Waldenstrom Macroglobulinemia Questions & Answers

Updated: May 29, 2020
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Questions & Answers

Overview

What is Waldenström macroglobulinemia?

How is Waldenström macroglobulinemia managed?

What is the clinical presentation of Waldenström macroglobulinemia?

What are the complications of Waldenström macroglobulinemia?

What is the pathophysiology of Waldenström macroglobulinemia?

What causes Waldenström macroglobulinemia?

What are the demographics of Waldenström macroglobulinemia?

What is the prognosis of Waldenström macroglobulinemia?

What are poor prognostic factors of Waldenström macroglobulinemia?

How effective are the treatments for Waldenström macroglobulinemia?

What is the morbidity and mortality of Waldenström macroglobulinemia?

Presentation

How is the onset of Waldenström macroglobulinemia characterized?

What mental status changes are associated with Waldenström macroglobulinemia?

Which symptoms of Waldenström macroglobulinemia are due to hyperviscosity syndrome?

What is visual changes are associated with Waldenström macroglobulinemia?

What are the physical exam findings of Waldenström macroglobulinemia?

How is neuropathy in Waldenström macroglobulinemia characterized?

What are the cutaneous manifestations of Waldenström macroglobulinemia?

Which physical exam findings are rare in Waldenström macroglobulinemia?

DDX

What are the differential diagnoses for Waldenstrom Macroglobulinemia?

Workup

What are approach considerations in the workup of Waldenström macroglobulinemia?

Which lab and imaging studies are indicated in the workup of Waldenström macroglobulinemia?

What are the peripheral smear findings in the workup of Waldenström macroglobulinemia?

Which chemistry tests are indicated in the workup of Waldenström macroglobulinemia?

What lab study findings are associated with Waldenström macroglobulinemia?

Which serum protein electrophoresis findings are consistent with Waldenström macroglobulinemia?

What is the role of immunoelectrophoresis and immunofixation studies in the workup of Waldenström macroglobulinemia?

Which imaging studies are indicated in the workup of Waldenström macroglobulinemia?

What flow cytometry results are consistent with Waldenström macroglobulinemia?

What is the role of bone marrow aspiration and biopsy in the workup of Waldenström macroglobulinemia?

How are bone marrow biopsy findings characterized in Waldenström macroglobulinemia?

What is the role of genetic studies in the workup of Waldenström macroglobulinemia?

Treatment

What are the indications for treatment of Waldenström macroglobulinemia?

Which medications are used for the treatment of Waldenström macroglobulinemia?

What are the recommended medication protocols for the treatment of Waldenström macroglobulinemia?

What is the treatment approach for Waldenström macroglobulinemia?

What are the treatment recommendations from the International Workshops on Waldenström macroglobulinemia?

How is hyperviscosity syndrome treated in patients with Waldenström macroglobulinemia?

What is the front-line medication therapy for the treatment of Waldenström macroglobulinemia?

How effective is rituximab in the treatment of Waldenström macroglobulinemia?

How effective is ibrutinib (Imbruvica) in the treatment of Waldenström macroglobulinemia?

How effective are fludarabine and cladribine in the treatment of Waldenström macroglobulinemia?

What is the role of combination chemotherapy in the treatment of Waldenström macroglobulinemia?

Which medications are indicated in salvage therapy in the treatment of Waldenström macroglobulinemia?

How effective is thalidomide in salvage therapy for Waldenström macroglobulinemia?

How effective is bortezomib in salvage therapy for Waldenström macroglobulinemia?

How effective is everolimus in salvage therapy for Waldenström macroglobulinemia?

How effective is alemtuzumab in salvage therapy for Waldenström macroglobulinemia?

How is treatment response classified in Waldenström macroglobulinemia?

What are the treatment options for peripheral neuropathy in patients with Waldenström macroglobulinemia?

What are the IWWM8 recommendations for peripheral neuropathy treatment in Waldenström macroglobulinemia?

When is stem-cell transplantation indicated in the treatment of Waldenström macroglobulinemia?

How effective is stem cell transplantation in the treatment of Waldenström macroglobulinemia?

Guidelines

Which organizations have issued guidelines for the diagnosis and treatment of Waldenstrom macroglobulinemia (WM)?

What are the diagnostic guidelines for Waldenstrom macroglobulinemia (WM)?

What are the clinical guidelines for staging and risk assessment of Waldenstrom macroglobulinemia (WM)?

What are the treatment guidelines for Waldenstrom macroglobulinemia (WM)?

Medications

What is the medical therapy for Waldenström macroglobulinemia?

Which medications in the drug class Antineoplastics, mTOr Kinase Inhibitor are used in the treatment of Waldenstrom Macroglobulinemia?

Which medications in the drug class Antineoplastics, Proteasome Inhibitors are used in the treatment of Waldenstrom Macroglobulinemia?

Which medications in the drug class Immunomodulators are used in the treatment of Waldenstrom Macroglobulinemia?

Which medications in the drug class Antineoplastics, Monoclonal Antibody are used in the treatment of Waldenstrom Macroglobulinemia?

Which medications in the drug class Antineoplastics, Anthracycline are used in the treatment of Waldenstrom Macroglobulinemia?

Which medications in the drug class Antineoplastics, Antimetabolite are used in the treatment of Waldenstrom Macroglobulinemia?

Which medications in the drug class Antineoplastics, Alkylating are used in the treatment of Waldenstrom Macroglobulinemia?

Which medications in the drug class Antineoplastics, Tyrosine Kinase Inhibitor are used in the treatment of Waldenstrom Macroglobulinemia?

Which medications in the drug class Corticosteroids are used in the treatment of Waldenstrom Macroglobulinemia?