17-Ketosteroids 

Updated: Feb 12, 2014
Author: Rajaa Almourani, MD; Chief Editor: Thomas M Wheeler, MD 

Reference Range

The reference range of urinary 17-ketosteroids is as follows[1] :

  • Males: 10-20 mg (34-69 ┬Ámol)/24 h

  • Females: 5-15 mg (17-52 ┬Ámol)/24 h

 

Interpretation

Increases in levels of 24-hour urinary 17-ketosteroids are associated with the following:

  • Adrenal tumors

  • Cushing syndrome

  • Ovarian cancer

  • Testicular cancer

  • Polycystic ovarian syndrome

  • Congenital adrenal hyperplasia (rare)

Decreases in levels of 24-hour urinary 17-ketosteroids are associated with the following:

  • Addison disease

  • Hypopituitarism

  • Myxedema

  • Nephrosis

  • Castration

 

Collection and Panels

Specifics for collection and panels are as follows:

  • Specimen type: Urine (see image below)

    Urine sample. Urine sample.
  • Collection method: 24-hour urine collection

  • Other instructions: Record duration and total volume

 

Background

Description

The 17-ketosteroids are breakdown products of androgens. Examples of 17-ketosteroids include androstenedione, androsterone, estrone, and dehydroepiandrosterone.

Indications/Applications

Newer tests have superseded 17-ketosteroid testing, and the assay is seldom used now.

Considerations

Drugs that can increase 17-ketosteroids measurements include the following:

  • Antibiotics (eg, penicillin, oxacillin)

  • Chlorpromazine

  • Ethinamate

  • Meprobamate

  • Phenaglycodol

  • Nalidixic acid

  • Spironolactone

Drugs that can decrease 17-ketosteroids measurements include the following:

  • Progestational agents

  • Carbamazepine

  • Cephalothin

  • Propoxyphene

  • Reserpine

  • Glucose

  • Chlordiazepoxide