Myelophthisic Anemia Clinical Presentation

Updated: Jan 10, 2022
  • Author: Emmanuel C Besa, MD; Chief Editor: Sara J Grethlein, MD, MBA, FACP  more...
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History and Physical Examination

Focus the history and physical examination on establishing the underlying disease, such as an advanced carcinoma, lymphoma, or granulomatous disease. Family history is important for eliciting information in congenital and inherited forms of the disease.

Physical findings usually reflect the underlying medical condition, such as metastatic carcinoma, lymphoma, or tuberculosis. Anemia may cause skin pallor. Severe thrombocytopenia may produce petechiae or ecchymoses. Patients with severe neutropenia may become infected and present with fever.

Patients with myelophthisic anemia secondary to cobalamin deficiency may also present with leukoerythroblastosis, a hemolytic picture, and splenomegaly. [8]