Non-Hodgkin Lymphoma Questions & Answers

Updated: Jun 12, 2019
  • Author: Sanjay Vinjamaram, MD, MPH; Chief Editor: Emmanuel C Besa, MD  more...
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Questions & Answers

Overview

Where does non-Hodgkin lymphoma (NHL) originate?

Which factors determine the clinical presentation of non-Hodgkin lymphoma (NHL)?

What are the signs and symptoms of low-grade non-Hodgkin lymphoma (NHL)?

What are the signs and symptoms of intermediate- and high-grade non-Hodgkin lymphoma (NHL)?

Which physical findings are characteristic of non-Hodgkin lymphoma (NHL)?

Which lab tests are performed in the workup of suspected non-Hodgkin lymphoma (NHL)?

Which imaging studies are performed in the workup of suspected non-Hodgkin lymphoma (NHL)?

How is non-Hodgkin lymphoma (NHL) diagnosed?

When is lumbar puncture indicated in the workup of non-Hodgkin lymphoma (NHL)?

What is included in the standard of care for non-Hodgkin lymphoma (NHL)?

What is non-Hodgkin lymphoma (NHL)?

What is the pathophysiology of non-Hodgkin lymphoma (NHL)?

What causes non-Hodgkin lymphoma (NHL)?

What are the genetic causes of non-Hodgkin lymphoma (NHL)

What is the role of viral infection in the etiology of non-Hodgkin lymphoma (NHL)?

Which environmental factors increase the risk of non-Hodgkin lymphoma (NHL)?

What is the role of immunodeficiency in the etiology of non-Hodgkin lymphoma (NHL)?

What is the role of celiac disease in the etiology of non-Hodgkin lymphoma (NHL)?

What is the role of chronic inflammation in the etiology of non-Hodgkin lymphoma (NHL)?

What is the prevalence of non-Hodgkin lymphoma (NHL)?

Which age group has the highest prevalence of non-Hodgkin lymphoma (NHL)?

What are the survival rates of non-Hodgkin lymphoma (NHL)?

Which factors affect the prognosis of non-Hodgkin lymphoma (NHL)?

How is the prognosis of non-Hodgkin lymphoma (NHL) determined?

Which factors have prognostic significance in non-Hodgkin lymphoma (NHL)?

What is included in patient education about non-Hodgkin lymphoma (NHL)?

Presentation

How is non-Hodgkin lymphoma (NHL) graded?

Which clinical history findings are characteristic of low-grade non-Hodgkin lymphoma (NHL)?

Which clinical history findings are characteristic of intermediate- and high-grade non-Hodgkin lymphoma (NHL)?

Which physical findings are characteristic of low-grade non-Hodgkin lymphoma (NHL)?

Which physical findings are characteristic of intermediate- and high-grade non-Hodgkin lymphoma (NHL)?

What are the possible complications of non-Hodgkin lymphoma (NHL)?

DDX

Which conditions are included in the differential diagnoses of non-Hodgkin lymphoma (NHL)?

What are the differential diagnoses for Non-Hodgkin Lymphoma?

Workup

Which studies are performed in the diagnostic workup of non-Hodgkin lymphoma (NHL)?

Which CBC count findings are characteristic of non-Hodgkin lymphoma (NHL)?

Which serum chemistry findings are characteristic of non-Hodgkin lymphoma (NHL)?

What is the significance of a finding of elevated beta2-microglobulin in non-Hodgkin lymphoma (NHL)?

Which lab results are occasionally found in non-Hodgkin lymphoma (NHL)?

When is HIV serology indicated in the workup of non-Hodgkin lymphoma (NHL)?

What is the significance of a finding of elevated CXCL13 in non-Hodgkin lymphoma (NHL)?

What is the role of chest radiography in the workup of non-Hodgkin lymphoma (NHL)?

What is the role of CT scanning in the workup of non-Hodgkin lymphoma (NHL)?

What is the role of bone scanning in the workup of non-Hodgkin lymphoma (NHL)?

What is the role of Gallium scanning in the workup of non-Hodgkin lymphoma (NHL)?

What is the role of PET scanning in the workup of non-Hodgkin lymphoma (NHL)?

What is the role of ultrasonography in the workup of non-Hodgkin lymphoma (NHL)?

What is the role of MUGA in the workup of non-Hodgkin lymphoma (NHL)?

What is the role of MRI in the workup of non-Hodgkin lymphoma (NHL)?

What is the role of biopsy in the workup of non-Hodgkin lymphoma (NHL)?

What is the role of bone marrow aspirate in the workup of non-Hodgkin lymphoma (NHL)?

What is the role of extranodal biopsy in the workup of non-Hodgkin lymphoma (NHL)?

What is the role of CSF analysis in the workup of non-Hodgkin lymphoma (NHL)?

Which histologic findings are characteristic of non-Hodgkin lymphoma (NHL)?

What is the role of immunophenotypic analysis in the workup of non-Hodgkin lymphoma (NHL)?

What is the role of cytogenic studies in the workup of non-Hodgkin lymphoma (NHL)?

How is non-Hodgkin lymphoma (NHL) staged?

How is risk stratified in non-Hodgkin lymphoma (NHL)?

Treatment

How is non-Hodgkin lymphoma (NHL) treated?

Which non-Hodgkin lymphomas (NHLs) are classified as indolent?

How are indolent stage I and indolent contiguous stage II non-Hodgkin lymphoma (NHL) treated?

How are indolent noncontiguous stages II, III and IV non-Hodgkin lymphoma (NHL) treated?

Which non-Hodgkin lymphomas (NHLs) are classified as aggressive?

How are aggressive stage I and aggressive contiguous stage II non-Hodgkin lymphoma (NHL) treated?

How are aggressive noncontiguous stages II, III and IV non-Hodgkin lymphoma (NHL) treated?

How is indolent recurrent non-Hodgkin lymphoma (NHL) treated?

How is aggressive recurrent non-Hodgkin lymphoma (NHL) treated?

How are T-cell non-Hodgkin lymphomas (NHLs) treated?

What is the role of surgery in the treatment of non-Hodgkin lymphoma (NHL)?

What are the possible treatment-related complications of non-Hodgkin lymphoma (NHL)?

What is tumor lysis syndrome in non-Hodgkin lymphoma (NHL) and how is it treated?

What is the risk of atherosclerosis following treatment of non-Hodgkin lymphoma (NHL)?

Which dietary modifications are used in the treatment of non-Hodgkin lymphoma (NHL)?

Which activity modifications are used in the treatment of non-Hodgkin lymphoma (NHL)?

How is non-Hodgkin lymphoma (NHL) treated during pregnancy?

What is the role of CAR T-cell therapy in the treatment of non-Hodgkin lymphoma (NHL)?

Which specialist consultations are beneficial to patients with non-Hodgkin lymphoma (NHL)?

What is included in the long-term monitoring of patients with non-Hodgkin lymphoma (NHL)?

Guidelines

What is included in the NCCN guidelines on non-Hodgkin lymphoma (NHL)?

What guidelines have been issued by ESMO on the diagnosis and treatment of non-Hodgkin lymphoma (NHL)?

How is non-Hodgkin lymphoma (NHL) classified?

What are the NCCN guidelines on the diagnosis of non-Hodgkin lymphoma (NHL)?

What are the NCCN guidelines on the staging of non-Hodgkin lymphoma (NHL)?

What is the International Prognostic Index (IPI) for non-Hodgkin lymphoma (NHL)?

What is the WHO classification of follicular lymphoma (FL)?

What are the NCCN and ESMO guidelines on the diagnosis of follicular lymphoma (FL)?

What are the GELF criteria for follicular lymphoma (FL) risk stratification?

What are the NCCN recommendations for follicular lymphoma (FL) risk stratification?

What is the FLIPI2 index for follicular lymphoma (FL) risk stratification?

What are the NCCN and ESMO guidelines on the treatment of follicular lymphoma (FL)?

What are the NCCN-recommend chemotherapy regimens for follicular lymphoma (FL)?

What are the NCCN and ESMO guidelines on the diagnosis of gastric MALT lymphoma?

How is gastric MALT lymphoma staged?

What are the NCCN and ESMO guidelines on staging gastric MALT lymphoma?

What are the NCCN and ESMO guidelines on the treatment of gastric MALT lymphoma?

What are the NCCN guidelines on the diagnosis of mantle cell lymphoma?

How is mantle cell lymphoma staged?

What are the NCCN and ESMO guidelines on the treatment of mantle cell lymphoma?

What are the NCCN guidelines on the diagnoses of diffuse large B-cell lymphoma (DLBCL)?

What is the IPI for risk stratification of diffuse large B-cell lymphoma (DLBCL)?

What are the NCCN guidelines on the treatment of diffuse large B-cell lymphoma (DLBCL)?

What are the ESMO guidelines on the treatment of diffuse large B-cell lymphoma (DLBCL)?

What are the NCCN guidelines for long-term monitoring of diffuse large B-cell lymphoma (DLBCL)?

What is the WHO classification of Burkitt lymphoma (BL)?

What are the NCCN guidelines on the diagnosis of Burkitt lymphoma (BL)?

How is risk stratified for Burkitt lymphoma (BL)?

What are the NCCN guidelines on the treatment of Burkitt lymphoma (BL)?

What are the NCCN guidelines for long-term monitoring of Burkitt lymphoma (BL)?

Which organizations have published guidelines on the treatment of primary cutaneous B-cell lymphomas (CBCL)?

How is primary cutaneous B-cell lymphomas (CBCL) classified?

What are the NCCN guidelines on the diagnosis of primary cutaneous B-cell lymphomas (CBCL)?

How is primary cutaneous B-cell lymphomas (CBCL) staged?

What are the treatment guidelines for PC-FCL and PC-MZL?

What are the treatment guidelines for PC-DBCL, LT?

How is cutaneous T-cell lymphoma (CTCL) classified?

Which organizations have published guidelines on the treatment of mycosis fungoides/Sezary syndrome (MF/SS)?

What are the NCCN guidelines on the diagnosis of mycosis fungoides/Sezary syndrome (MF/SS)?

How is mycosis fungoides/Sezary syndrome (MF/SS) staged?

What are the guidelines on the treatment of mycosis fungoides/Sezary syndrome (MF/SS)?

Which organizations have issued guidelines on the treatment of primary cutaneous CD30+ T-Cell lymphoproliferative disorders (CD30+LPDs)?

How are primary cutaneous CD30+ T-Cell lymphoproliferative disorders (CD30+LPDs) classified?

What are the NCCN guidelines on the diagnosis of primary cutaneous CD30+ T-Cell lymphoproliferative disorders (CD30+LPDs)?

How are primary cutaneous CD30+ T-Cell lymphoproliferative disorders (CD30+LPDs) staged?

What are the guidelines on the treatment of primary cutaneous CD30+ T-Cell lymphoproliferative disorders (CD30+LPDs)?

Medications

Which medications are used in the treatment of non-Hodgkin lymphoma (NHL)?

Which medications in the drug class Corticosteroids are used in the treatment of Non-Hodgkin Lymphoma?

Which medications in the drug class Immunomodulators are used in the treatment of Non-Hodgkin Lymphoma?

Which medications in the drug class CAR-T cell Therapy are used in the treatment of Non-Hodgkin Lymphoma?

Which medications in the drug class PD-1/PD-L1 Inhibitors are used in the treatment of Non-Hodgkin Lymphoma?

Which medications in the drug class Antineoplastics, Angiogenesis Inhibitor are used in the treatment of Non-Hodgkin Lymphoma?

Which medications in the drug class Antineoplastic Agents, mTOR Kinase Inhibitors are used in the treatment of Non-Hodgkin Lymphoma?

Which medications in the drug class Antineoplastic Agents, Proteasome Inhibitors are used in the treatment of Non-Hodgkin Lymphoma?

Which medications in the drug class Antineoplastics, PI3K Delta Inhibitors are used in the treatment of Non-Hodgkin Lymphoma?

Which medications in the drug class Monoclonal Antibodies are used in the treatment of Non-Hodgkin Lymphoma?

Which medications in the drug class Colony-Stimulating Factor Growth Factors are used in the treatment of Non-Hodgkin Lymphoma?

Which medications in the drug class Antineoplastic Agents, Histone Deacetylase Inhibitors are used in the treatment of Non-Hodgkin Lymphoma?

Which medications in the drug class Cytotoxic agents are used in the treatment of Non-Hodgkin Lymphoma?