Systemic Mastocytosis Questions & Answers

Updated: Jun 21, 2021
  • Author: Devapiran Jaishankar, MBBS; Chief Editor: Emmanuel C Besa, MD  more...
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Questions & Answers

Overview

How is systemic mastocytosis characterized?

What are the signs and symptoms of systemic mastocytosis?

Which studies are performed in the diagnostic workup of systemic mastocytosis?

How is systemic mastocytosis diagnosed?

What is included in symptom management of systemic mastocytosis?

Which medications are used in the treatment of systemic mastocytosis?

What is systemic mastocytosis?

What is the pathophysiology of systemic mastocytosis?

How is systemic mastocytosis related to myeloproliferative disorders?

What is the role of genetics in the pathophysiology of systemic mastocytosis?

What is the prevalence of systemic mastocytosis?

What is the mortality and morbidity associated with systemic mastocytosis?

Which patient groups have the highest prevalence of systemic mastocytosis?

Presentation

Which systems may be symptomatic in systematic mastocytosis?

Which clinical history findings are characteristic of systematic mastocytosis?

Which GI findings are characteristic of systematic mastocytosis?

What causes recurrent anaphylactoid reaction in systematic mastocytosis?

Which hematologic findings may be present in systematic mastocytosis?

Which physical findings are characteristic of systemic mastocytosis?

What causes systemic mastocytosis?

DDX

Which conditions are included in the differential diagnoses of systemic mastocytosis?

Which conditions are included in the differential diagnoses of systemic mastocytosis with bone marrow involvement?

What are the differential diagnoses for Systemic Mastocytosis?

Workup

What is the role of lab tests in the workup of systemic mastocytosis?

What is the role of imaging studies in the workup of systemic mastocytosis?

What is the role of genetic testing in the workup of systemic mastocytosis?

When is biopsy indicated in the workup of systemic mastocytosis?

Which histologic findings are characteristic of systemic mastocytosis?

What are the diagnostic criteria for systemic mastocytosis?

How is systemic mastocytosis classified?

Treatment

How are the symptoms of systemic mastocytosis treated?

How is systemic mastocytosis-related anaphylaxis treated?

How is systemic mastocytosis treated?

What precautions should be taken for patients with systemic mastocytosis undergoing surgical procedures?

Which specialist consultations are beneficial to patients with systemic mastocytosis?

Which activity modifications are used in the treatment of systemic mastocytosis?

Medications

What is the role of medications in the treatment of systemic mastocytosis?

Which medications in the drug class Corticosteroids are used in the treatment of Systemic Mastocytosis?

Which medications in the drug class Mast Cell Stabilizers are used in the treatment of Systemic Mastocytosis?

Which medications in the drug class Sympathomimetics are used in the treatment of Systemic Mastocytosis?

Which medications in the drug class Antineoplastics, Tyrosine Kinase Inhibitor are used in the treatment of Systemic Mastocytosis?

Follow-up

What is the prognosis of systemic mastocytosis?

What is included in patient education about systemic mastocytosis?