Overview
Where does non-Hodgkin lymphoma (NHL) originate?
Which factors determine the clinical presentation of non-Hodgkin lymphoma (NHL)?
What are the signs and symptoms of low-grade non-Hodgkin lymphoma (NHL)?
What are the signs and symptoms of intermediate- and high-grade non-Hodgkin lymphoma (NHL)?
Which physical findings are characteristic of non-Hodgkin lymphoma (NHL)?
Which lab tests are performed in the workup of suspected non-Hodgkin lymphoma (NHL)?
Which imaging studies are performed in the workup of suspected non-Hodgkin lymphoma (NHL)?
How is non-Hodgkin lymphoma (NHL) diagnosed?
When is lumbar puncture indicated in the workup of non-Hodgkin lymphoma (NHL)?
What is included in the standard of care for non-Hodgkin lymphoma (NHL)?
What is non-Hodgkin lymphoma (NHL)?
What is the pathophysiology of non-Hodgkin lymphoma (NHL)?
What causes non-Hodgkin lymphoma (NHL)?
What are the genetic causes of non-Hodgkin lymphoma (NHL)
What is the role of viral infection in the etiology of non-Hodgkin lymphoma (NHL)?
Which environmental factors increase the risk of non-Hodgkin lymphoma (NHL)?
What is the role of immunodeficiency in the etiology of non-Hodgkin lymphoma (NHL)?
What is the role of celiac disease in the etiology of non-Hodgkin lymphoma (NHL)?
What is the role of chronic inflammation in the etiology of non-Hodgkin lymphoma (NHL)?
What is the prevalence of non-Hodgkin lymphoma (NHL)?
Which age group has the highest prevalence of non-Hodgkin lymphoma (NHL)?
What are the survival rates of non-Hodgkin lymphoma (NHL)?
Which factors affect the prognosis of non-Hodgkin lymphoma (NHL)?
How is the prognosis of non-Hodgkin lymphoma (NHL) determined?
Which factors have prognostic significance in non-Hodgkin lymphoma (NHL)?
What is included in patient education about non-Hodgkin lymphoma (NHL)?
Presentation
How is non-Hodgkin lymphoma (NHL) graded?
Which clinical history findings are characteristic of low-grade non-Hodgkin lymphoma (NHL)?
Which physical findings are characteristic of low-grade non-Hodgkin lymphoma (NHL)?
What are the possible complications of non-Hodgkin lymphoma (NHL)?
DDX
Which conditions are included in the differential diagnoses of non-Hodgkin lymphoma (NHL)?
What are the differential diagnoses for Non-Hodgkin Lymphoma (NHL)?
Workup
Which studies are performed in the diagnostic workup of non-Hodgkin lymphoma (NHL)?
Which serum chemistry findings are characteristic of non-Hodgkin lymphoma (NHL)?
What is the significance of a finding of elevated beta2-microglobulin in non-Hodgkin lymphoma (NHL)?
Which lab results are occasionally found in non-Hodgkin lymphoma (NHL)?
When is HIV serology indicated in the workup of non-Hodgkin lymphoma (NHL)?
What is the significance of a finding of elevated CXCL13 in non-Hodgkin lymphoma (NHL)?
What is the role of chest radiography in the workup of non-Hodgkin lymphoma (NHL)?
What is the role of CT scanning in the workup of non-Hodgkin lymphoma (NHL)?
What is the role of bone scanning in the workup of non-Hodgkin lymphoma (NHL)?
What is the role of Gallium scanning in the workup of non-Hodgkin lymphoma (NHL)?
What is the role of PET scanning in the workup of non-Hodgkin lymphoma (NHL)?
What is the role of ultrasonography in the workup of non-Hodgkin lymphoma (NHL)?
What is the role of MUGA in the workup of non-Hodgkin lymphoma (NHL)?
What is the role of MRI in the workup of non-Hodgkin lymphoma (NHL)?
What is the role of biopsy in the workup of non-Hodgkin lymphoma (NHL)?
What is the role of bone marrow aspirate in the workup of non-Hodgkin lymphoma (NHL)?
What is the role of extranodal biopsy in the workup of non-Hodgkin lymphoma (NHL)?
What is the role of CSF analysis in the workup of non-Hodgkin lymphoma (NHL)?
Which histologic findings are characteristic of non-Hodgkin lymphoma (NHL)?
What is the role of immunophenotypic analysis in the workup of non-Hodgkin lymphoma (NHL)?
What is the role of cytogenic studies in the workup of non-Hodgkin lymphoma (NHL)?
How is non-Hodgkin lymphoma (NHL) staged?
How is risk stratified in non-Hodgkin lymphoma (NHL)?
Which CBC count findings are characteristic of non-Hodgkin lymphoma (NHL)?
Treatment
How is non-Hodgkin lymphoma (NHL) treated?
Which non-Hodgkin lymphomas (NHLs) are classified as indolent?
How are indolent stage I and indolent contiguous stage II non-Hodgkin lymphoma (NHL) treated?
How are indolent noncontiguous stages II, III and IV non-Hodgkin lymphoma (NHL) treated?
Which non-Hodgkin lymphomas (NHLs) are classified as aggressive?
How are aggressive stage I and aggressive contiguous stage II non-Hodgkin lymphoma (NHL) treated?
How are aggressive noncontiguous stages II, III and IV non-Hodgkin lymphoma (NHL) treated?
How is indolent recurrent non-Hodgkin lymphoma (NHL) treated?
How is aggressive recurrent non-Hodgkin lymphoma (NHL) treated?
How are T-cell non-Hodgkin lymphomas (NHLs) treated?
What is the role of surgery in the treatment of non-Hodgkin lymphoma (NHL)?
What are the possible treatment-related complications of non-Hodgkin lymphoma (NHL)?
What is tumor lysis syndrome in non-Hodgkin lymphoma (NHL) and how is it treated?
What is the risk of atherosclerosis following treatment of non-Hodgkin lymphoma (NHL)?
Which dietary modifications are used in the treatment of non-Hodgkin lymphoma (NHL)?
Which activity modifications are used in the treatment of non-Hodgkin lymphoma (NHL)?
How is non-Hodgkin lymphoma (NHL) treated during pregnancy?
What is the role of CAR T-cell therapy in the treatment of non-Hodgkin lymphoma (NHL)?
Which specialist consultations are beneficial to patients with non-Hodgkin lymphoma (NHL)?
What is included in the long-term monitoring of patients with non-Hodgkin lymphoma (NHL)?
Guidelines
What is included in the NCCN guidelines on non-Hodgkin lymphoma (NHL)?
How is non-Hodgkin lymphoma (NHL) classified?
What are the NCCN guidelines on the diagnosis of non-Hodgkin lymphoma (NHL)?
What are the NCCN guidelines on the staging of non-Hodgkin lymphoma (NHL)?
What is the International Prognostic Index (IPI) for non-Hodgkin lymphoma (NHL)?
What is the WHO classification of follicular lymphoma (FL)?
What are the NCCN and ESMO guidelines on the diagnosis of follicular lymphoma (FL)?
What are the GELF criteria for follicular lymphoma (FL) risk stratification?
What are the NCCN recommendations for follicular lymphoma (FL) risk stratification?
What is the FLIPI2 index for follicular lymphoma (FL) risk stratification?
What are the NCCN and ESMO guidelines on the treatment of follicular lymphoma (FL)?
What are the NCCN-recommend chemotherapy regimens for follicular lymphoma (FL)?
What are the NCCN and ESMO guidelines on the diagnosis of gastric MALT lymphoma?
How is gastric MALT lymphoma staged?
What are the NCCN and ESMO guidelines on staging gastric MALT lymphoma?
What are the NCCN and ESMO guidelines on the treatment of gastric MALT lymphoma?
What are the NCCN guidelines on the diagnosis of mantle cell lymphoma?
How is mantle cell lymphoma staged?
What are the NCCN and ESMO guidelines on the treatment of mantle cell lymphoma?
What are the NCCN guidelines on the diagnoses of diffuse large B-cell lymphoma (DLBCL)?
What is the IPI for risk stratification of diffuse large B-cell lymphoma (DLBCL)?
What are the NCCN guidelines on the treatment of diffuse large B-cell lymphoma (DLBCL)?
What are the ESMO guidelines on the treatment of diffuse large B-cell lymphoma (DLBCL)?
What are the NCCN guidelines for long-term monitoring of diffuse large B-cell lymphoma (DLBCL)?
What is the WHO classification of Burkitt lymphoma (BL)?
What are the NCCN guidelines on the diagnosis of Burkitt lymphoma (BL)?
How is risk stratified for Burkitt lymphoma (BL)?
What are the NCCN guidelines on the treatment of Burkitt lymphoma (BL)?
What are the NCCN guidelines for long-term monitoring of Burkitt lymphoma (BL)?
How is primary cutaneous B-cell lymphomas (CBCL) classified?
What are the NCCN guidelines on the diagnosis of primary cutaneous B-cell lymphomas (CBCL)?
How is primary cutaneous B-cell lymphomas (CBCL) staged?
What are the treatment guidelines for PC-FCL and PC-MZL?
What are the treatment guidelines for PC-DBCL, LT?
How is cutaneous T-cell lymphoma (CTCL) classified?
What are the NCCN guidelines on the diagnosis of mycosis fungoides/Sezary syndrome (MF/SS)?
How is mycosis fungoides/Sezary syndrome (MF/SS) staged?
What are the guidelines on the treatment of mycosis fungoides/Sezary syndrome (MF/SS)?
How are primary cutaneous CD30+ T-Cell lymphoproliferative disorders (CD30+LPDs) classified?
How are primary cutaneous CD30+ T-Cell lymphoproliferative disorders (CD30+LPDs) staged?
Medications
Which medications are used in the treatment of non-Hodgkin lymphoma (NHL)?
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Posteroanterior (PA) chest radiograph in a man with thoracic non-Hodgkin lymphoma (NHL) shows mediastinal widening due to grossly enlarged right paratracheal and left paratracheal nodes.
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Posteroanterior (PA) chest radiograph in a 16-year-old male adolescent with thoracic non-Hodgkin lymphoma (NHL) shows subtle enlargement of the lower paratracheal lymph nodes.
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Nonenhanced CT scan through the mediastinum shows multiple enlarged lymph nodes in the prevascular space, in the right and left paratracheal region. Nodes in the left paratracheal region cause the trachea to be indented and narrowed on the left side. Note the small, bilateral pleural effusion
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Nonenhanced CT scan through the mediastinum at the level of the carina shows enlarged tracheobronchial and subcarinal nodes. Note the small bilateral pleural effusion.
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Contrast-enhanced axial CT scan in a child shows hypoattenuating, enlarged, subcarinal lymph nodes with splaying of the tracheal bifurcation.
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Posteroanterior (PA) chest radiograph shows a large mass in the right parahilar region extending into the right upper and middle zones, with silhouetting of the right pulmonary artery. Smaller mass is seen in the periphery of the right lower zone. The masses did not respond to a trial of antibiotics. Core-needle biopsy of the larger lesion revealed NHL deposits in the lung.
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Lateral image shows a large mass in the anterior aspect of the right upper lobe of the lung.
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Posterior bone scan shows no abnormally increased uptake in the thoracic vertebrae. Image shows an unusual pattern of non-Hodgkin lymphoma (NHL) of the upper thoracic vertebra.
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This 28-year-old man was being evaluated for fever of unknown origin. Gallium-67 study shows extensive uptake in the mediastinal lymph nodes due to non-Hodgkin lymphoma (NHL).
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T1-weighted coronal MRI of the thorax in a 55-year-old woman with lower dorsal pain. Note the signal-intensity changes in the body of D12; these are associated with a right-sided, large, paravertebral soft-tissue mass involving the psoas muscle. Biopsy confirmed non-Hodgkin lymphoma (NHL).
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T1-weighted coronal MRI of the thorax in a 55-year-old woman with lower dorsal pain (same patient as in the previous image). Note the signal-intensity changes in the body of D12; these are associated with a right-sided, large, paravertebral soft-tissue mass involving the psoas muscle. Biopsy confirmed non-Hodgkin lymphoma (NHL).
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Positron emission tomography (PET) CT in an 80-year-old woman with diffuse, large B-cell NHL of the skin and subcutaneous tissues that recently transformed from previous low-grade non-Hodgkin lymphoma (NHL). PET shows high level of uptake in the anterior subcutaneous nodule in the chest (white arrows). CT scan of similar nodules (arrowheads) on the anterior left chest does not show PET uptake; these may represent regions of lower-grade NHL. PET image of posterior lesions shows only mild uptake (gray arrow).
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Non-Hodgkin lymphoma of the terminal ileum. Note the doughnut sign, ie, intraluminal contrast material surrounded by a grossly thickened bowel wall. This appearance is highly suggestive of small noncleaved cell lymphoma (Burkitt type).
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Computed tomography of the throat in highly-malignant non-hodgkin lymphoma present as lymph node swelling in a child (transverse section with contrast). DE: Computertomographie des Halses bei einem hoch-malignen Non-Hodgkin
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Malignant lymphoma high grade_B_cell
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Ultrasound throat lymphadenopathy non-hodgkin-lymphoma
Tables
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- Overview
- Presentation
- DDx
- Workup
- Approach Considerations
- Complete Blood Cell Count
- Serum Chemistry Studies
- Other Laboratory Studies
- Radiography
- CT, Bone Scan, and Gallium Scan
- Positron Emission Tomography and Ultrasonography
- Multiple Gated Acquisition Scanning
- Magnetic Resonance Imaging
- Biopsy
- Lumbar Puncture
- Histologic Findings
- Immunophenotypic Analysis
- Cytogenetic Studies
- Staging
- Show All
- Treatment
- Approach Considerations
- Management of Indolent NHL
- Management of Aggressive NHL
- Management of Indolent Recurrent NHL
- Management of Aggressive Recurrent Adult NHL
- Management of T-cell Lymphomas
- Surgical Care
- Complications of Therapy
- Dietary Modification
- Activity Restriction
- Management of NHL in Special Populations
- CAR T-cell Therapy
- Consultations
- Long-Term Monitoring
- Show All
- Guidelines
- Guidelines Summary
- Diagnosis
- Staging
- Risk Stratification
- Follicular Lymphoma
- Marginal Zone Lymphomas of MALT Type
- Mantle Cell Lymphoma
- Diffuse Large B-Cell Lymphoma
- Burkitt Lymphoma
- Primary Cutaneous B-Cell Lymphomas
- Cutaneous T-Cell Lymphoma
- Primary Cutaneous CD30+ T-Cell Lymphoproliferative Disorders
- Show All
- Medication
- Medication Summary
- Cytotoxic agents
- Antineoplastic Agents, Histone Deacetylase Inhibitors
- Antineoplastics, PI3K Inhibitors
- Monoclonal Antibodies
- Antineoplastic Agents, Proteasome Inhibitors
- Antineoplastic Agents, mTOR Kinase Inhibitors
- Antineoplastics, Angiogenesis Inhibitor
- PD-1/PD-L1 Inhibitors
- CAR T-cell Therapy
- Antineoplastics, Anti-CD19 Monoclonal Antibodies
- Colony-Stimulating Factor Growth Factors
- Immunomodulators
- Corticosteroids
- Show All
- Questions & Answers
- Media Gallery
- Tables
- References