Monoclonal Gammopathies of Undetermined Significance Questions & Answers

Updated: Sep 07, 2018
  • Author: Suzanne R Fanning, DO; Chief Editor: Emmanuel C Besa, MD  more...
  • Print
Questions & Answers

Overview

What is monoclonal gammopathy of undetermined significance (MGUS)?

What is the pathophysiology of monoclonal gammopathy of undetermined significance (MGUS)?

What are the genetic abnormalities in monoclonal gammopathy of undetermined significance (MGUS)?

What is the risk of progression to multiple myeloma (MM) from monoclonal gammopathy of undetermined significance (MGUS)?

What is the prevalence of monoclonal gammopathy of undetermined significance (MGUS)?

What is the mortality and morbidity associated with monoclonal gammopathy of undetermined significance (MGUS)?

What are the race-related differences in the incidence of monoclonal gammopathy of undetermined significance (MGUS)?

Is monoclonal gammopathy of undetermined significance (MGUS) more common in men or women?

What are the age-related differences in the incidence of monoclonal gammopathy of undetermined significance (MGUS)?

What is the prognosis of monoclonal gammopathy of undetermined significance (MGUS)?

Which factors are associated with the progression of monoclonal gammopathy of undetermined significance (MGUS) to myeloid malignancy?

What is the risk of venous thromboembolism (VTE) in patients with monoclonal gammopathy of undetermined significance (MGUS)?

What is the risk of osteoporosis in patients with monoclonal gammopathy of undetermined significance (MGUS)?

What is the risk of infection in patients with monoclonal gammopathy of undetermined significance (MGUS)?

Presentation

What are the clinical history and physical exam findings in monoclonal gammopathy of undetermined significance (MGUS)?

DDX

What are the diagnostic criteria for monoclonal gammopathy of undetermined significance (MGUS)?

What are the diagnostic considerations in monoclonal gammopathy of undetermined significance (MGUS)?

What are the differential diagnoses for Monoclonal Gammopathies of Undetermined Significance?

Workup

What is included in the workup of monoclonal gammopathy of undetermined significance (MGUS)?

What is the role of bone marrow exam in the workup of monoclonal gammopathy of undetermined significance (MGUS)?

What are the characteristic lab findings in monoclonal gammopathy of undetermined significance (MGUS)?

What lab testing is indicated in the surveillance of monoclonal gammopathy of undetermined significance (MGUS)?

Treatment

How is monoclonal gammopathy of undetermined significance (MGUS) managed?

What are the approach considerations in the treatment of monoclonal gammopathy of undetermined significance (MGUS)?

What is involved in the long-term monitoring of monoclonal gammopathy of undetermined significance (MGUS)?

What are the recommendations for long-term monitoring of monoclonal gammopathy of undetermined significance (MGUS)?

What is the recommended follow-up for patients with monoclonal gammopathy of undetermined significance (MGUS) at risk for malignant progression?

Medications

What is the role of drug treatment for monoclonal gammopathy of undetermined significance (MGUS)?