B-Cell Lymphoma Differential Diagnoses

Updated: Mar 31, 2023
  • Author: Mohammad Muhsin Chisti, MD, FACP; Chief Editor: Emmanuel C Besa, MD  more...
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Diagnostic Considerations

Other problems to be considered include the following:

  • Pseudolymphoma syndrome
  • Carcinoma of unknown primary, especially in patients who present with significant lymphadenopathy in the mediastinum or abdomen.
  • Mycobacterial infections, especially in patients with immune compromise; may manifest as fever, weight loss, and lymphadenopathy and, therefore, clinically mimic lymphoma.
  • Fungal infections (eg, histoplasmosis, cryptococcosis in the acute phase) can similarly manifest as lymphadenopathy, fever, and (occasionally) weight loss, simulating lymphoma.

Differential Diagnoses