Hodgkin Lymphoma Questions & Answers

Updated: Sep 12, 2018
  • Author: Bradley W Lash, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Questions & Answers

Overview

What is the WHO classification of Hodgkin lymphoma (Hodgkin disease)?

What are the signs and symptoms of Hodgkin lymphoma (Hodgkin disease)?

Which lab tests are used in the diagnosis of Hodgkin lymphoma (Hodgkin disease)?

Which imaging studies are used in in the diagnosis of Hodgkin lymphoma (Hodgkin disease)?

What is the role of histology in the diagnosis of Hodgkin lymphoma (Hodgkin disease)?

What is the Ann Arbor classification for stages of Hodgkin lymphoma (Hodgkin disease)?

What are general treatment principles for Hodgkin lymphoma (Hodgkin disease)?

How are the radiation fields used in the treatment of Hodgkin lymphoma (Hodgkin disease) defined?

What are the induction chemotherapy regimens used to treat Hodgkin lymphoma (Hodgkin disease)?

What are salvage chemotherapy regimens used for Hodgkin lymphoma (Hodgkin disease)?

What are the possible toxicities from treatment of Hodgkin lymphoma (Hodgkin disease)?

What is Hodgkin lymphoma (Hodgkin disease)?

What is required for the diagnosis of Hodgkin lymphoma (Hodgkin disease)?

How is Hodgkin lymphoma (Hodgkin disease) treated?

What are the five types of Hodgkin lymphoma (Hodgkin disease)?

What is the pathogenesis of classical Hodgkin lymphoma (Hodgkin disease)?

What are the four types of classical Hodgkin lymphoma (Hodgkin disease)?

What is nodular sclerosing Hodgkin lymphoma (NSHL)?

What is mixed-cellularity Hodgkin lymphoma (MCHL)?

What is lymphocyte depleted Hodgkin lymphoma (LDHL)?

What is lymphocyte-rich Hodgkin lymphoma (LRHL)?

What is nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL)?

What is the role of Epstein-Barr virus (EBV) in the etiology of Hodgkin lymphoma (Hodgkin disease)?

What is the role of genetics in the etiology of Hodgkin lymphoma (Hodgkin disease)?

Which genetic factors may increase the risk of developing nodular sclerosing Hodgkin lymphoma (Hodgkin disease) (NSHL)?

What is the incidence of Hodgkin lymphoma (Hodgkin disease) in the US?

What is the global incidence of Hodgkin lymphoma (Hodgkin disease)?

How does the incidence of Hodgkin lymphoma (Hodgkin disease) vary by sex and race?

How does the incidence of Hodgkin lymphoma (Hodgkin disease) vary by age?

What is prognosis of Hodgkin lymphoma (Hodgkin disease)?

What is the International Prognostic System (IPS) for Hodgkin lymphoma (Hodgkin disease)?

What education about Hodgkin lymphoma (Hodgkin disease) should patients receive?

What self-exams should be performed by female patients treated for Hodgkin lymphoma (Hodgkin disease)?

What education should patients with Hodgkin lymphoma (Hodgkin disease) receive following splenectomy?

Which specialist consultations may be helpful for patients who survive Hodgkin lymphoma (Hodgkin disease)?

Presentation

What are the signs and symptoms of Hodgkin lymphoma (Hodgkin disease)?

Which physical findings suggest Hodgkin lymphoma (Hodgkin disease)?

DDX

Which conditions should be considered in the differential diagnoses of Hodgkin lymphoma (Hodgkin disease)?

Which factors may lead to a delay in the diagnosis of Hodgkin lymphoma (Hodgkin disease)?

How is Hodgkin lymphoma (Hodgkin disease) differentiated from hemophagocytic syndrome?

What are the differential diagnoses for Hodgkin Lymphoma?

Workup

What is the standard approach to the workup of Hodgkin lymphoma (Hodgkin disease)?

What is the role of lab testing in the evaluation of Hodgkin lymphoma (Hodgkin disease)?

What is the role of imaging studies in the evaluation of Hodgkin lymphoma (Hodgkin disease)?

What is the role of CT scanning in the diagnosis of Hodgkin lymphoma (Hodgkin disease)?

What is the role of PET scanning in the staging of Hodgkin lymphoma (Hodgkin disease)?

How is the diagnosis of Hodgkin lymphoma (Hodgkin disease) confirmed?

What is the role of bone marrow biopsy in the evaluation of Hodgkin lymphoma (Hodgkin disease)?

What is the role of thoracentesis in the evaluation of Hodgkin lymphoma (Hodgkin disease)?

Which tests are performed if CNS symptoms are present in Hodgkin lymphoma (Hodgkin disease)?

How is Hodgkin lymphoma (Hodgkin disease) staged?

What do A and B designations for Hodgkin lymphoma (Hodgkin disease) denote?

How does Hodgkin lymphoma (Hodgkin disease) spread?

Treatment

What are the treatment options for Hodgkin lymphoma (Hodgkin disease)?

How does the definition of early-stage favorable Hodgkin lymphoma (Hodgkin disease) differ among guidelines?

What are possible short-term toxicities of Hodgkin lymphoma (Hodgkin disease) treatment?

What are possible long-term toxicities of Hodgkin lymphoma (Hodgkin disease) treatment?

What are goals of Hodgkin lymphoma (Hodgkin disease) treatment?

Which specialist consultations are needed for the management of Hodgkin lymphoma (Hodgkin disease)?

What is the cure rate of Hodgkin lymphoma (Hodgkin disease)?

How are treatment response criteria defined for Hodgkin lymphoma (Hodgkin disease)?

What is the primary goal of Hodgkin lymphoma (Hodgkin disease) treatment?

How is therapeutic response assessed in Hodgkin lymphoma (Hodgkin disease)?

What is the role of radiation therapy in Hodgkin lymphoma (Hodgkin disease)?

How are the radiation fields used to treat Hodgkin lymphoma (Hodgkin disease) defined?

What is the standard dose of radiation used for treatment of Hodgkin lymphoma (Hodgkin disease)?

Which induction chemotherapy regimens are used for treatment of Hodgkin lymphoma (Hodgkin disease)?

When is the MOPP regimen indicated for treatment of Hodgkin lymphoma (Hodgkin disease)?

How are the ABVD and A+AVD regimens used in the treatment of Hodgkin lymphoma (Hodgkin disease)?

What is the Stanford V regimen for treatment of Hodgkin lymphoma (Hodgkin disease)?

What is the BEACOPP regimen for treatment of Hodgkin lymphoma (Hodgkin disease)?

How is the MOPP regimen administered in Hodgkin lymphoma (Hodgkin disease)?

How are the ABVD and A+AVD regimens administered in Hodgkin lymphoma (Hodgkin disease)?

How is the Stanford V regimen administered in Hodgkin lymphoma (Hodgkin disease)?

How is the BEACOPP regimen administered in Hodgkin lymphoma (Hodgkin disease)?

What are the commonly used salvage regimens for Hodgkin lymphoma (Hodgkin disease)?

How is the ICE regimen administered in Hodgkin lymphoma (Hodgkin disease)?

How is the DHAP regimen administered in Hodgkin lymphoma (Hodgkin disease)?

What is the role of hematopoietic stem cell transplantation in the treatment of Hodgkin lymphoma (Hodgkin disease)?

What is the BEAM regimen for Hodgkin lymphoma (Hodgkin disease)?

What is early-stage, low risk Hodgkin lymphoma (Hodgkin disease)?

What are the treatment options for early-stage, low risk Hodgkin lymphoma (Hodgkin disease)?

What are NCCN treatment guidelines for early-stage, low risk Hodgkin lymphoma (Hodgkin disease)?

What is the role of radiation therapy in the treatment of early-stage, low risk Hodgkin lymphoma (Hodgkin disease)?

What is the role of imaging studies in the treatment of early-stage, low risk Hodgkin lymphoma (Hodgkin disease)?

What is early-stage, unfavorable Hodgkin lymphoma (Hodgkin disease)?

What treatment regimens are used for early-stage, unfavorable Hodgkin lymphoma (Hodgkin disease)?

What are the treatment options for Hodgkin lymphoma (Hodgkin disease) with bulky mediastinal disease?

What are NCCN treatment guidelines for early-stage, unfavorable Hodgkin lymphoma (Hodgkin disease)?

What is the NCCN recommendation for use of PET scanning in the treatment of early-stage, unfavorable Hodgkin lymphoma (Hodgkin disease)?

What is advanced Hodgkin lymphoma (Hodgkin disease)?

What are the commonly used chemotherapy regimen for advanced Hodgkin lymphoma (Hodgkin disease)?

What is the role of GCSF in the treatment of Hodgkin lymphoma (Hodgkin disease)?

How effective is ABVD in treating advanced Hodgkin lymphoma (Hodgkin disease)?

What is the role of the BEACOPP regimen in the treatment of advanced Hodgkin lymphoma (Hodgkin disease)?

When is the Stanford V regimen used in treatment of advanced Hodgkin lymphoma (Hodgkin disease)?

What is the role of radiation for treatment of advanced Hodgkin lymphoma (Hodgkin disease)?

What is the role of PET scanning in the treatment of advanced Hodgkin lymphoma (Hodgkin disease)?

What are the treatment options for advanced Hodgkin lymphoma (Hodgkin disease) with and without bulky disease?

How is early-stage NLPHL treated?

What may improve treatment outcome in patients with HIV and advanced Hodgkin lymphoma (Hodgkin disease)?

What is the treatment for relapsed Hodgkin lymphoma (Hodgkin disease)?

What remains unknown about salvage and HDC therapy for Hodgkin lymphoma (Hodgkin disease)?

What is the role of allogeneic stem cell transplantation in the treatment of Hodgkin lymphoma (Hodgkin disease)?

What is the role of brentuximab vedotin in the treatment of Hodgkin lymphoma (Hodgkin disease)?

What is the role of nivolumab in the treatment of Hodgkin lymphoma (Hodgkin disease)?

What is the role of pembrolizumab in the treatment of Hodgkin lymphoma (Hodgkin disease)?

What are the risk factors for cardiac complication of Hodgkin lymphoma (Hodgkin disease) therapy?

What are the risk factors for pulmonary complications of Hodgkin lymphoma (Hodgkin disease) therapy?

Which secondary cancers are possible complications of Hodgkin lymphoma (Hodgkin disease) therapy?

What is the prevalence of infertility following treatment for Hodgkin lymphoma (Hodgkin disease)?

What are the possible complications of splenectomy for treatment of Hodgkin lymphoma (Hodgkin disease)?

What noninfectious complications may occur following successful treatment of Hodgkin lymphoma (Hodgkin disease)?

What are the NCCN and ESMO guidelines for long-term follow-up following complete remission of Hodgkin lymphoma?

What should follow-up exams for Hodgkin lymphoma (Hodgkin disease) include?

After five years, what is the NCCN recommended surveillance schedule for Hodgkin lymphoma (Hodgkin disease)?

What is the role of PET scanning following complete remission (CR) of Hodgkin lymphoma (Hodgkin disease)?

What monitoring is needed following ABVD treatment of Hodgkin lymphoma (Hodgkin disease)?

What are goals for survivor care of Hodgkin lymphoma (Hodgkin disease)?

Guidelines

What is required for diagnosis of Hodgkin lymphoma (Hodgkin disease)?

What are biopsy recommendations for Hodgkin lymphoma (Hodgkin disease)?

Which symptoms may aid in the diagnosis of Hodgkin lymphoma (Hodgkin disease)?

Which classification system is used for Hodgkin lymphoma (Hodgkin disease) staging?

What are the ESMO guidelines for staging and risk assessment of Hodgkin lymphoma (Hodgkin disease)?

What are the International Conference on Malignant Lymphomas guidelines for the staging of Hodgkin lymphoma (Hodgkin disease)?

What are the risk groups for Hodgkin lymphoma (Hodgkin disease)?

What are the NCCN guidelines for determining unfavorable factors for stage I-II Hodgkin lymphoma (Hodgkin disease)?

How is the International Prognostic Score (IPS) for Hodgkin lymphoma (Hodgkin disease) calculated?

How is primary treatment of Hodgkin lymphoma (Hodgkin disease) determined?

What are NCCN recommendations for treatment of early-stage favorable Hodgkin lymphoma (Hodgkin disease)?

What are NCCN recommendations for treatment of early-stage unfavorable Hodgkin lymphoma (Hodgkin disease)?

What are NCCN recommendations for the treatment of advanced Hodgkin lymphoma (Hodgkin disease)?

What are NCCN recommendations for treatment of refractory or relapsed Hodgkin lymphoma (Hodgkin disease)?

What are the NCCN recommendations for treatment of NLPHL?

What are NCCN recommendations for long-term monitoring of Hodgkin lymphoma (Hodgkin disease)?

What are NCCN initial follow-up exam recommendations following complete remission of Hodgkin lymphoma (Hodgkin disease)?

What are the NCCN five-year follow up exam recommendations following complete remission of Hodgkin lymphoma (Hodgkin disease)?

Medications

Which medications are used in the treatment of Hodgkin lymphoma (Hodgkin disease)?

What is the basis for cyclic dosage of chemotherapy for Hodgkin lymphoma (Hodgkin disease)?

Which medications in the drug class Corticosteroids are used in the treatment of Hodgkin Lymphoma?

Which medications in the drug class PD-1/PD-L1 Inhibitors are used in the treatment of Hodgkin Lymphoma?

Which medications in the drug class Antineoplastics, Antimicrotubular are used in the treatment of Hodgkin Lymphoma?

Which medications in the drug class Antineoplastics, Anthracyclines are used in the treatment of Hodgkin Lymphoma?

Which medications in the drug class Immunosuppressants; Antineoplastics, Antimetabolite; DMARDs, Immunomodulators are used in the treatment of Hodgkin Lymphoma?

Which medications in the drug class Antineoplastics, Alkylating, DMARDs, Immunomodulators are used in the treatment of Hodgkin Lymphoma?

Which medications in the drug class Antineoplastics, Podophyllotoxin Derivatives are used in the treatment of Hodgkin Lymphoma?

Which medications in the drug class Antineoplastics, Vinca Alkaloid are used in the treatment of Hodgkin Lymphoma?

Which medications in the drug class Antineoplastics, Antibiotic are used in the treatment of Hodgkin Lymphoma?

Which medications in the drug class Antineoplastics, Alkylating are used in the treatment of Hodgkin Lymphoma?