Essential Thrombocytosis Questions & Answers

Updated: Aug 22, 2019
  • Author: Asheesh Lal, MBBS, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Questions & Answers

Overview

What is essential thrombocytosis (primary thrombocythemia)?

What is the pathophysiology of essential thrombocytosis (primary thrombocythemia)?

What is the prevalence of essential thrombocytosis (primary thrombocythemia) in the US?

What is the mortality and morbidity associated with essential thrombocytosis (primary thrombocythemia)?

What are the sexual predilections of essential thrombocytosis (primary thrombocythemia)?

Which age group has the highest prevalence of essential thrombocytosis (primary thrombocythemia)?

Presentation

Which clinical history findings are characteristic of essential thrombocytosis (primary thrombocythemia)?

What are the bleeding complications of essential thrombocytosis (primary thrombocythemia)?

What are the constitutional signs and symptoms of essential thrombocytosis (primary thrombocythemia)?

How does essential thrombocytosis (primary thrombocythemia) affect pregnancy outcomes?

Which physical findings are characteristic of essential thrombocytosis (primary thrombocythemia)?

What causes essential thrombocytosis (primary thrombocythemia)?

DDX

What are the diagnostic criteria for essential thrombocytosis (primary thrombocythemia)?

What are the differential diagnoses for Essential Thrombocytosis?

Workup

How is essential thrombocytosis (primary thrombocythemia) diagnosed?

Which histologic findings are characteristic of essential thrombocytosis (primary thrombocythemia)?

What is the role of blood testing in the workup of essential thrombocytosis (primary thrombocythemia)?

What is the role of genetic testing in the workup of essential thrombocytosis (primary thrombocythemia)?

What is the prevalence of CALR gene mutation in essential thrombocytosis (primary thrombocythemia)?

What is the role of bone marrow biopsy in the workup of essential thrombocytosis (primary thrombocythemia)?

Treatment

How is treatment selected for essential thrombocytosis (primary thrombocythemia)?

How is essential thrombocytosis (primary thrombocythemia) treated?

What is the role of cytoreductive therapy in the treatment of essential thrombocytosis (primary thrombocythemia)?

What precautions are taken for patients with essential thrombocytosis (primary thrombocythemia) undergoing surgery?

Which specialist consultations are beneficial to patients with essential thrombocytosis (primary thrombocythemia)?

Medications

What is the role of medications in the treatment of essential thrombocytosis (primary thrombocythemia)?

Which medications in the drug class Antineoplastics, Alkylating are used in the treatment of Essential Thrombocytosis?

Which medications in the drug class Biological Response Modifiers are used in the treatment of Essential Thrombocytosis?

Which medications in the drug class Kinase Inhibitors are used in the treatment of Essential Thrombocytosis?

Which medications in the drug class PDE-3 Inhibitors are used in the treatment of Essential Thrombocytosis?

Which medications in the drug class Antimetabolites are used in the treatment of Essential Thrombocytosis?

Follow-up

What are the possible complications of essential thrombocytosis (primary thrombocythemia)?

What is the prognosis of essential thrombocytosis (primary thrombocythemia)?