Neutropenia Questions & Answers

Updated: Sep 18, 2018
  • Author: Christopher D Braden, DO; Chief Editor: Emmanuel C Besa, MD  more...
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Questions & Answers

Overview

What is neutropenia?

What are the signs and symptoms of neutropenia?

What are the signs and symptoms of agranulocytosis?

Which physical findings are characteristic of neutropenia?

Which physical findings are characteristic of agranulocytosis?

Which lab tests are performed in the workup of neutropenia?

When is bone marrow aspiration indicated in the diagnostic workup of neutropenia?

How is neutropenia treated?

What is the role of antibiotic therapy in the treatment of neutropenia?

What are the ASCO/ISDA treatment guidelines for neutropenia?

What is the role of splenectomy in the treatment of neutropenia?

What is neutropenia?

How is neutropenia classified?

What is the pathophysiology of neutropenia?

What is the pathogenesis of neutropenia?

What is the role of infection in the pathophysiology of neutropenia?

What causes neutropenia?

What are the genetic causes of neutropenia?

What causes acquired neutropenia?

What causes congenital neutropenia with associated immune defects?

What is severe congenital neutropenia (SCN) (Kostmann syndrome)?

What is chronic benign neutropenia?

What is idiopathic chronic severe neutropenia?

Which phenotypic abnormalities are associated with neutropenia?

What is myelokathexis?

What is lazy leukocyte syndrome?

Which metabolic disorders are associated with neutropenia?

Which bone marrow diseases cause neutropenia?

Which medications cause drug immune-mediated neutropenia?

What causes autoimmune neutropenia?

What is isoimmune neonatal neutropenia?

What causes chronic autoimmune neutropenia and how is it treated?

What is T-gamma lymphocytosis neutropenia?

Which infections may cause neutropenia?

Which nutritional deficiencies cause neutropenia?

Which medications cause neutropenia?

What causes immunologic neutropenia?

Which conditions are associated with eosinopenia?

Which conditions are associated with basophilopenia?

What is the prevalence of neutropenia?

Which age groups have the highest prevalence of neutropenia?

What are the sexual predilections of neutropenia?

What are the racial predilections of neutropenia?

What is the prognosis of neutropenia?

What is the prognosis of neutropenia in persons with cancer?

What is the prognosis of agranulocytosis?

What is included in patient education about neutropenia?

Where can patient education resources about neutropenia be found?

Presentation

What are the signs and symptoms of neutropenia?

What are the signs and symptoms of agranulocytosis?

What is the focus of the clinical history for neutropenia?

What is included in the physical exam for evaluation of neutropenia?

Which physical findings are characteristic of neutropenia?

How is febrile neutropenia defined?

DDX

Which conditions should be included in the differential diagnoses of neutropenia?

What are the differential diagnoses for Neutropenia?

Workup

Which tests are performed in the workup of neutropenia?

Which lab tests are performed in the workup of neutropenia?

What is the role of Wright-stained peripheral smear in the diagnosis of neutropenia?

Which lab tests may be useful in the evaluation of neutropenia?

What is the role of antineutrophil antibody testing in the diagnosis of neutropenia?

What is the role of imaging studies in the evaluation of neutropenia?

What is included in the workup of fever in patients with neutropenia?

What is the role of bone marrow aspiration and biopsy in the diagnosis of neutropenia?

Treatment

How is neutropenia treated?

Which supportive measures should be taken in patients with neutropenia?

Which antibiotics are used to treat fever in neutropenia?

Which antimicrobials are used to treat resistant infections in neutropenia?

How is fever treated in low-risk neutropenia?

What is the role of colony-stimulating factor therapy in the treatment of neutropenia?

What are the NCCN guidelines for use of myeloid growth factors in the treatment of neutropenia?

What are the ASCO guidelines for the use of white blood cell growth factors in the treatment of neutropenia?

What are the European guidelines for use of G-CSFs in the treatment of neutropenia?

What is the role of granulocyte transfusion in the treatment of neutropenia?

What supportive treatments may be beneficial to patients with neutropenia?

What is the role of splenectomy in the treatment of neutropenia?

When is catheter removal indicated in the treatment of neutropenia?

What dietary measures are indicated in patients with neutropenia?

Which specialist consultations are beneficial to patients with neutropenia?

What is included in the long-term monitoring of neutropenia?

Medications

What is the role of medications in the treatment of neutropenia?

Which medications in the drug class Hematopoietic Growth Factors are used in the treatment of Neutropenia?

Which medications in the drug class Antifungal Agents are used in the treatment of Neutropenia?

Which medications in the drug class Antibiotics are used in the treatment of Neutropenia?