Hereditary Pyropoikilocytosis Differential Diagnoses

Updated: Aug 24, 2021
  • Author: Nellowe C Candelario, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Diagnostic Considerations

In neonatal poikilocytosis, which occurs almost exclusively in African-American families, newborns and infants have severe hemolytic anemia that typically resolves after the first year of life. Transfusions and phototherapy may be required during severe hemolytic anemia and jaundice. The resolution of symptoms after a year helps distinguish neonatal poikilocytosis from hereditary pyropoikilocytosis.

Differential Diagnoses