Light-Chain Deposition Disease Clinical Presentation

Updated: Oct 26, 2021
  • Author: Eric J Vick, MD, PhD; Chief Editor: Emmanuel C Besa, MD  more...
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Patients are typically found to have light-chain deposition disease (LCDD) when they are evaluated for proteinuria or nephrotic syndrome by kidney biopsy and may have simultaneous dysfunction of other organs, though rarely. The common symptoms and signs are related to associated organ involvement and may manifest as kidney failure, congestive heart failure, and/or liver failure. Most patients present with advanced disease, owing to a delay in the diagnosis and insidious onset of dysfunction.



Light-chain deposition disease (LCDD) patients may present with end-organ damage, which chiefly manifests as hypertension, peripheral edema, neuropathy, or congestive heart failure. Approximately 50% of patients with LCDD present with nephrotic syndrome. However, in a quarter of patients, the proteinuria is less than 1 g/day as a result of tubulointerstitial involvement. Rare findings on physical examination include new heart sounds and splenomegaly.