Light-Chain Deposition Disease Questions & Answers

Updated: Sep 26, 2019
  • Author: Swapna Boppana, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Questions & Answers

Overview

What is light-chain deposition disease (LCDD)?

What is the pathophysiology of light-chain deposition disease (LCDD)?

What is the pathophysiology of extrarenal light-chain deposition disease (LCDD)?

What is the prevalence of light-chain deposition disease (LCDD)?

What is the morbidity and mortality associated with light-chain deposition disease (LCDD)?

Presentation

Which clinical history findings are characteristic of light-chain deposition disease (LCDD)?

Which physical findings are characteristic of light-chain deposition disease (LCDD)?

What causes light-chain deposition disease (LCDD)?

DDX

What are the differential diagnoses for Light-Chain Deposition Disease?

Workup

What is the role of lab tests in the workup of light-chain deposition disease (LCDD)?

What is the role of imaging studies in the workup of light-chain deposition disease (LCDD)?

What is the role of biopsy in the workup of light-chain deposition disease (LCDD)?

Which histologic findings are characteristic of light-chain deposition disease (LCDD)?

Treatment

How is light-chain deposition disease (LCDD) treated?

What is the role of autologous stem cell transplantation in the treatment of light-chain deposition disease (LCDD)?

What is the role of bortezomib in the treatment of light-chain deposition disease (LCDD)?

What is the role of immunomodulatory drugs in the treatment of light-chain deposition disease (LCDD)?

What is the role of renal transplantation in the treatment of light-chain deposition disease (LCDD)?

Follow-up

What is the prognosis of light-chain deposition disease (LCDD)?