B-Cell Lymphoma Questions & Answers

Updated: Apr 09, 2020
  • Author: Mohammad Muhsin Chisti, MD, FACP; Chief Editor: Emmanuel C Besa, MD  more...
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Questions & Answers

Overview

What is B-cell lymphoma?

What is the difference between non-Hodgkin lymphoma and Hodgkin lymphoma?

What are the prognostic differences between indolent and aggressive B-cell lymphomas?

What is the survival rate of NHL/B-cell lymphoma?

How is complete remission achieved in aggressive forms of NHL/B-cell lymphoma?

What are B-cell and T/natural killer (NK)-cell neoplasms?

What are the WHO categories of B-cell malignancies in B-cell lymphoma?

What is the WHO classification of mature B-cell neoplasms in B-cell lymphoma?

What are the etiologic factors in B-cell lymphoma?

What is the pathogenesis of B-cell lymphoma?

What is the most common chromosomal abnormality in NHL/B-cell lymphoma?

Which tests are indicated in the workup of B-cell lymphoma of germinal center origin?

Which occupations are associated with a high risk of NHL/B-cell lymphoma?

Which chemicals have been linked to NHL/B-cell lymphoma?

Which cancer treatments are associated with an increased risk for NHL/B-cell lymphoma?

Which viruses are linked to the pathogenesis of NHL/B-cell lymphoma?

Which immunodeficiencies are associated with an increased risk of NHL/B-cell lymphoma?

Which connective-tissue disorders are associated with an increased risk of NHL/B-cell lymphoma?

Which GI conditions predispose patients to developing NHL/B-cell lymphoma?

What is the mortality rate of NHL/B-cell lymphoma in the US?

What is the risk of NHL/B-cell lymphoma in the US?

How does the epidemiology of NHL/B-cell lymphoma differ between developing countries and developed countries?

What are the most common types of B-cell lymphoma in developing countries?

How common is NHL/B-cell lymphoma in Europe?

What endemic factors are associated with NHL/B-cell lymphoma?

Which condition is associated with NHL/B-cell lymphoma in individuals of Mediterranean ethnicity?

What is the geographic distribution of follicular NHL/B-cell lymphoma?

What is the age-related incidence of NHL/B-cell lymphoma?

Is NHL/B-cell lymphoma more common in men or women?

Does NHL/B-cell lymphoma have a racial predilection?

What are the prognostic factors of NHL/B-cell lymphoma?

What is the role of the International Prognostic Index (IPI) in the prognosis of NHL/B-cell lymphoma?

Which risk factors for NHL/B-cell lymphoma are included in the International Prognostic Index (IPI)?

What are the prognostic risk categories for NHL/B-cell lymphoma in the International Prognostic Index (IPI)?

What are the 5-year survival rates for NHL/B-cell lymphoma according to the International Prognostic Index (IPI)?

Presentation

What is the most common manifestation of B-cell lymphoma?

Which systemic symptoms are poor prognostic factors for B-cell lymphoma?

Which organ-specific symptoms are associated with specific sites of involvement of B-cell lymphoma?

What are the typical physical exam findings of B-cell lymphoma?

Which physical findings are associated with advanced high-grade B-cell lymphoma?

Which findings suggest additional workup is indicated in patients with B-cell lymphoma?

DDX

What are the diagnostic considerations of NHL/B-cell lymphoma?

What are the differential diagnoses for B-Cell Lymphoma?

Workup

What are the approach considerations in the workup of NHL/B-cell lymphoma?

Which procedure is preferred for the initial diagnosis of NHL/B-cell lymphoma?

Which studies are indicated to confirm a diagnosis of NHL/B-cell lymphoma?

Which lab studies are indicated in the workup of NHL/B-cell lymphoma?

What is the role of an immunoglobulin (Ig) gene rearrangement in the workup of NHL/B-cell lymphoma?

How is polymerase chain reaction (PCR) used in the workup of NHL/B-cell lymphoma?

What is the role of polymerase chain reaction (PCR) in the workup of NHL/B-cell lymphoma?

What are the preferred imaging studies for staging NHL/B-cell lymphoma?

Which nodal lymphoma histologies are indicated in the workup of NHL/B-cell lymphoma?

What is the role of PET/CT scanning in the workup of B-cell lymphoma?

What is the role of contrast-enhanced CT scanning in the workup of NHL/B-cell lymphoma?

When is evaluation of specific sites indicated in the workup of NHL/B-cell lymphoma?

How is follicular lymphoma characterized in the histologic findings of NHL/B-cell lymphoma?

How is Burkitt lymphoma characterized in the histologic findings of NHL/B-cell lymphoma?

What are the histologic findings of NHL/B-cell lymphoma?

How is chronic lymphocytic leukemia (CLL)/small lymphocytic leukemia (SLL) characterized in the histologic findings of NHL/B-cell lymphoma?

How is mucosa-associated lymphoid tissue (MALT) lymphoma characterized in the histologic findings of NHL/B-cell lymphoma?

How is nodal marginal zone lymphoma (NMZL) characterized in the histologic findings of NHL/B-cell lymphoma?

How is diffuse large B-cell lymphoma (DLBCL) characterized in the histologic findings of follicular lymphoma?

How is mantle cell lymphoma characterized in the histologic findings of B-cell lymphoma?

What are the common morphologic features of diffuse large B-cell lymphoma (DLBCL)?

What are the histologic findings in diffuse large B-cell lymphoma (DLBCL)?

What are the immunophenotypic subdivisions of diffuse large B-cell lymphoma (DLBCL)?

How is diffuse large B-cell lymphoma (DLBCL) classified?

What are the subtypes of diffuse large B-cell lymphoma (DLBCL)?

What are the types of large B-cell lymphoma?

What is primary mediastinal (thymic) large B-cell lymphoma?

What is the role of flow cytometry analysis in the workup of NHL/B-cell lymphoma?

How does the Ann Arbor staging system classify NHL/B-cell lymphoma?

How does the Lugano classification stage NHL/B-cell lymphoma?

What other factors have important prognostic value in B-cell NHL?

How is the International Prognostic Index (IPI) used in NHL/B-cell lymphoma?

Treatment

What are the approach considerations in the treatment of NHL/B-cell lymphoma?

What complications are associated with treatment for NHL/B-cell lymphoma?

Which specialist consultations are indicated in the treatment of NHL/B-cell lymphoma?

When is transfer indicated for patients with NHL/B-cell lymphoma?

What are the dietary recommendations for patients with NHL/B-cell lymphoma?

Guidelines

What are the staging guidelines for NHL/B-cell lymphoma?

What is the role of the International Prognostic Index (IPI) in low grade B-cell lymphoma?

Which risk factors are included in the International Prognostic Index (IPI) in the prognosis of NHL/B-cell lymphoma?

What are the risk categories of NHL/B-cell lymphoma in the International Prognostic Index (IPI) score?

What are the survival rates of NHL/B-cell lymphoma based on the International Prognostic Index (IPI) score?

What is the WHO classification for grading NHL/B-cell follicular lymphoma (FL)?

What do the NCCN guidelines note about the treatment of grade 3 follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL)?

How is primary cutaneous follicle center lymphoma (PCFCL) classified in the WHO guidelines on NHL/B-cell follicular lymphoma?

Which studies does the NCCN recommend for the diagnosis of B-cell follicular lymphoma (FL)?

What are the GELF criteria for immediate therapy in NHL/B-cell follicular lymphoma?

What are the FLIPI risk stratification factors for NHL/B-cell follicular lymphoma?

What are the FLIPI2 risk stratification factors for NHL/B-cell follicular lymphoma?

What are the NCCN guidelines on first-line therapy in the treatment of NHL/B-cell follicular lymphoma?

What are the first-line regimens for consolidation or extended dosing in the treatment of B-cell follicular lymphoma?

What are the preferred regimens for second-line and subsequent therapy in the treatment of B-cell follicular lymphoma?

What are the options for second-line consolidation or extended dosing in the treatment of B-cell follicular lymphoma?

What are B-cell mucosa-associated lymphoid tissue (MALT) lymphomas?

What causes B-cell gastric MALT lymphomas?

What is the preferred treatment for B-cell non-gastric MALT lymphomas?

How are B-cell gastric MALT lymphomas treated?

How is B-cell mantle cell lymphoma (MCL) diagnosed?

What is the risk stratification for B-cell mantle cell lymphoma (MCL)?

What are the MIPI categories for risk stratification in B-cell mantle cell lymphoma (MCL)?

What is the role of the Ki-67 proliferative assay in in the workup of B-cell mantle cell lymphomas (MCL)?

What are the treatment recommendations for B-cell mantle cell lymphoma (MCL)?

What are the induction therapy regimens for the treatment of B-cell mantle cell lymphoma (MCL)?

What is the CALGB regimen for the treatment of B-cell mantle cell lymphoma (MCL)?

What are the less aggressive regimens for the treatment of B-cell mantle cell lymphoma (MCL)?

What is consolidation therapy for the treatment of B-cell mantle cell lymphoma (MCL)?

What are the second-line therapy regimens for the treatment of B-cell mantle cell lymphoma (MCL)?

Which studies are recommended by the NCCN to establish a diagnosis of diffuse large B-cell lymphoma (DLBCL)?

What are the IPI risk factors for diffuse large B-cell lymphoma (DLBCL)?

What are the IPI risk categories for diffuse large B-cell lymphoma (DLBCL)?

What are the Ann Arbor IPI risk factors for diffuse large B-cell lymphoma (DLBCL)?

What are the Ann Arbor IPI risk categories for diffuse large B-cell lymphoma (DLBCL)?

What is the first-line therapy for the treatment of diffuse large B-cell lymphoma (DLBCL)?

What is the first-line therapy for the treatment of diffuse large B-cell lymphoma (DLBCL) in patients who have poor left ventricular functions or are very frail?

Which treatment regimens for diffuse large B-cell lymphoma (DLBCL) are indicated in elderly patients with comorbidities?

What are the first-line consolidation/optional treatment regimens for diffuse large B-cell lymphoma (DLBCL)?

What are the treatment regimens for diffuse large B-cell lymphoma (DLBCL) with concurrent CNS disease?

What are the second-line and subsequent treatment regimens for diffuse large B-cell lymphoma (DLBCL)?

What are the second-line and subsequent treatment regimens for diffuse large B-cell lymphoma (DLBCL) in patients who are not candidates for high-dose therapy?

What is the follow-up for patients with diffuse large B-cell lymphoma (DLBCL) who are in complete remission?

How does WHO classify the clinical variants of B-cell Burkitt lymphoma (BL)?

Which studies are recommended to establish a diagnosis of B-cell Burkitt lymphoma (BL)?

What are the SEER risk factors for B-cell Burkitt lymphoma (BL)?

What are the SEER risk groups for B-cell Burkitt lymphoma (BL)?

What are the SEER 5-year survival rates for B-cell Burkitt lymphoma (BL)?

What induction and second-line therapy regimens are used in the treatment of Burkitt lymphoma?

What are the NCCN recommendations for follow-up in patients with B-cell Burkitt lymphoma?

Which organizations have issued treatment guidelines for cutaneous B-cell lymphomas (CBCL)?

What are the main types of cutaneous B-cell lymphomas (CBCL)?

Which studies are recommended to establish a diagnosis of cutaneous B-cell lymphoma (CBCL)?

What are the TNM staging classifications for cutaneous B-cell lymphomas (CBCL)?

What is the recommended treatment for cutaneous B-cell lymphomas (CBCL)?

Medications

What are the goals of drug treatment for B-cell lymphoma?

Which medications in the drug class PD-1/PD-L1 Inhibitors are used in the treatment of B-Cell Lymphoma?

Which medications in the drug class Antineoplastics, Angiogenesis inhibitor are used in the treatment of B-Cell Lymphoma?

Which medications in the drug class Antineoplastics, PI3K Delta Inhibitors are used in the treatment of B-Cell Lymphoma?

Which medications in the drug class Antineoplastics, Tyrosine Kinase Inhibitor are used in the treatment of B-Cell Lymphoma?

Which medications in the drug class Antineoplastic Agents are used in the treatment of B-Cell Lymphoma?

Which medications in the drug class Corticosteroids are used in the treatment of B-Cell Lymphoma?

Which medications in the drug class Monoclonal Antibodies are used in the treatment of B-Cell Lymphoma?

Which medications in the drug class Hematopoietic Growth Factors are used in the treatment of B-Cell Lymphoma?

Which medications in the drug class CAR T cell Therapy are used in the treatment of B-Cell Lymphoma?