von Willebrand Disease Questions & Answers

Updated: Mar 11, 2021
  • Author: Eleanor S Pollak, MD; Chief Editor: Srikanth Nagalla, MD, MS, FACP  more...
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Questions & Answers

Overview

What is von Willebrand disease (vWD)?

What is von Willebrand factor (vWF)?

What are the types of von Willebrand disease (vWD)?

What is the most common type of von Willebrand disease (vWD)?

What are the treatment options for von Willebrand disease (vWD)?

Where can patient education information on von Willebrand disease (vWD) be found?

What is the role of genetics in the etiology of von Willebrand disease (vWD)?

What are characteristics of von Willebrand factor (vWF)?

What causes von Willebrand disease (vWD) type 1?

What causes von Willebrand disease (vWD) type 2?

What causes von Willebrand disease (vWD) type 2B?

What causes von Willebrand disease (vWD) type 2N?

What causes von Willebrand disease (vWD) type 2M?

What causes von Willebrand disease (vWD) type 3?

What causes acquired von Willebrand disease (vWD)?

What is the prevalence of von Willebrand disease (vWD)?

How does the prevalence of von Willebrand disease (vWD) vary by sex?

At what age do symptoms of von Willebrand disease (vWD) first appear?

What is the prognosis of von Willebrand disease (vWD)?

What is the prognosis of von Willebrand disease (vWD) types 2 and 3?

Presentation

What are the most common signs and symptoms of von Willebrand disease (vWD)?

Which-specific bleeding is characteristic of von Willebrand disease (vWD) in children?

What should be the focus of history in the evaluation for von Willebrand disease (vWD)?

How are bleeding assessment tools (BATs) used in the evaluation for von Willebrand disease (vWD)?

What is the accuracy of the Self-BAT score for the evaluation of von Willebrand disease (vWD)?

What is included in the physical exam of suspected von Willebrand disease (vWD)?

DDX

Which conditions are considered in the differential diagnosis of von Willebrand disease (vWD)?

What are the differential diagnoses for von Willebrand Disease?

Workup

What is the role of lab studies in the diagnosis of von Willebrand disease (vWD)?

Why is repeating tests needed to confirm the diagnosis of von Willebrand disease (vWD)?

Which lab tests are used to screen for von Willebrand disease (vWD)?

What is the role of blood typing in the diagnosis of von Willebrand disease (vWD)?

What is the role of genetic testing in the diagnosis of von Willebrand disease (vWD)?

How is von Willebrand factor (vWF) assessed in the evaluation of von Willebrand disease (vWD)?

What is the role of ristocetin cofactor (RCoF) testing in the evaluation of von Willebrand disease (vWD)?

Which ristocetin cofactor (RCoF) value is diagnostic of von Willebrand disease (vWD)?

What non ristocetin-dependent tests for Willebrand factor (vWF) are used in the diagnosis of Willebrand disease (vWD)?

What is the role of the vWF antigen (vWF:Ag) assay in the diagnosis of von Willebrand disease (vWD)?

What is the role of the template bleeding time test in the diagnosis of von Willebrand disease (vWD)?

Which activated partial thromboplastin time (aPTT) test results suggest von Willebrand disease (vWD)?

Which prothrombin time (PT) test results suggest von Willebrand disease (vWD)?

How is von Willebrand disease (vWD) type 1 diagnosed?

How is von Willebrand disease (vWD) type 2A diagnosed?

How is von Willebrand disease (vWD) type 2B diagnosed?

How is von Willebrand disease (vWD) type 2M diagnosed?

How is von Willebrand disease (vWD) type 2N diagnosed?

What is the role of multimeric exam in the diagnosis of von Willebrand disease (vWD) type 2?

How is von Willebrand disease (vWD) type 3 diagnosed?

When is low von Willebrand factor (vWF) diagnosed?

Why is response to administration of desmopressin (DDAVP) evaluated following the diagnosis of von Willebrand disease (vWD)?

Treatment

What are the treatment options for von Willebrand disease (vWD)?

What is the efficacy of recombinant von Willebrand factor (Vonvendi) for the treatment of von Willebrand disease (vWD)?

What is the role of antifibrinolytic drugs in the treatment of von Willebrand disease (vWD)?

When is platelet transfusion indicated for the treatment of von Willebrand disease (vWD)?

What prophylaxis is given prior to surgery in patients with von Willebrand disease (vWD)?

How does pregnancy affect the levels of von Willebrand factor (vWF) in patients with non-type 3 von Willebrand disease (vWD)?

What are the possible complications in pregnant patients with von Willebrand disease (vWD) type 2?

What should be avoided by patients with von Willebrand disease (vWD)?

What is the treatment of choice for von Willebrand disease (vWD) type 1?

What are the effects of desmopressin (DDAVP) in patients with von Willebrand disease (vWD) type 1?

How is desmopressin (DDAVP) administered for the treatment of von Willebrand disease (vWD) type 1?

What are the regimens for desmopressin (DDAVP) for the treatment of von Willebrand disease (vWD) type 1?

What are common complications of desmopressin (DDAVP) in the treatment of von Willebrand disease (vWD) type 1?

How is desmopressin (DDAVP) used in the treatment of von Willebrand disease (vWD) type 2?

What are the limitations to desmopressin (DDAVP) in the treatment of von Willebrand disease (vWD) type 2?

When is desmopressin (DDAVP) contraindicated for the treatment of von Willebrand disease (vWD) type 2?

What is the role of desmopressin (DDAVP) in the treatment of von Willebrand disease (vWD) type 3?

What is the treatment of choice for von Willebrand disease (vWD) type 3?

What are possible complications of von Willebrand disease (vWD) type 3?

Medications

What are the principal drug categories used in the treatment of von Willebrand disease (vWD)?

Which von Willebrand disease (vWD) types are treated with desmopressin (DDAVP)?

Which medications in the drug class Estrogens are used in the treatment of von Willebrand Disease?

Which medications in the drug class Vasopressin-Related are used in the treatment of von Willebrand Disease?

Which medications in the drug class Antifibrinolytic Agents are used in the treatment of von Willebrand Disease?

Which medications in the drug class Coagulation Factors are used in the treatment of von Willebrand Disease?