Myelophthisic Anemia Treatment & Management

Updated: Jan 10, 2022
  • Author: Emmanuel C Besa, MD; Chief Editor: Sara J Grethlein, MD, MBA, FACP  more...
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Approach Considerations

Treat the underlying disease and provide supportive measures for symptomatic patients. Treat anemia with packed red blood cell transfusions. Rarely, patients have low erythropoietin levels and may respond to supplemental erythropoietin therapy. Patients with other cytopenias generally do not need treatment unless bleeding or infection is present.

In a case report, melanoma metastases causing myelophthisis and pancytopenia responded to immune checkpoint inhibition with the anti-programmed cell death-1 (PD-1) inhibitor pembrolizumab.

Consultation with a hematologist and an oncologist is warranted.

Go to Anemia, Chronic Anemia, Megaloblastic Anemia, Myelophthisic Anemia, Hemolytic Anemia, and Sideroblastic Anemias for complete information on these topics.