

What is the pathogenesis of typical (Stx-associated) hemolytic-uremic syndrome (HUS)?

What are triggers for sporadic non-Stx-associated hemolytic-uremic syndrome (HUS)?

Which patient group is at highest risk for hemolytic-uremic syndrome (HUS)?

Which bacterial infections cause hemolytic-uremic syndrome (HUS)?

Which viral infections cause hemolytic-uremic syndrome (HUS)?

Which fungal infection causes hemolytic-uremic syndrome (HUS)?

Which vaccines may cause hemolytic-uremic syndrome (HUS)?

What causes secondary or sporadic hemolytic-uremic syndrome (HUS)?

How does pregnancy-associated hemolytic-uremic syndrome (HUS) develop?

Which drugs are implicated in the etiology of non-Stx-hemolytic-uremic syndrome (HUS)?

What is the prevalence of hemolytic-uremic syndrome (HUS) following transplantation?

How prevalent is hemolytic-uremic syndrome (HUS) in the US?

How prevalent is hemolytic-uremic syndrome (HUS) globally?

How prevalent is hemolytic-uremic syndrome (HUS) by race and sex?

How prevalent is hemolytic-uremic syndrome (HUS) by age?

What are possible complications of hemolytic-uremic syndrome (HUS)?

What is the prevalence of neurological complications of hemolytic-uremic syndrome (HUS)?

What is the prognosis of Stx-hemolytic-uremic syndrome (HUS)?

What is the prognosis of non Stx-hemolytic-uremic syndrome (HUS)?

Which factors predict a poor prognosis for hemolytic-uremic syndrome (HUS)?

How does kidney transplant affect the prognosis of hemolytic-uremic syndrome (HUS)?

What information should be given to patients with hemolytic-uremic syndrome (HUS)?

Presentation

What are the signs and symptoms of hemolytic-uremic syndrome (HUS)?

Which physical findings suggest hemolytic-uremic syndrome (HUS)?

DDX

Which conditions should be included in the differential diagnoses of hemolytic-uremic syndrome (HUS)?

What are the differential diagnoses for Hemolytic-Uremic Syndrome?

Workup

What is the role of lab studies in the diagnosis of hemolytic-uremic syndrome (HUS)?

What is the role of imaging studies in the diagnosis of hemolytic-uremic syndrome (HUS)?

What is the role of biopsy in the diagnosis of hemolytic-uremic syndrome (HUS)?

What are characteristic pathologic findings of hemolytic-uremic syndrome (HUS)?

Treatment

How are the treatment options for Stx-hemolytic-uremic syndrome (HUS)?

What is the role of plasma exchange in the treatment of non-Stx-hemolytic-uremic syndrome (HUS)?

What is the role of eculizumab in the treatment of hemolytic-uremic syndrome (HUS)?

What is the role of renal transplantation in the treatment of hemolytic-uremic syndrome (HUS)?

What is included in supportive therapy for hemolytic-uremic syndrome (HUS)?

Which specialists should be consulted in the treatment of hemolytic-uremic syndrome (HUS)?

What dietary restrictions are needed during treatment of hemolytic-uremic syndrome (HUS)?

Medications

Which medications are used in the treatment of hemolytic-uremic syndrome (HUS)?

Which medications in the drug class Monoclonal Antibodies are used in the treatment of Hemolytic-Uremic Syndrome?

Follow-up

How should patients be monitored following treatment of hemolytic-uremic syndrome (HUS)?

What is included in inpatient care for hemolytic-uremic syndrome (HUS)?

When is transfer to a tertiary care facility indicated for treatment of hemolytic-uremic syndrome (HUS)?

How is hemolytic-uremic syndrome (HUS) prevented?