Myelophthisic Anemia Medication

Updated: Jan 10, 2022
  • Author: Emmanuel C Besa, MD; Chief Editor: Sara J Grethlein, MD, MBA, FACP  more...
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Medication Summary

Correction of anemia often requires blood and/or blood products. The therapy is used to restore the hemodynamics of the vascular system and replace lost red blood cells. Major morbidities of anemia can be prevented by providing timely transfusion to restore hemoglobin to safe levels.


Blood Product Derivatives

Class Summary

Some agents in this category are used as needed to treat anemia.

Packed red blood cells

Packed red blood cells (PRBCs) are used preferentially to whole blood because they limit volume, immune, and storage complications. PRBCs have 80% less plasma, are less immunogenic, and can be stored for about 40 days (vs 35 d for whole blood). PRBCs are obtained after centrifugation of whole blood. Leukocyte-poor PRBCs are used in patients who are transplantation candidates/recipients or in those with prior febrile transfusion reactions. Washed or frozen PRBCs are used in individuals with hypersensitivity transfusion reactions.