Light-Chain Deposition Disease Follow-up

Updated: Oct 26, 2021
  • Author: Eric J Vick, MD, PhD; Chief Editor: Emmanuel C Besa, MD  more...
  • Print


Median survival for patients with light-chain deposition disease (LCDD) is about 4 years. The largest series published so far has reported after a median follow-up of 27 months; 57% of patients developed uremia and 59% of patients died. [10] The prognostic factors are age, associated multiple myeloma, and extrarenal light-chain deposition. [5, 19] The presence of end-stage renal disease (ESRD) and need for dialysis did not change the outcome for these patients.

Overall survival has been shown to be influenced by patient age, the presence of coexisting multiple myeloma or cast nephropathy, and any evidence of extrarenal light-chain deposition.

The natural or treated history of LCDD is difficult to determine, as this disease is uncommon.