Monoclonal Gammopathies of Undetermined Significance (MGUS) Clinical Presentation

Updated: Feb 11, 2020
  • Author: Suzanne R Fanning, DO; Chief Editor: Emmanuel C Besa, MD  more...
  • Print

History and Physical Examination

Monoclonal gammopathy of undetermined significance (MGUS) is usually an unexpected finding during an evaluation for an unrelated disorder. The advances in quantification of an M-spike by immunofixation contribute to the increasing number of patients identified as having MGUS.

No specific abnormalities are detected on physical examination in patients with MGUS. Several syndromes of polyneuropathies are associated with plasma cell dyscrasias, including MGUS. Paraproteinemic neuropathy (PPN) is most commonly observed with IgM gammopathy (48%), followed by IgG (37%), and IgA (15%).  [31]