Diffuse Large Cell Lymphoma Questions & Answers

Updated: Jun 12, 2019
  • Author: Shipra Gandhi, MBBS; Chief Editor: Emmanuel C Besa, MD  more...
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Questions & Answers

Overview

How common is diffuse large cell lymphoma?

What are the signs and symptoms of diffuse large cell lymphoma?

How is diffuse large cell lymphoma diagnosed?

Which chemotherapy regimens are used in the treatment of diffuse large cell lymphoma?

What is diffuse large cell lymphoma?

How is diffuse large cell lymphoma classified?

How are the symptoms of diffuse large cell lymphoma classified?

What causes diffuse large cell lymphoma?

Which conditions are associated with diffuse large cell lymphoma?

What is the prevalence of diffuse large cell lymphoma in the US?

What is the global prevalence of diffuse large cell lymphoma?

What are the racial predilections of diffuse large cell lymphoma?

What are the sexual predilections of diffuse large cell lymphoma?

Which age groups have the highest prevalence of diffuse large cell lymphoma?

What is the prognosis of diffuse large cell lymphoma?

How is the risk stratification for diffuse large cell lymphoma determined?

What are the prognostic factors in early stage diffuse large cell lymphoma?

What are the prognostic factors in advanced stage diffuse large cell lymphoma?

What is tumor lysis syndrome in diffuse large cell lymphoma and how is it prevented?

How is uric acid nephropathy prevented in diffuse large cell lymphoma?

How are neutropenic fevers and sepsis prevented in diffuse large cell lymphoma?

What are the chemotherapy-related complications in diffuse large cell lymphoma?

What is included in patient education about diffuse large cell lymphoma?

Presentation

Which clinical history findings are characteristic of diffuse large cell lymphoma?

What is the focus of the clinical history for suspected diffuse large cell lymphoma?

Which physical findings are characteristic of diffuse large cell lymphoma?

What is included in the physical exam to evaluate suspected diffuse large cell lymphoma?

DDX

Which conditions should be included in the differential diagnoses of diffuse large cell lymphoma?

Workup

What is included in the initial evaluation of diffuse large cell lymphoma?

What is the role of CBC count in the workup of diffuse large cell lymphoma?

What is the role of a metabolic panel in the workup of diffuse large cell lymphoma?

When is CT scanning indicated in the workup of diffuse large cell lymphoma?

When is PET scanning indicated in the workup of diffuse large cell lymphoma?

When is bone marrow biopsy indicated in the workup of diffuse large cell lymphoma?

When is CNS imaging and lumbar puncture indicated in the workup of diffuse large cell lymphoma?

When are endoscopic procedures indicated in the workup of diffuse large cell lymphoma?

When are cardiac studies indicated in the workup of diffuse large cell lymphoma?

What is the role of serologic testing in the workup of diffuse large cell lymphoma?

What is the role of flow cytometry in the workup of diffuse large cell lymphoma?

What is the role of CT scanning in the workup of diffuse large cell lymphoma?

What is the role of Gallium-67 scans in the workup of diffuse large cell lymphoma?

What is the role of MUGA scanning in the workup of diffuse large cell lymphoma?

What is the role of PET scans in the workup of diffuse large cell lymphoma?

What is the role of biopsy in the workup of diffuse large cell lymphoma?

What is the role lumbar puncture in the workup of diffuse large cell lymphoma?

Which histologic findings are characteristic of diffuse large cell lymphoma?

What is the role of a pathological evaluation in the diagnosis of diffuse large cell lymphoma?

What is the pathologic classification of diffuse large cell lymphoma?

What are the pathologic characteristics of DLBCL?

What are the subclassifications of DLBCL?

Which genetic abnormalities are seen in DLBCL?

What is the molecular biology of DLBCL?

What is the role of NF kappa-B signaling in the molecular biology of DLBCL?

What is the role of BCR signaling in the molecular biology of DLBCL?

What are the distinct cytogenetic abnormalities in DLBCL subtypes?

How is diffuse large cell lymphoma staged?

What is the Ann Arbor staging system for diffuse large cell lymphoma?

Treatment

How is diffuse large cell lymphoma treated?

What is the role of the R-CHOP regimen in the treatment of diffuse large cell lymphoma?

What is the efficacy of R-DHAP in the treatment of relapsed diffuse large cell lymphoma?

Which regimen is effective in treating r/rDLBCL in patients ineligible for allogeneic stem cell transplantation (ASCT)?

What is the role of a venous access device in the treatment of diffuse large cell lymphoma?

How are patients with diffuse large cell lymphoma monitored?

How is early-stage DLBCL treated?

What is the role of radiation therapy in the treatment of early-stage DLBCL?

What is the role of rituximab in the treatment of early-stage DLBCL?

How is advance-stage diffuse large cell lymphoma treated?

What are the alternatives to CHOP for the treatment of advance-stage diffuse large cell lymphoma

What is the role of rituximab in the treatment of advanced-stage DLBCL?

What is the role of HDC-ASCS in the treatment of relapsed/refractory DLBCL?

What is the role of rituximab in the treatment of relapsed/refractory DLBCL?

What is the role of chemoimmunotherapy in the treatment of relapsed/refractory DLBCL?

What are the salvage chemotherapy regimens used in the treatment of DLBCL?

What are the types of salvage chemotherapy used in the treatment of DLBCL?

What are the platinum-based chemotherapy regimens used in the treatment of DLBCL?

What are the non-platinum-based chemotherapy regimens used in the treatment of DLBCL?

What are the risk factors for CNS relapse in DLBCL?

What is the role of intrathecal chemotherapy in the treatment of DLBCL?

What is the role of CAR T-cell therapy in the treatment of diffuse large cell lymphoma?

Which treatment regimens are being investigated for the treatment of diffuse large cell lymphoma?

What is included in supportive care for diffuse large cell lymphoma?

What is the role of antiemetics in the treatment of diffuse large cell lymphoma?

What is the role of growth factors in the treatment of diffuse large cell lymphoma?

When is impatient care indicated in the treatment of diffuse large cell lymphoma?

How is tumor lysis syndrome treated in patients with diffuse large cell lymphoma?

How is neutropenic fever treated in patients with diffuse large cell lymphoma?

How are anemia and thrombocytopenia treated in patients with diffuse large cell lymphoma?

Which dietary modifications are used in the treatment of diffuse large cell lymphoma?

Which activity modifications are used in the treatment of diffuse large cell lymphoma?

Which specialist consultations are beneficial to patients with diffuse large cell lymphoma?

When is patient transfer indicated in the treatment of diffuse large cell lymphoma?

Medications

What is the role of medications in the treatment of diffuse large cell lymphoma?

Which medications in the drug class Antiemetics are used in the treatment of Diffuse Large Cell Lymphoma?

Which medications in the drug class Antifungals, Other are used in the treatment of Diffuse Large Cell Lymphoma?

Which medications in the drug class Antidotes, Other are used in the treatment of Diffuse Large Cell Lymphoma?

Which medications in the drug class Vitamins are used in the treatment of Diffuse Large Cell Lymphoma?

Which medications in the drug class Antibiotics are used in the treatment of Diffuse Large Cell Lymphoma?

Which medications in the drug class Colony-Stimulating Factors Growth Factor are used in the treatment of Diffuse Large Cell Lymphoma?

Which medications in the drug class CAR T-cell Therapy are used in the treatment of Diffuse Large Cell Lymphoma?

Which medications in the drug class Antineoplastics, PI3K Delta Inhibitors are used in the treatment of Diffuse Large Cell Lymphoma?

Which medications in the drug class Monoclonal Antibodies are used in the treatment of Diffuse Large Cell Lymphoma?

Which medications in the drug class Corticosteroids are used in the treatment of Diffuse Large Cell Lymphoma?

Which medications in the drug class Antineoplastics, Other are used in the treatment of Diffuse Large Cell Lymphoma?