Solitary Plasmacytoma Differential Diagnoses

1. [Guideline] Rajkumar SV. Updated Diagnostic Criteria and Staging System for Multiple Myeloma. Am Soc Clin Oncol Educ Book. 2016. 35:e418-23. [QxMD MEDLINE Link]. [Full Text].

2. Thumallapally N, Meshref A, Mousa M, Terjanian T. Solitary plasmacytoma: population-based analysis of survival trends and effect of various treatment modalities in the USA. BMC Cancer. 2017 Jan 5. 17 (1):13. [QxMD MEDLINE Link]. [Full Text].

3. Wiltshaw E. The natural history of extramedullary plasmacytoma and its relation to solitary myeloma of bone and myelomatosis. Medicine (Baltimore). 1976 May. 55(3):217-38. [QxMD MEDLINE Link].

4. Frizzera G. Castleman's disease and related disorders. Semin Diagn Pathol. 1988 Nov. 5(4):346-64. [QxMD MEDLINE Link].

5. Hussong JW, Perkins SL, Schnitzer B, Hargreaves H, Frizzera G. Extramedullary plasmacytoma. A form of marginal zone cell lymphoma?. Am J Clin Pathol. 1999 Jan. 111(1):111-6. [QxMD MEDLINE Link].

6. Aalto Y, Nordling S, Kivioja AH, et al. Among numerous DNA copy number changes, losses of chromosome 13 are highly recurrent in plasmacytoma. Genes Chromosomes Cancer. 1999 Jun. 25(2):104-7. [QxMD MEDLINE Link].

7. Dimopoulos MA, Moulopoulos LA, Maniatis A, Alexanian R. Solitary plasmacytoma of bone and asymptomatic multiple myeloma. Blood. 2000 Sep 15. 96(6):2037-44. [QxMD MEDLINE Link]. [Full Text].

8. Low SF, Mohd Tap NH, Kew TY, Ngiu CS, Sridharan R. Non Secretory Multiple Myeloma With Extensive Extramedullary Plasmacytoma: A Diagnostic Dilemma. Iran J Radiol. 2015 Jul. 12 (3):e11760. [QxMD MEDLINE Link].

9. Zhang X, Su L, Ran YG, Qie S, Zhang X, Liu C, et al. Extramedullary plasmacytoma of the trachea: A case report and review of the literature. Medicine (Baltimore). 2018 Jan. 97 (3):e9594. [QxMD MEDLINE Link]. [Full Text].

10. Dimopoulos MA, Kiamouris C, Moulopoulos LA. Solitary plasmacytoma of bone and extramedullary plasmacytoma. Hematol Oncol Clin North Am. 1999 Dec. 13(6):1249-57. [QxMD MEDLINE Link].

11. Zhang D, Cao D, Shen D, Mulmi Shrestha S, Yin Y. Extramedullary plasmacytoma occuring in ileocecum: A case report and literature review. Medicine (Baltimore). 2017 Dec. 96 (51):e9313. [QxMD MEDLINE Link]. [Full Text].

12. Ellington TD, Henley SJ, Wilson RJ, Wu M, Richardson LC. Trends in solitary plasmacytoma, extramedullary plasmacytoma, and plasma cell myeloma incidence and myeloma mortality by racial-ethnic group, United States 2003-2016. Cancer Med. 2021 Jan. 10 (1):386-395. [QxMD MEDLINE Link]. [Full Text].

13. Galieni P, Cavo M, Pulsoni A, et al. Clinical outcome of extramedullary plasmacytoma. Haematologica. 2000 Jan. 85(1):47-51. [QxMD MEDLINE Link]. [Full Text].

14. Hu K, Yahalom J. Radiotherapy in the management of plasma cell tumors. Oncology (Williston Park). 2000 Jan. 14(1):101-8, 111; discussion 111-2, 115. [QxMD MEDLINE Link].

15. Alexiou C, Kau RJ, Dietzfelbinger H, et al. Extramedullary plasmacytoma: tumor occurrence and therapeutic concepts. Cancer. 1999 Jun 1. 85(11):2305-14. [QxMD MEDLINE Link]. [Full Text].

16. Liebross RH, Ha CS, Cox JD, et al. Clinical course of solitary extramedullary plasmacytoma. Radiother Oncol. 1999 Sep. 52(3):245-9. [QxMD MEDLINE Link].

17. Sharpley FA, Neffa P, Panitsas F, Kothari J, Subesinghe M, Cutter D, et al. Long-term clinical outcomes in a cohort of patients with solitary plasmacytoma treated in the modern era. PLoS One. 2019. 14 (7):e0219857. [QxMD MEDLINE Link]. [Full Text].

18. Kyle RA. Monoclonal gammopathy of undetermined significance and solitary plasmacytoma. Implications for progression to overt multiple myeloma. Hematol Oncol Clin North Am. 1997 Feb. 11(1):71-87. [QxMD MEDLINE Link].

19. Bataille R, Sany J. Solitary myeloma: clinical and prognostic features of a review of 114 cases. Cancer. 1981 Aug 1. 48(3):845-51. [QxMD MEDLINE Link].

20. Liebross RH, Ha CS, Cox JD, et al. Solitary bone plasmacytoma: outcome and prognostic factors following radiotherapy. Int J Radiat Oncol Biol Phys. 1998 Jul 15. 41(5):1063-7. [QxMD MEDLINE Link].

21. Holland J, Trenkner DA, Wasserman TH, Fineberg B. Plasmacytoma. Treatment results and conversion to myeloma. Cancer. 1992 Mar 15. 69(6):1513-7. [QxMD MEDLINE Link].

22. Wilder RB, Ha CS, Cox JD, et al. Persistence of myeloma protein for more than one year after radiotherapy is an adverse prognostic factor in solitary plasmacytoma of bone. Cancer. 2002 Mar 1. 94(5):1532-7. [QxMD MEDLINE Link]. [Full Text].

23. Mendenhall CM, Thar TL, Million RR. Solitary plasmacytoma of bone and soft tissue. Int J Radiat Oncol Biol Phys. 1980 Nov. 6(11):1497-501. [QxMD MEDLINE Link].

24. Susnerwala SS, Shanks JH, Banerjee SS, et al. Extramedullary plasmacytoma of the head and neck region: clinicopathological correlation in 25 cases. Br J Cancer. 1997. 75(6):921-7. [QxMD MEDLINE Link].

25. Krishnasamy G, Dhanasekar G. Extramedullary plasmacytoma of postnasal space. Kulak Burun Bogaz Ihtis Derg. 2013 May-Jun. 23(3):183-6. [QxMD MEDLINE Link].

26. Belic B, Mitrovic S, Arsenijevic S, Erdevicki L, Stojanovic J, Stojanovic S, et al. Nasal septum extramedullary plasmacytoma. Vojnosanit Pregl. 2013 Feb. 70(2):221-4. [QxMD MEDLINE Link].

27. Erdogan BA, Sekercan O, Dursun N, Tatar G, Bora F. Extramedullary plasmacytoma of maxillary sinus. J Craniofac Surg. 2013 Jan. 24(1):e85-7. [QxMD MEDLINE Link].

28. Burt M, Karpeh M, Ukoha O, et al. Medical tumors of the chest wall. Solitary plasmacytoma and Ewing's sarcoma. J Thorac Cardiovasc Surg. 1993 Jan. 105(1):89-96. [QxMD MEDLINE Link].

29. Read D, Warlow C. Peripheral neuropathy and solitary plasmacytoma. J Neurol Neurosurg Psychiatry. 1978 Feb. 41(2):177-84. [QxMD MEDLINE Link]. [Full Text].

30. Schindler OS, Briggs TW, Gillies SA. Bilateral demyelinating neuropathy in a solitary lytic and sclerotic myeloma of the proximal humerus: a case report. Int Orthop. 1997. 21(1):59-61. [QxMD MEDLINE Link].

31. Iwashita H, Ohnishi A, Asada M, Kanazawa Y, Kuroiwa Y. Polyneuropathy, skin hyperpigmentation, edema, and hypertrichosis in localized osteosclerotic myeloma. Neurology. 1977 Jul. 27(7):675-81. [QxMD MEDLINE Link].

32. Puliga G, Olla L, Bellisano G, Di Naro N, Ganau M, Lai ML, et al. Solitary extramedullary plasmacytoma of the thyroid gland associated with multinodular goiter: case report and review of the literature. Pathologica. 2011 Jun. 103(3):61-3. [QxMD MEDLINE Link].

33. [Guideline] National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Multiple Myeloma. NCCN. Available at https://www.nccn.org/professionals/physician_gls/pdf/myeloma.pdf. Version 4.2021 — December 10, 2020; Accessed: March 10, 2021.

34. Knowling MA, Harwood AR, Bergsagel DE. Comparison of extramedullary plasmacytomas with solitary and multiple plasma cell tumors of bone. J Clin Oncol. 1983 Apr. 1(4):255-62. [QxMD MEDLINE Link].

35. Brinch L, Hannisdal E, Abrahamsen AF, Kvaløy S, Langholm R. Extramedullary plasmacytomas and solitary plasma cell tumours of bone. Eur J Haematol. 1990 Feb. 44(2):132-5. [QxMD MEDLINE Link].

36. Bolek TW, Marcus RB, Mendenhall NP. Solitary plasmacytoma of bone and soft tissue. Int J Radiat Oncol Biol Phys. 1996 Sep 1. 36(2):329-33. [QxMD MEDLINE Link].

37. Jackson A, Scarffe JH. Prognostic significance of osteopenia and immunoparesis at presentation in patients with solitary myeloma of bone. Eur J Cancer. 1990 Mar. 26(3):363-71. [QxMD MEDLINE Link].

38. Galieni P, Cavo M, Avvisati G, et al. Solitary plasmacytoma of bone and extramedullary plasmacytoma: two different entities?. Ann Oncol. 1995 Sep. 6(7):687-91. [QxMD MEDLINE Link].

39. Frassica DA, Frassica FJ, Schray MF, Sim FH, Kyle RA. Solitary plasmacytoma of bone: Mayo Clinic experience. Int J Radiat Oncol Biol Phys. 1989 Jan. 16(1):43-8. [QxMD MEDLINE Link].

40. Grammatico S, Scalzulli E, Petrucci MT. Solitary Plasmacytoma. Mediterr J Hematol Infect Dis. 2017. 9 (1):e2017052. [QxMD MEDLINE Link]. [Full Text].

41. [Guideline] Caers J, Paiva B, Zamagni E, Leleu X, Bladé J, Kristinsson SY, et al. Diagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European Expert Panel. J Hematol Oncol. 2018 Jan 16. 11 (1):10. [QxMD MEDLINE Link]. [Full Text].

42. Fouquet G, Guidez S, Herbaux C, Van de Wyngaert Z, Bonnet S, Beauvais D, et al. Impact of initial FDG-PET/CT and serum-free light chain on transformation of conventionally defined solitary plasmacytoma to multiple myeloma. Clin Cancer Res. 2014 Jun 15. 20 (12):3254-60. [QxMD MEDLINE Link]. [Full Text].

43. Huvos AG, ed. Multiple myeloma including solitary osseous myeloma. Bone Tumors: Diagnosis, Treatment, and Prognosis. Philadelphia, Pa: WB Saunders Co; 1992. 653-67.

44. Miralles GD, O'Fallon JR, Talley NJ. Plasma-cell dyscrasia with polyneuropathy. The spectrum of POEMS syndrome. N Engl J Med. 1992 Dec 31. 327(27):1919-23. [QxMD MEDLINE Link].

45. Grammatico S, Scalzulli E, Petrucci MT. Solitary Plasmacytoma. Mediterr J Hematol Infect Dis. 2017. 9 (1):e2017052. [QxMD MEDLINE Link]. [Full Text].

46. Ooi GC, Chim JC, Au WY, Khong PL. Radiologic manifestations of primary solitary extramedullary and multiple solitary plasmacytomas. AJR Am J Roentgenol. 2006 Mar. 186(3):821-7. [QxMD MEDLINE Link]. [Full Text].

47. [Guideline] Soutar R, Lucraft H, Jackson G, et al. Guidelines on the diagnosis and management of solitary plasmacytoma of bone and solitary extramedullary plasmacytoma. Clin Oncol (R Coll Radiol). 2004 Sep. 16(6):405-13. [QxMD MEDLINE Link].

48. Mignot F, Schernberg A, Arsène-Henry A, Vignon M, Bouscary D, Kirova Y. Solitary plasmacytoma: Lenalidomide-Dexamethasone combined with radiation therapy improves progression-free survival and multiple myeloma-free survival. Int J Radiat Oncol Biol Phys. 2019 Nov 7. [QxMD MEDLINE Link].

49. Mignot F, Schernberg A, Arsène-Henry A, Vignon M, Bouscary D, Kirova Y. Solitary Plasmacytoma Treated by Lenalidomide-Dexamethasone in Combination with Radiation Therapy: Clinical Outcomes. Int J Radiat Oncol Biol Phys. 2020 Mar 1. 106 (3):589-596. [QxMD MEDLINE Link]. [Full Text].

Suzanne R Fanning, DO Director of Hematology, Greenville Memorial Health System; Medical Oncologist/Hematologist/Transplant Physician, Cancer Centers of the Carolinas

Suzanne R Fanning, DO is a member of the following medical societies: American College of Physicians, American Medical Association, American Society for Blood and Marrow Transplantation, American Society of Clinical Oncology, American Society of Hematology

Disclosure: Received consulting fee from Millenium Pharmaceuticals for review panel membership; Received consulting fee from Celgene Pharmaceuticals for review panel membership.

Mohamad A Hussein, MD Clinical Director, Malignant Hematology, Moffitt Cancer Center

Mohamad A Hussein, MD is a member of the following medical societies: American Association of Blood Banks, American College of Physicians, American Medical Association, American Society of Hematology

Disclosure: Received income in an amount equal to or greater than $250 from: Celgene corporation.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Emmanuel C Besa, MD Professor Emeritus, Department of Medicine, Division of Hematologic Malignancies and Hematopoietic Stem Cell Transplantation, Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University

Emmanuel C Besa, MD is a member of the following medical societies: American Association for Cancer Education, American Society of Clinical Oncology, American College of Clinical Pharmacology, American Federation for Medical Research, American Society of Hematology, New York Academy of Sciences

Disclosure: Nothing to disclose.

Paul Schick, MD † Emeritus Professor, Department of Internal Medicine, Jefferson Medical College of Thomas Jefferson University; Research Professor, Department of Internal Medicine, Drexel University College of Medicine; Adjunct Professor of Medicine, Lankenau Hospital

Paul Schick, MD is a member of the following medical societies: American College of Physicians, American Society of Hematology

Disclosure: Nothing to disclose.

Wendy Hu, MD Consulting Staff, Department of Hematology/Oncology and Bone Marrow Transplantation, Huntington Memorial Medical Center

Wendy Hu, MD is a member of the following medical societies: American Association for the Advancement of Science, American College of Physicians, American Society for Blood and Marrow Transplantation, American Society of Hematology, and Physicians for Social Responsibility

Disclosure: Nothing to disclose.

Fernando Perez-Zincer, MD Senior Fellow, Department of Hematology and Medical Oncology, The Cleveland Clinic Foundation Cancer Center

Disclosure: Nothing to disclose.

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