Megaloblastic Anemia Differential Diagnoses

Updated: Jan 06, 2017
  • Author: Paul Schick, MD; Chief Editor: Emmanuel C Besa, MD  more...
  • Print

Diagnostic Considerations

Occasionally, the morphologic changes in hematopoietic cells are extremely bizarre and can be misinterpreted as neoplasia, acute leukemia, or myelodysplasia.

It is very important to distinguish between cobalamin and folate deficiencies since the treatment of the former with folate but not cobalamin can lead to the progression of neurological impairment.

One must distinguish among the various causes of cobalamin and folate deficiencies as described above, because treatment differs accordingly.

Other potential causes of macrocytosis (liver disease, hypothyroidism, and hemolytic anemia) should be considered in the differential diagnosis.

Go to Anemia ,Chronic Anemia ,Megaloblastic Anemia ,Myelophthisic Anemia ,Hemolytic Anemia ,and Sideroblastic Anemias for complete information on these topics.