Immunoglobulin-Related Amyloidosis Questions & Answers

Updated: Nov 30, 2019
  • Author: Slavomir Urbancek, MD, PhD; Chief Editor: Emmanuel C Besa, MD  more...
  • Print
Questions & Answers

Overview

What is immunoglobulin-related amyloidosis?

What is the pathophysiology of immunoglobulin-related amyloidosis?

What causes immunoglobulin-related amyloidosis?

What is the US prevalence of immunoglobulin-related amyloidosis?

Which patient groups have the highest prevalence of immunoglobulin-related amyloidosis?

What is the global prevalence of immunoglobulin-related amyloidosis?

What is the prognosis of immunoglobulin-related amyloidosis?

Presentation

Which clinical history findings are characteristic of immunoglobulin-related amyloidosis?

Which physical findings are characteristic of immunoglobulin-related amyloidosis?

What causes orthostatic hypotension in patients with immunoglobulin-related amyloidosis?

What are the musculoskeletal findings characteristic of immunoglobulin-related amyloidosis?

Which arrhythmias may be caused by immunoglobulin-related amyloidosis?

What causes severe bleeding in patients with immunoglobulin-related amyloidosis?

What are the signs and symptoms of neuropathy in patients with immunoglobulin-related amyloidosis?

How does immunoglobulin-related amyloidosis affect the liver and spleen?

Which physical findings are characteristic of macroglossia in patients with immunoglobulin-related amyloidosis?

Which physical findings are characteristic of localized L chain-type amyloidosis?

DDX

What are the differential diagnoses for Immunoglobulin-Related Amyloidosis?

Workup

What is the role of lab tests in the workup of immunoglobulin-related amyloidosis?

What is the role of monoclonal immunoglobulin testing in the workup of immunoglobulin-related amyloidosis?

Which blood count findings are characteristic of immunoglobulin-related amyloidosis?

What is the role of coagulation studies in the workup of immunoglobulin-related amyloidosis?

Which urinalysis findings are characteristic of immunoglobulin-related amyloidosis?

Which liver function test results are characteristic of immunoglobulin-related amyloidosis?

Which renal function test results are characteristic of immunoglobulin-related amyloidosis?

Which bone marrow exam findings are characteristic of immunoglobulin-related amyloidosis?

What is the role of cardiac imaging in the workup of immunoglobulin-related amyloidosis?

What is the role of echocardiology in the workup of immunoglobulin-related amyloidosis?

What is the role of CMR in the workup of immunoglobulin-related amyloidosis?

What is the role of bone imaging in the workup of immunoglobulin-related amyloidosis?

What is the role of chest radiography in the workup of immunoglobulin-related amyloidosis?

What is the role of scintigraphy in the workup of immunoglobulin-related amyloidosis?

Which histologic findings are characteristic of immunoglobulin-related amyloidosis?

What is the role of electrocardiography in the workup of immunoglobulin-related amyloidosis?

What is the role of biopsy in the workup of immunoglobulin-related amyloidosis?

How is immunoglobulin-related amyloidosis diagnosed?

Treatment

What are the first-line treatments for immunoglobulin-related amyloidosis?

How is immunoglobulin-related amyloidosis treated?

What is the role of chemotherapy in the treatment of immunoglobulin-related amyloidosis?

What is the duration of chemotherapy in the treatment of immunoglobulin-related amyloidosis?

What is the history of treatment advances in the management of immunoglobulin-related amyloidosis?

What is the role of immunomodulatory drugs in the treatment of immunoglobulin-related amyloidosis?

What is the role of bone marrow or peripheral blood stem cell transplantation in the treatment of immunoglobulin-related amyloidosis?

What is the role of Idox in the treatment of immunoglobulin-related amyloidosis?

How is localized L chain-type amyloidosis treated?

What is included in supportive care for immunoglobulin-related amyloidosis?

What is the role of carpal tunnel surgery in the treatment of immunoglobulin-related amyloidosis?

What is the role of organ transplantation in the treatment of immunoglobulin-related amyloidosis?

Which specialist consultations are beneficial to patients with immunoglobulin-related amyloidosis?

What are the possible complications of immunoglobulin-related amyloidosis?

Guidelines

What are the mSMART treatment guidelines for immunoglobulin-related amyloidosis?

Medications

What is the role of medications in the treatment of immunoglobulin-related amyloidosis?

Which medications in the drug class Immunosuppressant Agents are used in the treatment of Immunoglobulin-Related Amyloidosis?

Which medications in the drug class Antineoplastic Agent, Proteasome Inhibitor are used in the treatment of Immunoglobulin-Related Amyloidosis?

Which medications in the drug class Immunosuppressive Agents are used in the treatment of Immunoglobulin-Related Amyloidosis?