Protein C Deficiency Questions & Answers

Updated: Jan 04, 2019
  • Author: Shamudheen Rafiyath, MD; Chief Editor: Perumal Thiagarajan, MD  more...
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Questions & Answers

Overview

What is protein C deficiency?

What is the pathophysiology of protein C deficiency?

What is the role of genetics in the pathophysiology of protein C deficiency?

What is the pathophysiology of type I protein C deficiency?

What is the pathophysiology of type II protein C deficiency?

What is the prevalence of protein C deficiency?

What is the morbidity associated with protein C deficiency?

What is the morbidity associated with VTE in protein C deficiency?

What is the morbidity associated with WISN in protein C deficiency?

What is the effect of protein C deficiency on pregnancy outcome?

What is the morbidity associated with arterial thrombosis in protein C deficiency?

What is the morbidity associated with peripheral arterial disease in protein C deficiency?

What is the morbidity associated with NPF in protein C deficiency?

What are the racial predilections of protein C deficiency?

What are the sexual predilections of protein C deficiency?

Which age groups have the highest prevalence of protein C deficiency?

Presentation

Which clinical history findings are characteristic of protein C deficiency?

Which clinical history findings are characteristic of VTE in protein C deficiency?

Which clinical history findings are characteristic of WISN in protein C deficiency?

Which clinical history findings are characteristic of NPF in protein C deficiency?

Which physical findings are characteristic of protein C deficiency?

Which physical findings are characteristic of VTE in protein C deficiency?

Which physical findings are characteristic of WISN in protein C deficiency?

Which physical findings are characteristic of NPF in protein C deficiency?

What causes protein C deficiency?

What causes acquired protein C deficiency?

DDX

Which conditions are included in the differential diagnoses of protein C deficiency with VTE?

Which conditions are included in the differential diagnoses of protein C deficiency with WISN?

What are the differential diagnoses for Protein C Deficiency?

Workup

What types of lab tests are performed in the workup of protein C deficiency?

What is the role of immunologic assays in the workup of protein C deficiency?

What is the role of functional assays in the role of the workup of protein C deficiency?

How is the diagnosis of protein C deficiency confirmed?

How is protein C deficiency diagnosed in patients with acute thrombosis?

How is protein C deficiency diagnosed in patients taking warfarin?

Treatment

How is protein C deficiency treated?

How is venous thromboembolism in protein C deficiency treated?

How is WISN in protein C deficiency treated?

How is NPF in protein C deficiency treated?

Which specialist consultations are beneficial to protein C deficiency?

Which dietary and activity modification are used in the treatment of protein C deficiency?

Medications

What is the role of medications in the treatment of protein C deficiency?

Which medications in the drug class Sources of Exogenous Protein C are used in the treatment of Protein C Deficiency?

Which medications in the drug class Anticoagulant Agents are used in the treatment of Protein C Deficiency?

Follow-up

When is thromboprophylaxis indicated in the treatment of protein C deficiency?

How is WISN prevented in protein C deficiency?

What should patients with protein C deficiency be educated about?