Felon Organism-Specific Therapy 

Updated: Apr 12, 2019
Author: Ramotsumi M Makhene, MD; Chief Editor: Thomas E Herchline, MD 

Specific Organisms and Therapeutic Regimens

Organism-specific therapeutic regimens for felons are provided below, including those for methicillin-susceptible Staphylococcus aureus, methicillin-resistant S aureus, and gram-negative organisms.[1, 2, 3, 4, 5, 6, 7, 8, 9]

Adequate early treatment of a felon can prevent abscess formation. Treatment includes incision and drainage along with antibiotic therapy.[10] Pack gauze loosely into the wound to prevent skin closure, apply a loose dressing, and splint and elevate the finger. Antibiotic therapy should be determined on the basis of the results of the culture and sensitivity studies.

Staphylococcus aureus (methicillin susceptible) or streptococci

See the list below:

  • Amoxicillin-clavulanate (875mg/125mg) PO BID or

  • Cephalexin 500mg PO QID or

  • Clindamycin 300-450mg PO TID

  • Duration of therapy: 7-10d

Staphylococcus aureus (methicillin resistant)

See the list below:

  • Doxycycline 100mg PO BID or

  • Trimethoprim-sulfamethoxazole (160mg/800mg) 1 DS tablet PO BID or

  • Clindamycin 300-450mg PO TID

  • Duration of therapy: 7-10d

Gram-negative organisms

See the list below:

  • Ciprofloxacin 500mg PO BID or

  • Levofloxacin 500mg PO daily or

  • Doxycycline 100mg PO BID or

  • Trimethoprim-sulfamethoxazole (160mg/800mg) 1 DS tablet PO BID

  • Duration of therapy: 7-10d