Macrocytosis Questions & Answers

Updated: Dec 16, 2018
  • Author: Vincent E Herrin, MD, FACP; Chief Editor: Emmanuel C Besa, MD  more...
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Questions & Answers

Overview

What is macrocytosis?

What are the causes of macrocytosis?

What is the pathophysiology of macrocytosis?

What is the role of hydroxyurea in the pathophysiology of macrocytosis?

What is the pathophysiology of macrocytosis in HIV-infected patients?

What are nonmegaloblastic macrocytic anemias?

What is the role of reticulocytes in the pathogenesis of macrocytosis?

What is the role of alcoholism to the development of macrocytosis?

What is the role of vitamin B-12 deficiency in the etiology of macrocytosis?

What are the causes of folate deficiency leading to macrocytosis?

Which inherited disorders of DNA synthesis lead to macrocytosis?

Which drugs cause macrocytosis?

What is the role of tyrosine kinase inhibitors in the etiology of macrocytosis?

What is reticulocytosis?

Which refractory anemias may cause macrocytosis?

What are possible etiologies of macrocytosis?

Presentation

What are the signs and symptoms of macrocytosis?

How does alcohol abuse lead to the development of macrocytosis?

Which physical findings are characteristic of macrocytosis?

DDX

Why is it important to determine the etiology of macrocytosis?

What are the differential diagnoses for Macrocytosis?

Workup

What is the role of lab studies in the workup of macrocytosis?

What is the role of bone marrow biopsy in the workup of macrocytosis?

Which histologic findings indicate macrocytosis?

Treatment

What are the treatment options for macrocytosis?

What dietary modifications are used in the treatment of macrocytosis?

Medications

What is the goal of drug treatment for macrocytosis?

Which medications in the drug class Vitamins are used in the treatment of Macrocytosis?